Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Steven M. Heaton"'
Autor:
Sundy N. Y. Yang, Sarah C. Atkinson, Michelle D. Audsley, Steven M. Heaton, David A. Jans, Natalie A. Borg
Publikováno v:
Cells, Vol 9, Iss 1, p 170 (2020)
Viral disease is one of the greatest burdens for human health worldwide, with an urgent need for efficacious antiviral strategies. While antiviral drugs are available, in many cases, they are prone to the development of drug resistance. A way to over
Externí odkaz:
https://doaj.org/article/4f0b210aaf3d40578aff1ed5a75063b4
Autor:
Steven M. Heaton, Sarah C. Atkinson, Melissa N. Sweeney, Sundy N. Y. Yang, David A. Jans, Natalie A. Borg
Publikováno v:
Cells, Vol 8, Iss 10, p 1181 (2019)
DEAD-box helicase 3, X-linked (DDX3X) regulates the retinoic acid-inducible gene I (RIG-I)-like receptor (RLR)-mediated antiviral response, but can also be a host factor contributing to the replication of viruses of significance to human health, such
Externí odkaz:
https://doaj.org/article/3ad28a06abdf4916a62a2e524aadf905
Publikováno v:
PLoS Pathogens, Vol 17, Iss 12, p e1010091 (2021)
There are strong incentives for human populations to develop antiviral systems. Similarly, genomes that encode antiviral systems have had strong selective advantages. Protein-guided immune systems, which have been well studied in mammals, are necessa
Externí odkaz:
https://doaj.org/article/250d078d6d7e423fa209b63dfc907966
Autor:
Steven M Heaton
Publikováno v:
Clinical & Translational Immunology, Vol 9, Iss 2, Pp n/a-n/a (2020)
Externí odkaz:
https://doaj.org/article/8ee12e537d1b4e0986fc0881520e7498
Publikováno v:
Trends in microbiology.
Antiretroviral therapy (ART) reduces human immunodeficiency virus type 1 (HIV-1) infection, but selection of treatment-refractory variants remains a major challenge. HIV-1 encodes 16 canonical proteins, a small number of which are the singular target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d41d4c7ad7e76c060e2b90c37c0fcc4
https://pubmed.ncbi.nlm.nih.gov/36463019
https://pubmed.ncbi.nlm.nih.gov/36463019
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 16
International Journal of Molecular Sciences, Vol 22, Iss 9094, p 9094 (2021)
Volume 22
Issue 16
International Journal of Molecular Sciences, Vol 22, Iss 9094, p 9094 (2021)
The cytoplasmic retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs) initiate interferon (IFN) production and antiviral gene expression in response to RNA virus infection. Consequently, RLR signalling is tightly regulated by both host and vir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5c22b1790b77f9f10d605fa8508cae7
Autor:
Natalie A. Borg, David A. Jans, Steven M. Heaton, Sundy N.Y. Yang, Sarah C. Atkinson, Melissa N. Sweeney
Publikováno v:
Cells, Vol 8, Iss 10, p 1181 (2019)
Cells
Volume 8
Issue 10
Cells
Volume 8
Issue 10
DEAD-box helicase 3, X-linked (DDX3X) regulates the retinoic acid-inducible gene I (RIG-I)-like receptor (RLR)-mediated antiviral response, but can also be a host factor contributing to the replication of viruses of significance to human health, such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9af19e7910718b05604b13e15cd67776
https://www.mdpi.com/2073-4409/8/10/1181
https://www.mdpi.com/2073-4409/8/10/1181
Autor:
Niluka D. Wasalathanthri, Syed Shan-e-Ali Zaidi, Elena Mahrt, Sudhakar Srivastava, Kun-Hsing Yu, Karin S. L. Johansson, Fengbo Li, Maria Fernanda Torres Jimenez, Cody Lo, Veerasathpurush Allareddy, Carmen Romero-Molina, Signe Mosegaard, Steven M. Heaton, Jonathan Joon-Young Park, Christine D. Bacon, Sha Yu, Emre Ozan Polat, Dhanuka Wasalathanthri, Wei Wang, Divyansh Agarwal
Publikováno v:
Wasalathanthri, N D, Zaidi, S S E A, Mahrt, E, Srivastava, S, Yu, K H, Johansson, K S L, Li, F, Jimenez, M F T, Lo, C, Allareddy, V, Romero-Molina, C, Mosegaard, S, Heaton, S M, Park, J J Y, Bacon, C D, Yu, S, Polat, E O, Wasalathanthri, D, Wang, W & Agarwal, D 2019, ' Challenging transitions ', Science, vol. 363, no. 6422, pp. 24-26 . https://doi.org/10.1126/science.aaw2641
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ac003ba05a661edec602e92dc0751bd
https://pure.au.dk/portal/da/publications/challenging-transitions(e82cdfca-c8f0-444e-aa4b-c1c86f3c25c5).html
https://pure.au.dk/portal/da/publications/challenging-transitions(e82cdfca-c8f0-444e-aa4b-c1c86f3c25c5).html
Autor:
Steven M. Heaton
Publikováno v:
Drugs of the Future. 46:207
A therapeutic gap exists between new emerging infectious diseases and effective treatments. Targeting host factors involved in the replication strategies of evolutionarily diverse viruses may bridge this gap. Exportin-1 (XPO1, also termed chromosome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::502d33de3fce635a76348a7d8452ac0a
https://doi.org/10.1358/dof.2021.46.3.3220729
https://doi.org/10.1358/dof.2021.46.3.3220729
Publikováno v:
Journal of Virology
The nucleolar subcompartment of the nucleus is increasingly recognized as an important target of RNA viruses. Here we document for the first time the ability of dengue virus (DENV) polymerase, nonstructural protein 5 (NS5), to accumulate within the n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::319fa0925e1f58921c1482b72bf22eb6
https://doi.org/10.1128/jvi.02727-15
https://doi.org/10.1128/jvi.02727-15