The Chk1/Cdc25A Pathway as Activators of the Cell Cycle in Neuronal Death Induced by Camptothecin

Autor: Ruth S. Slack, Steven M. Callaghan, Herbert M. Geller, David S. Park, Erick J. Morris, Yi Zhang, Michael J. O'Hare, Dianbo Qu

Publikováno v: The Journal of Neuroscience. 26:8819-8828

Cell cycle regulators appear to play a paradoxical role in neuronal death. We have shown previously that cyclin-dependent kinases (CDKs), along with their downstream effectors, Rb (retinoblastoma) and E2F/DP1 (E2 promoter binding factor/deleted in po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::756c4c30fa4fcf33fb296bd6a9f8cc3c
https://doi.org/10.1523/jneurosci.2593-06.2006

Multiple cyclin-dependent kinases signals are critical mediators of ischemia/hypoxic neuronal death in vitro and in vivo

Autor: Ross J. Bland, Inez Vincent, Mario Rios, Juliet Rashidian, Grace O. Iyirhiaro, Steven M. Callaghan, David S. Park, Matthew J. During, Hossein Aleyasin, Ruth S. Slack

Publikováno v: Proceedings of the National Academy of Sciences. 102:14080-14085

The mechanisms involving neuronal death after ischemic/hypoxic insult are complex, involving both rapid (excitotoxic) and delayed (apoptotic-like) processes. Recent evidence suggests that cell cycle regulators such as cyclin-dependent kinases are abn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::098c8bf70572f2c86f40a7e0c5b21da9
https://doi.org/10.1073/pnas.0500099102

c-Jun mediates axotomy-induced dopamine neuron death in vivo

Autor: Steven M. Callaghan, Patrice D. Smith, Stephen J. Crocker, Ruth S. Slack, David S. Park, Hymie Anisman, Wiplove R. Lamba

Publikováno v: Proceedings of the National Academy of Sciences. 98:13385-13390

Expression of the transcription factor c-Jun is induced in neurons of the central nervous system (CNS) in response to injury. Mechanical transection of the nigrostriatal pathway at the medial forebrain bundle (MFB) results in the delayed retrograde d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::767431cfedaf93c6b998a63ab5e5ac4b
https://doi.org/10.1073/pnas.231177098

Helper-dependent adenovirus vectors: their use as a gene delivery system to neurons

Autor: T F Gendron, Robin J. Parks, Sean P. Cregan, Frank L. Graham, Paul Morley, Steven M. Callaghan, Jason G. MacLaurin, Ruth S. Slack, David S. Park

Publikováno v: Gene Therapy. 7:1200-1209

Recombinant adenovirus vectors have provided a major advance in gene delivery systems for post-mitotic neurons. However, the use of these first generation vectors has been limited due to the onset of virally mediated effects on cellular function and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51e9f31b3ca095a74cd29a70442beb79
https://doi.org/10.1038/sj.gt.3301208

Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics

Autor: Tak W. Mak, Steven M. Callaghan, Heidi M. McBride, Ruth S. Slack, Hossein Aleyasin, Arezu Jahani-Asl, Raymond H. Kim, Sarah Hewitt, David S. Park, Carol X.-Q. Chen, Erin L. Seifert, Patrizia Rizzu, S. Chhabra, Mary-Ellen Harper, Maryam Phillips, Anne Kathrin Lutz, Maxime W.C. Rousseaux, Isabella Irrcher, Peter Rippstein, Jason G. MacLaurin, Lisa Bevilacqua, Edward A. Fon, Konstanze F. Winklhofer

Publikováno v: Human Molecular Genetics, 19(19), 3734-3746. Oxford University Press
Irrcher, I, Aleyasin, H, Seifert, E L, Hewitt, S J, Chhabra, S, Phillips, M, Lutz, A K, Rousseaux, M W C, Bevilacqua, L, Jahani-Asl, A, Callaghan, S, MacLaurin, J G, Winklhofer, K F, Rizzu, P, Rippstein, P, Kim, R H, Chen, C X, Fon, E A, Slack, R S, Harper, M E, McBride, H M, Mak, T W & Park, D S 2010, ' Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics ', Human Molecular Genetics, vol. 19, no. 19, pp. 3734-3746 . https://doi.org/10.1093/hmg/ddq288

Growing evidence highlights a role for mitochondrial dysfunction and oxidative stress as underlying contributors to Parkinson’s disease (PD) pathogenesis. DJ-1 (PARK7) is a recently identified recessive familial PD gene. Its loss leads to increased

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e050c2cfec6f68f5aef943f14c2cb29
https://pubmed.ncbi.nlm.nih.gov/20639397