Genomic heterogeneity underlies multidrug resistance in Pseudomonas aeruginosa: A population-level analysis beyond susceptibility testing.

Autor: Laura J Rojas, Mohamad Yasmin, Jacquelynn Benjamino, Steven M Marshall, Kailynn J DeRonde, Nikhil P Krishnan, Federico Perez, Andrew A Colin, Monica Cardenas, Octavio Martinez, Armando Pérez-Cardona, Daniel D Rhoads, Michael R Jacobs, John J LiPuma, Michael W Konstan, Alejandro J Vila, Andrea Smania, Andrew R Mack, Jacob G Scott, Mark D Adams, Lilian M Abbo, Robert A Bonomo

Publikováno v: PLoS ONE, Vol 17, Iss 3, p e0265129 (2022)

BackgroundPseudomonas aeruginosa is a persistent and difficult-to-treat pathogen in many patients, especially those with Cystic Fibrosis (CF). Herein, we describe a longitudinal analysis of a series of multidrug resistant (MDR) P. aeruginosa isolates

Externí odkaz: https://doaj.org/article/b792cfbcd3cf4cadae6ebcb48376470a

Emergence of Resistance to Ceftazidime-Avibactam in a Pseudomonas aeruginosa Isolate Producing Derepressed bla PDC in a Hollow-Fiber Infection Model

Autor: Laura J. Rojas, Mark Raymond Adams, Jürgen B. Bulitta, Michael Vicchiarelli, Maria F. Mojica, Liang Chen, Barry N. Kreiswirth, Robert A. Bonomo, Steven M Marshall, Meredith Bacci, Nino Mtchedlidze, George L. Drusano, Arnold Louie

Publikováno v: Antimicrobial Agents and Chemotherapy. 65

Ceftazidime (CAZ)-avibactam (AVI) is a β-lactam/β-lactamase inhibitor combination with activity against type A and type C β-lactamases. Resistance emergence has been seen, with multiple mechanisms accounting for the resistance. We performed four e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46bf038a0e18b6c137933e1263e403a2
https://doi.org/10.1128/aac.00124-21

Genomic heterogeneity underlies multidrug resistance in Pseudomonas aeruginosa: A population-level analysis beyond susceptibility testing.

Autor: Rojas, Laura J.^1,2,3 (AUTHOR), Yasmin, Mohamad² (AUTHOR), Benjamino, Jacquelynn⁴ (AUTHOR), Marshall, Steven M.² (AUTHOR), DeRonde, Kailynn J.⁵ (AUTHOR), Krishnan, Nikhil P.^6,7 (AUTHOR), Perez, Federico^8,9,10,11 (AUTHOR), Colin, Andrew A.¹² (AUTHOR), Cardenas, Monica¹² (AUTHOR), Martinez, Octavio^5,13 (AUTHOR), Pérez-Cardona, Armando⁵ (AUTHOR), Rhoads, Daniel D.^14,15 (AUTHOR), Jacobs, Michael R.¹⁵ (AUTHOR), LiPuma, John J.¹⁶ (AUTHOR), Konstan, Michael W.¹⁷ (AUTHOR), Vila, Alejandro J.¹⁸ (AUTHOR), Smania, Andrea^9,19 (AUTHOR), Mack, Andrew R.^1,2 (AUTHOR), Scott, Jacob G.^6,7 (AUTHOR), Adams, Mark D.⁴ (AUTHOR)

Publikováno v: PLoS ONE. 3/31/2022, Vol. 17 Issue 3, p1-16. 16p.

Activity of ceftazidime/avibactam against isogenic strains of Escherichia coli containing KPC and SHV β-lactamases with single amino acid substitutions in the Ω-loop.

Autor: Winkler, Marisa L., Papp-Wallace, Krisztina M., Bonomo, Robert A.

Publikováno v: Journal of Antimicrobial Chemotherapy (JAC); Aug2015, Vol. 70 Issue 8, p2279-2286, 8p

Effect of intracarotid papaverine on human cerebral blood flow and vascular resistance during acute hemispheric arterial hypotension.

Autor: Joshi, Shailendra, Hashimoto, Tomoki, Ostapkovich, Noeleen, Pile-Spellman, John, Duong, D. Hoang, Hacien-Bey, Lofti, Marshall, Randolph S., James, David J., Young, William L., Joshi, S, Hashimoto, T, Ostapkovich, N, Pile-Spellman, J, Duong, D H, Hacein-Bey, L, Hacien-Bey, L, Marshall, R S, James, D J, Young, W L

Publikováno v: Journal of Neurosurgical Anesthesiology; Apr2001, Vol. 13 Issue 2, p146-151, 6p