Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Steven M. Hersch"'
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
There is increasing evidence that impairments of cerebrovascular function and/or abnormalities of the cerebral vasculature might contribute to early neuronal cell loss in Huntington’s disease (HD). Studies in both healthy individuals as well as in
Externí odkaz:
https://doaj.org/article/c2fc3529ddc748318e5285b288eaca15
Autor:
Fran Norflus, Agnes Nanje, Claire-Anne Gutekunst, Geming Shi, Joshua Cohen, Michelle Bejarano, Jonathan Fox, Robert J. Ferrante, Steven M. Hersch
Publikováno v:
Neurobiology of Disease, Vol 17, Iss 2, Pp 319-325 (2004)
Inflammatory mechanisms have been implicated in the pathogenesis of Huntington's disease (HD). Possible benefits of anti-inflammatory treatments include improved folding of mutant huntingtin mediated through chaperones, reduction of destructive cellu
Externí odkaz:
https://doaj.org/article/89449822cd2a4f9a9a5092927ddfe344
Autor:
Ole A. Andreassen, Alpaslan Dedeoglu, Robert J. Ferrante, Bruce G. Jenkins, Kimberly L. Ferrante, Melissa Thomas, Avi Friedlich, Susan E. Browne, Gabriele Schilling, David R. Borchelt, Steven M. Hersch, Christopher A. Ross, M.Flint Beal
Publikováno v:
Neurobiology of Disease, Vol 8, Iss 3, Pp 479-491 (2001)
There is substantial evidence for bioenergetic defects in Huntington's disease (HD). Creatine administration increases brain phosphocreatine levels and it stabilizes the mitochondrial permeability transition. We examined the effects of creatine admin
Externí odkaz:
https://doaj.org/article/c7919301b51e4f6c8b3393673832e9df
Autor:
Hilda T. Maibach, Michael J. Brownstein, Steven M. Hersch, Karen E. Anderson, Debra E. Itzkowitz, Eve M. Damiano, Neal G. Simon
Publikováno v:
Journal of Personalized Medicine; Volume 12; Issue 10; Pages: 1561
SRX246, an orally available CNS penetrant vasopressin (VP) V1a receptor antagonist, was studied in Huntington’s disease (HD) patients with irritability and aggressive behavior in the exploratory phase 2 trial, Safety, Tolerability, and Activity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1c2cef8eb6c1531b01b5e92bbddbf6c
Publikováno v:
Neurology
article-version (Version of Record) 3
article-version (Version of Record) 3
ObjectiveTo quantify the percent volume of dilated perivascular spaces (PVS) in the subcortical forebrain in patients with early Huntington's disease (HD) and to explore the relationship between PVS and disease severity.MethodsMRI scans were performe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78705281c4cfa1cb0c00887e8864d1e1
http://europepmc.org/articles/PMC8105900
http://europepmc.org/articles/PMC8105900
Autor:
Andrew McGarry, Peggy Auinger, Karl D. Kieburtz, Amy-Lee Bredlau, Steven M. Hersch, H. Diana Rosas
Publikováno v:
Neurol Clin Pract
Background and ObjectivesSuicidality is a common concern in the routine care of persons with Huntington disease (HD) and for the many participants in HD clinical trials. In a previous analysis, we identified baseline and time-dependent factors associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f165dc665255adfe4d95858e8c0d855f
https://europepmc.org/articles/PMC9208406/
https://europepmc.org/articles/PMC9208406/
Autor:
Steven M. Hersch, Douglas R. Langbehn
Publikováno v:
Movement Disorders
Background Huntington's disease (HD) develops in individuals with extended cytosine-adenine-guanine (CAG) repeats within the huntingtin (HTT) gene, causing neurodegeneration and progressive motor and cognitive symptoms. The inclusion of mutant HTT ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c257b4d9186c3f1653863c6491ab20e
https://doi.org/10.1002/mds.28222
https://doi.org/10.1002/mds.28222
Autor:
Melanie Benge, Amie L. Hiller, Carolyn Gray, Michele Costigan, H. Diana Rosas, Stephanie Lowenhaupt, Rosalind S Chuang, Peter Hedera, Danny Bega, Matthew J. Barrett, Marianne Chase, Jon W. Yankey, Jessica Lamb, Elaine Sperin, Susan Perlman, Christina Gruenwald, Joseph F. Quinn, Joyce Ann Moran, Lauren Seeberger, Debra E Itzkowitz, Brenton A Wright, Kelly Lowen, Karen E. Anderson, Victor W. Sung, Angela Molloy, Frederick J. Marshall, Patricia Conlon, Hilda T Maibach, Jamie L Adams, Elaine Most, Stewart A. Factor, Karen Marder, Allison M. Daley, Shifang Lu, Carlos Singer, Michael J Brownstein, Neal G. Simon, Amy M Chesire, Valerie Suski, Codrin Lungu, Kellie Keith, Christopher S. Coffey, Guy J Schwartz, Zsazsa R Brown, Richard Dubinsky, Catherine Gladden, Paola Wall, Jeremy M. Shefner, Steven M. Hersch, Cara Jacob, Jeffrey D. Long, Dixie Ecklund, Padraig E. O'Suilleabhain, Andrew P. Duker, J. Singleton, Meghan Zorn, Carolyn Drazinic, Mark Quigg, Eve M Damiano, Sandra K. Kostyk, Brenda Thornell, Andrew McGarry, Merit Cudkowicz, Robin Conwit, Paul Deritis, Joel S. Perlmutter
Publikováno v:
Journal of Clinical Medicine
Volume 9
Issue 11
Journal of Clinical Medicine, Vol 9, Iss 3682, p 3682 (2020)
Volume 9
Issue 11
Journal of Clinical Medicine, Vol 9, Iss 3682, p 3682 (2020)
SRX246 is a vasopressin (AVP) 1a receptor antagonist that crosses the blood-brain barrier. It reduced impulsive aggression, fear, depression and anxiety in animal models, blocked the actions of intranasal AVP on aggression/fear circuits in an experim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a6ab53df7b21fa094318e696048bfcc
Autor:
Steven M. Hersch, Anastasia Yendiki, Mark Vangel, H. D. Rosas, Paul Wilkens, Nathaniel D. Mercaldo, David H. Salat
Publikováno v:
NeuroImage : Clinical
NeuroImage: Clinical, Vol 20, Iss, Pp 236-242 (2018)
NeuroImage: Clinical, Vol 20, Iss, Pp 236-242 (2018)
Although much prior work has focused on the basal ganglia and cortical pathology that defines Huntington's disease (HD), recent studies have also begun to characterize cerebral white matter damage (Rosas et al., 2006; Dumas et al., 2012; Poudel et al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d30982047900d7aa604aeca61939c180
https://doi.org/10.1016/j.nicl.2018.01.029
https://doi.org/10.1016/j.nicl.2018.01.029
Autor:
Karen Marder, Steven M. Hersch, David Oakes, Anne B. Young, Ira Shoulson, Elise Kayson, Karen E. Anderson, Shirley Eberly, Kevin Biglan
Publikováno v:
Journal of Huntington's disease. 8(4)
BACKGROUND There is limited understanding of the feasibility of conducting long-term research among undiagnosed (pre-symptomatic) adults at risk to develop Huntington disease (HD), while protecting their emotional well-being and safety. OBJECTIVE To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b46cd4668d9ef236efa6dca6554270e
https://pubmed.ncbi.nlm.nih.gov/31381523
https://pubmed.ncbi.nlm.nih.gov/31381523