Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Steven M. Crespo-Carbone"'
Autor:
Ellen Z. Baum, Barbara D. Foleno, Todd A. Davies, Steven M. Crespo-Carbone, Anne Marie Queenan, Karen Bush, Wenping He, Brian J. Morrow
Publikováno v:
Antimicrobial Agents and Chemotherapy. 53:2785-2790
Ceftobiprole, an anti-methicillin-resistant Staphylococcus aureus broad-spectrum cephalosporin, has activity (MIC for 50% of strains tested, ≤4 μg/ml) against many Pseudomonas aeruginosa strains. A common mechanism of P . aeruginosa resistance to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e178dac37e47b000cd8b5a7b43f996a
https://doi.org/10.1128/aac.00018-09
https://doi.org/10.1128/aac.00018-09
Autor:
Ellen Z. Baum, Karen Bush, Barbara D. Foleno, Alexandra L. Klinger, Steven M. Crespo-Carbone, Ignatius J. Turchi, Mark J. Macielag
Publikováno v:
Antimicrobial Agents and Chemotherapy. 51:4420-4426
MurF is an essential enzyme of bacterial cell wall biosynthesis. Few MurF inhibitors have been reported, and none have displayed measurable antibacterial activity. Through the use of a MurF binding assay, a series of 8-hydroxyquinolines that bound to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95f185544ccda53f72e771b610872afa
https://doi.org/10.1128/aac.00845-07
https://doi.org/10.1128/aac.00845-07
Autor:
Barbara D. Foleno, Steven M. Crespo-Carbone, Darren Abbanat, Amy Maden, Raul Goldschmidt, Karen Bush, Ellen Z. Baum
Publikováno v:
Antimicrobial Agents and Chemotherapy. 50:230-236
MurF is a key enzyme in the biosynthesis of the bacterial cell wall in both gram-positive and gram-negative bacteria. This enzyme has not been extensively exploited as a drug target, possibly due to the difficulty in obtaining one of the substrates,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa4b3637b1f5285771d4fec0dcbf98c5
https://doi.org/10.1128/aac.50.1.230-236.2006
https://doi.org/10.1128/aac.50.1.230-236.2006
Autor:
Yarí E. Marín, Christiane M. Robbins, Daniel Sinsimer, Suzie Chen, Jeffrey J. Martino, Izabela Makalowska, Raman Sood, Jeffrey M. Trent, Karine A. Cohen-Solal, Steven M. Crespo-Carbone
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1651:68-75
Rab proteins, a subfamily of the ras superfamily, are low molecular weight GTPases involved in the regulation of intracellular vesicular transport. Cloning of human RAB32 was recently described. Presently, we report the cloning and characterization o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b33be595a3ec8fd68a984f8a5b32e834
https://doi.org/10.1016/s1570-9639(03)00236-x
https://doi.org/10.1016/s1570-9639(03)00236-x
Autor:
Brian J. Morrow, A. Simon Lynch, Darren Abbanat, Wenping He, Ellen Z. Baum, Todd A. Davies, Wenchi Shang, Anne Marie Queenan, Steven M. Crespo-Carbone
Publikováno v:
Antimicrobial agents and chemotherapy. 55(12)
The new broad-spectrum fluoroquinolone JNJ-Q2 displays in vitro activity against Gram-negative and Gram-positive organisms, including methicillin-resistant Staphylococcus aureus (MRSA) and ciprofloxacin-resistant MRSA isolates. Tested with isogenic m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e6d6555ed1de0896059d228742f4d73
https://pubmed.ncbi.nlm.nih.gov/21911562
https://pubmed.ncbi.nlm.nih.gov/21911562
Autor:
Jerome Guillemont, Lee D. Simon, Karen Bush, Ellen Z. Baum, Mark J. Macielag, Steven M. Crespo-Carbone, Barbara D. Foleno
MurF catalyzes the last cytoplasmic step of bacterial cell wall synthesis and is essential for bacterial survival. Our previous studies used a pharmacophore model of a MurF inhibitor to identify additional inhibitors with improved properties. We now
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8a5f3b97f678e999e97074e59457a31
https://europepmc.org/articles/PMC2715636/
https://europepmc.org/articles/PMC2715636/
Autor:
Steven M. Crespo-Carbone, Jamese J. Hilliard, Barbara D. Foleno, Raul Goldschmidt, Karen Bush, Sean Peng, Ellen Z. Baum, Darren Abbanat
Publikováno v:
Antimicrobial agents and chemotherapy. 49(11)
The enzyme l , d -carboxypeptidase A is involved in the recycling of bacterial peptidoglycan and is essential in Escherichia coli during stationary phase. By high-throughput screening, we have identified a dithiazoline inhibitor of the enzyme with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a773dded1c0a1fd302b1e2dfc0a4854c
https://pubmed.ncbi.nlm.nih.gov/16251288
https://pubmed.ncbi.nlm.nih.gov/16251288
Autor:
Suzie Chen, Pamela M. Pollock, Jeffrey J. Martino, Raman Sood, Karen J. Dunn, Kerine R. Mackason, James S. Goydos, Christiane M. Robbins, Kevin Ryan, William J. Pavan, Michael Eckhaus, Steven M. Crespo-Carbone, Christopher L. Graham, Yarí E. Marín, Jun Cheng, Daniel Sinsimer, Jin Namkoong, Arturo Incao, Kenneth R. Reuhl, Jeffrey M. Trent, Izabela Makalowska, Amy Chen, Kathleen G. Roberts, Laura M. Yudt, Aruna Koganti, Heather W. Pinkett, Paul S. Meltzer, Seung Shick Shin, Hua Zhu, Karine A. Cohen-Solal
Publikováno v:
Nature genetics. 34(1)
To gain insight into melanoma pathogenesis, we characterized an insertional mouse mutant, TG3, that is predisposed to develop multiple melanomas. Physical mapping identified multiple tandem insertions of the transgene into intron 3 of Grm1 (encoding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f92780953cdce9df58bcdf807a24c69
https://pubmed.ncbi.nlm.nih.gov/12704387
https://pubmed.ncbi.nlm.nih.gov/12704387
Autor:
Jin Namkoong, Kerine R. Mackason, Karine A. Cohen-Solal, Kenneth R. Reuhl, Steven M. Crespo-Carbone, Kathleen G. Roberts, Suzie Chen
Publikováno v:
Pigment cell research. 15(4)
We previously described a transgenic mouse line (TG-3) that spontaneously develops pigmented cutaneous melanoma. The generation of several albino mice that developed amelanotic melanoma has also been reported. In this report, we describe an unanticip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1e5c0c2ec32677d523876cffecde39d
https://pubmed.ncbi.nlm.nih.gov/12100494
https://pubmed.ncbi.nlm.nih.gov/12100494