Zobrazeno 1 - 10 of 142 pro vyhledávání: '"Steven M. Chan"'
2
Akademický článek
Outcomes and adverse events in older acute lymphoblastic Leukemia patients treated with a pediatric-inspired protocol with Pegylated or native Asparaginase
Autor: Maria Agustina Perusini, Claire Andrews, Eshetu G. Atenafu, Vikas Gupta, Dawn Maze, Andre C. Schuh, Karen WL. Yee, Aniket Bankar, Marta B. Davidson, Guillaume Richard-Carpentier, Steven M. Chan, Jad Sibai, Aaron D. Schimmer, Mark D. Minden, Hassan Sibai
Publikováno v: Hematology, Vol 29, Iss 1 (2024)
ABSTRACTThis retrospective report presents the outcomes and adverse events (AEs) observed in 73 patients aged 60 years or older diagnosed with Philadelphia Chromosome-negative Acute Lymphoblastic Leukemia (Ph-negative ALL) treated with a pediatric-in
Externí odkaz: https://doaj.org/article/860fe86b5d6c425b93b7c8cf45f165fa
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3
Akademický článek
Safety of re‐challenging adults with acute lymphoblastic leukemia with PEG‐asparaginase‐induced severe hypertriglyceridemia when treated with a pediatric‐inspired regimen
Autor: Ibrahim Al Nabhani, Claire Andrews, Jad Sibai, Eshetu Atenafu, Taylor Young, Steven M. Chan, Vikas Gupta, Dawn Maze, Aaron D. Schimmer, Andre C. Schuh, Karen Yee, Hassan Sibai
Publikováno v: eJHaem, Vol 4, Iss 1, Pp 232-235 (2023)
Abstract PEG‐asparaginase is used as a treatment for Philadelphia‐negative acute lymphoblastic leukemia. In pediatric studies, triglycerides (TGs) were affected more by PEG‐asparaginase than by native L‐asparaginase (10.0% vs. 5.5%). We condu
Externí odkaz: https://doaj.org/article/e50e7e9e08b74513abd28ce4a7d9068c
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5
Akademický článek
Risk of Thrombosis in Adult Philadelphia-Positive ALL Treated with an Asparaginase-Free ALL Regimen
Autor: Ruiqi Chen, Xing Liu, Arjun D. Law, Solaf Kanfar, Dawn Maze, Steven M. Chan, Vikas Gupta, Karen W. Yee, Mark D. Minden, Aaron D. Schimmer, Andre C. Schuh, Caroline J. McNamara, Tracy Murphy, Anna Xu, Umberto Falcone, Jack Seki, Hassan Sibai
Publikováno v: Current Oncology, Vol 28, Iss 1, Pp 128-137 (2020)
Background: venous thromboembolism (VTE) is a well-known complication in adults with acute lymphoblastic leukemia (ALL), especially in patients treated with asparaginase (ASNase)-including regiments. However, VTE risk in adult Philadelphia-positive A
Externí odkaz: https://doaj.org/article/52f8617b934048549a4137619b3d7db4
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7
Akademický článek
Repurposing ribosome-targeting antibiotics to overcome resistance to venetoclax in acute myeloid leukemia
Autor: David Sharon, Steven M. Chan
Publikováno v: Molecular & Cellular Oncology, Vol 7, Iss 2 (2020)
Venetoclax, a selective B-cell lymphoma 2 inhibitor, has shown promise in the treatment of acute myeloid leukemia. However, the development of drug resistance limits its clinical efficacy. In our study, we discovered that ribosome-targeting antibioti
Externí odkaz: https://doaj.org/article/2515d552abf14b64acef7ecf20feb17a
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8
Akademický článek
Intensive serial biomarker profiling for the prediction of neutropenic fever in patients with hematologic malignancies undergoing chemotherapy: a pilot study
Autor: Steven M. Chan, John Chadwick, Daniel L. Young, Elizabeth Holmes, Jason Gotlib
Publikováno v: Hematology Reports, Vol 6, Iss 2 (2014)
Neutropenic fever (NF) is a life-threatening complication of myelosuppressive chemotherapy in patients with hematologic malignancies and triggers the administration of broad-spectrum antimicrobials. The ability to accurately predict NF would permit i
Externí odkaz: https://doaj.org/article/44851bfdf2f14514af480e0c590b506a
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