Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Steven M. Mortin-Toth"'
Autor:
Tengfang Li, Khodor I. Abou-Daya, Sebastien Gingras, Hiromi Kubagawa, Peter Nickerson, Matthew L. Nicotra, Wenhao Chen, Jayne S. Danska, Peixiang Lan, Eiji Takayama, Chris Wiebe, Lisa R. Mathews, Steven M. Mortin-Toth, Jianjiao Chen, Heth R. Turnquist, Wentao Liu, Hehua Dai, Wei Chen, Daqiang Zhao, Amanda L. Williams, Andrew J. Friday, Tao Sun, Martin H. Oberbarnscheidt, Fadi G. Lakkis, Xian Chang Li, Mark J. Shlomchik
Publikováno v:
Frontiers in Immunology
Science
Science
Innate immune cells remember Immunological memory is a phenomenon by which immune cells can quickly recognize an antigen that the host has previously encountered. Certain cells of the innate immune system exhibit memory-like responses know as trained
Autor:
Alexandra Paun, Michelle C. Daigneault, Emma Allen-Vercoe, Leili Marandi, Shahab Meshkibaf, Steven M. Mortin-Toth, Philippe Poussier, Amit Bar-Or, Christopher Yau, Jayne S. Danska
Publikováno v:
Science immunology. 4(32)
Microbiome sequence analyses have suggested that changes in gut bacterial composition are associated with autoimmune disease in humans and animal models. However, little is known of the mechanisms through which the gut microbiota influences autoimmun
Autor:
Fadi G. Lakkis, Warren D. Shlomchik, Hehua Dai, Steven M. Mortin-Toth, David M. Rothstein, Martin H. Oberbarnscheidt, Matthew L. Nicotra, Khodor I. Abou-Daya, Jayne S. Danska, Amanda L. Williams, Jeffrey S. Isenberg, Takashi Matozaki, Andrew J. Friday
Publikováno v:
Science immunology. 2(12)
Mice devoid of T, B, and natural killer (NK) cells distinguish between self and allogeneic nonself despite the absence of an adaptive immune system. When challenged with an allograft, they mount an innate response characterized by accumulation of mat
Autor:
Shinya Ito, Katarina Aleksa, Casey J. Fox, Evgueni A. Ivakine, Andrew D. Paterson, Steven M. Mortin-Toth, David S. Walton, Jayne S. Danska, Angelo J. Canty
Publikováno v:
The Journal of Immunology. 174:7129-7140
Many human autoimmune diseases are more frequent in females than males, and their clinical severity is affected by sex hormone levels. A strong female bias is also observed in the NOD mouse model of type I diabetes (T1D). In both NOD mice and humans,
Autor:
Omid M. Gulban, Charles A. Steward, Vinicius Motta, Jeremy Mogridge, Steven M. Mortin-Toth, Kuo Chien Liao, Jayne S. Danska, Janet Markle
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 194(12)
Type 1 diabetes in the NOD mouse model has been linked to >30 insulin-dependent diabetes (Idd) susceptibility loci. Idd4 on chromosome 11 consists of two subloci, Idd4.1 and Idd4.2. Using congenic analysis of alleles in NOD and NOD-resistant (NOR) mi
Autor:
Steven M. Mortin-Toth, Giancarlo Russo, Mario Nuvolone, Daiji Sakata, Gregor Hutter, Jayne S. Danska, Adriano Aguzzi, Veronika Kana
Publikováno v:
The Journal of Experimental Medicine
JOURNAL OF EXPERIMENTAL MEDICINE
Journal of Experimental Medicine
The Journal of experimental medicine
JOURNAL OF EXPERIMENTAL MEDICINE
Journal of Experimental Medicine
The Journal of experimental medicine
The regulation of phagocytosis previously ascribed to prion protein PrPC is found to be controlled by the linked locus encoding SIRPα.
Prnp−/− mice lack the prion protein PrPC and are resistant to prion infections, but variable phenotypes h
Prnp−/− mice lack the prion protein PrPC and are resistant to prion infections, but variable phenotypes h
Publikováno v:
The American Journal of Human Genetics. 67(1):67-81
Insulin-dependent diabetes mellitus (IDDM) is a polygenic disease caused by progressive autoimmune infiltration (insulitis) of the pancreatic islets of Langerhan, culminating in the destruction of insulin-producing beta cells. Genome scans of familie
Autor:
Charles E. Robertson, Steven M. Mortin-Toth, Daniel N. Frank, Jayne S. Danska, Andrew J. Macpherson, Leah M. Feazel, Kathy D. McCoy, Martin von Bergen, Ulrike Rolle-Kampczyk, Janet Markle
Publikováno v:
Markle, J G M, Frank, D N, Mortin-Toth, S, Robertson, C E, Feazel, L M, Rolle-Kampczyk, U, von Bergen, M, McCoy, K D, Macpherson, A J & Danska, J S 2013, ' Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity ', Science, vol. 339, no. 6123, pp. 1084-1088 . https://doi.org/10.1126/science.1233521
Science (New York N.Y.)
Science (New York N.Y.)
Mighty Male Microbes Both genetic and environmental factors contribute to an individual's susceptibility to autoimmune disease, but the specific environmental influences are not well characterized. Markle et al. (p. 1084 , published online 17 January
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::455a5b10e562ed42e48fdcc125e8679e
https://vbn.aau.dk/da/publications/7bf0b8b4-0f48-42d4-a7b5-4516cfe2703f
https://vbn.aau.dk/da/publications/7bf0b8b4-0f48-42d4-a7b5-4516cfe2703f
Autor:
John E. Dick, Sam Khalouei, Katsuto Takenaka, Jean C.Y. Wang, Steven M. Mortin-Toth, Jayne S. Danska, Tatiana K. Prasolava, Olga I. Gan
Publikováno v:
Nature immunology. 8(12)
Graft failure in the transplantation of hematopoietic stem cells occurs despite donor-host genetic identity of human leukocyte antigens, suggesting that additional factors modulate engraftment. With the nobese diabetic (NOD)-severe combined immunodef
Autor:
Omid M. Gulban, Jayne S. Danska, Evgueni A. Ivakine, Aneta Valova, Angelo J. Canty, Steven M. Mortin-Toth, C.A. Scott
Publikováno v:
Diabetes. 55(12)
The nonobese diabetic (NOD) mouse recapitulates many aspects of the pathogenesis of type 1 diabetes in humans, including inheritance as a complex trait. More than 20 Idd loci have been linked to type 1 diabetes susceptibility in NOD mice. Previously,