Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Steven M. Leonardo"'
Autor:
Anissa S H Chan, Adria Bykowski Jonas, Xiaohong Qiu, Nadine R Ottoson, Richard M Walsh, Keith B Gorden, Ben Harrison, Peter J Maimonis, Steven M Leonardo, Kathleen E Ertelt, Michael E Danielson, Kyle S Michel, Mariana Nelson, Jeremy R Graff, Myra L Patchen, Nandita Bose
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0165909 (2016)
Imprime PGG (Imprime), an intravenously-administered, soluble β-glucan, has shown compelling efficacy in multiple phase 2 clinical trials with tumor targeting or anti-angiogenic antibodies. Mechanistically, Imprime acts as pathogen-associated molecu
Externí odkaz:
https://doaj.org/article/357100ff914f42d797e55b32fe9e7a5d
Autor:
Steven M. Leonardo, Ross B. Fulton, Kathryn A. Fraser, Mark T. Uhlik, Xiaohong Qiu, Jamie Lowe, Mark A. Matson, Keith B. Gorden, Lindsay R Jordan, Nadine R. Ottoson, Nandita Bose, Blaine Rathmann, Adria Jonas, Richard Walsh, Takashi O Kangas, Ben Harrison, Anissa S.H. Chan, Kathleen E. Ertelt, Jeremy R. Graff, Richard D. Huhn
Publikováno v:
The Journal of Immunology. 202:2945-2956
Imprime PGG (Imprime) is an i.v. administered, yeast β-1,3/1,6 glucan in clinical development with checkpoint inhibitors. Imprime-mediated innate immune activation requires immune complex formation with naturally occurring IgG anti-β glucan Abs (AB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3956a5f20a4932ae6bfbd8c850bad69e
https://doi.org/10.4049/jimmunol.1801533
https://doi.org/10.4049/jimmunol.1801533
Autor:
Steven M. Leonardo, Weston Maier, Stephen B. Gauld, Jessica L. De Santis, Jennifer A. McGraw, Joseph M. Kulinski, Elizabeth A. Ruder, Vera L. Tarakanova
Publikováno v:
Immunology. 139:197-204
Viruses such as Epstein–Barr virus (EBV) have been linked to mechanisms that support autoantibody production in diseases such as systemic lupus erythematosus. However, the mechanisms by which viruses contribute to autoantibody production remain poo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::990afffed16f041d9e2cede5d5a2049d
https://doi.org/10.1111/imm.12069
https://doi.org/10.1111/imm.12069
Autor:
Ben J. Harrison, Nandita Bose, Xiaohong Qiu, Kyle S. Michel, Jeremy R. Graff, Richard Walsh, Mariana I. Nelson, Nadine R. Ottoson, Adria Jonas, Keith B. Gorden, Steven M. Leonardo, Michael E. Danielson, Kathleen E. Ertelt, Peter Maimonis, Anissa S.H. Chan, Myra L. Patchen
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 11, p e0165909 (2016)
PLoS ONE, Vol 11, Iss 11, p e0165909 (2016)
Imprime PGG (Imprime), an intravenously-administered, soluble β-glucan, has shown compelling efficacy in multiple phase 2 clinical trials with tumor targeting or anti-angiogenic antibodies. Mechanistically, Imprime acts as pathogen-associated molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f58209753cfca1dd1d9d1f444649633e
http://europepmc.org/articles/PMC5094785
http://europepmc.org/articles/PMC5094785
Autor:
Stephen B. Gauld, Laurent Malherbe, Ashley L. Gehrand, Jessica L. De Santis, Steven M. Leonardo
Publikováno v:
European Journal of Immunology. 42:2597-2607
The maintenance of B-cell anergy is essential to prevent the production of autoantibodies and autoimmunity. However, B-cell extrinsic mechanisms that regulate B-cell anergy remain poorly understood. We previously demonstrated that regulatory T (Treg)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::291a8a576da2b5e80a202a4b87d3395d
https://doi.org/10.1002/eji.201242616
https://doi.org/10.1002/eji.201242616
Publikováno v:
The Journal of Immunology. 188:5223-5226
The absence of regulatory T cells (Tregs) results in significant immune dysregulation that includes autoimmunity. The mechanism(s) by which Tregs suppress autoimmunity remains unclear. We have shown that B cell anergy, a major mechanism of B cell tol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c0d499b50dc4c2debf9ad96e914f52a
https://doi.org/10.4049/jimmunol.1103731
https://doi.org/10.4049/jimmunol.1103731
Publikováno v:
Virology. 405(1):50-61
Many herpesvirus-encoded protein kinases facilitate viral lytic replication. Importantly, the role of viral kinases in herpesvirus latency is less clear. Mouse gammaherpesvirus-68 (MHV68)-encoded protein kinase orf36 facilitates lytic replication in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32db1d14e92ae6d978ef326d4f5a721f
Autor:
Ben J. Harrison, Keith B. Gorden, Jamie Lowe, Steven M. Leonardo, Richard Walsh, Mark Uhlik, Michael Chisamore, Kathleen E. Ertelt, Nandita Bose, Michele Gargano, Jeremy R. Graff, Bruno Osterwalder
Publikováno v:
Cancer Research. 78:LB-129
Imprime PGG is a novel, IV administered 1,3/1,6 β-glucan PAMP (pathogen-associated molecular pattern) that activates innate immune effector cells to enhance tumor killing, to repolarize the suppressive myeloid cells of the tumor microenvironment and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c06ba9f545602f2ddeae6033e994a69a
https://doi.org/10.1158/1538-7445.am2018-lb-129
https://doi.org/10.1158/1538-7445.am2018-lb-129
Autor:
Jeremy R. Graff, Takashi Kangas, Ross B. Fulton, Yumi Yokoyama, Ben J. Harrison, Mark Uhlik, Keith B. Gorden, Steven M. Leonardo, Kathryn A. Fraser, Nandita Bose
Publikováno v:
Cancer Research. 78:3767-3767
Cancer therapy has been reshaped by checkpoint inhibitors (CPIs), making it possible for durable responses against cancers with traditionally low cure rates. Current efforts are focused on combination therapies in the hopes of evading resistance to C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2c44efba809dcabcb348f1d5954bb19
https://doi.org/10.1158/1538-7445.am2018-3767
https://doi.org/10.1158/1538-7445.am2018-3767
Autor:
Richard D. Huhn, Mable Ma, Michael Chisamore, Richard Walsh, Steven J. O'Day, Nandita Bose, Jeremy R. Graff, Steven M. Leonardo, Bruno Osterwalder, Michele Gargano, Paulette Mattson, Mark Uhlik, Radha Prathikanti, Ben J. Harrison, Jamie Lowe, Katie Ertelt, Xiaohong Qiu, Nadine Ottoson
Publikováno v:
Molecular Cancer Therapeutics. 17:LB-A31
Imprime PGG (Imprime) is a novel immunotherapeutic that acts as a non-self danger signal to activate the innate immune system and coordinate an adaptive immune system response. In multiple preclinical tumor models, Imprime significantly enhances anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e1ddeb837044cf114997937b4d6541d
https://doi.org/10.1158/1535-7163.targ-17-lb-a31
https://doi.org/10.1158/1535-7163.targ-17-lb-a31