Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Steven M. Bryce"'
Publikováno v:
Mutagenesis
The desire for in vitro genotoxicity assays to provide higher information content, especially regarding chemicals’ predominant genotoxic mode of action, has led to the development of a novel multiplexed assay available under the trade name MultiFlo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a19e3b9eae7e1fc866b47b48792ff84d
https://doi.org/10.1093/mutage/geab014
https://doi.org/10.1093/mutage/geab014
Publikováno v:
Environ Mol Mutagen
This laboratory previously described an in vitro human cell-based assay and data analysis scheme that discriminates common molecular targets responsible for chemical-induced in vitro aneugenicity: tubulin destabilization, tubulin stabilization, and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a945b638ceb6a65b4066a37b27897995
https://europepmc.org/articles/PMC9106857/
https://europepmc.org/articles/PMC9106857/
Autor:
Aiyana Cyr, Shuchang Tian, Steven M. Bryce, Jeffrey C. Bemis, Karen Zeise, Stephen D. Dertinger, Nikki E. Hall
Publikováno v:
Environmental and Molecular Mutagenesis. 61:408-432
MultiFlow® DNA Damage-p53, γH2AX, Phospho-Histone H3 is a miniaturized, flow cytometry-based assay that provides genotoxic mode of action information by distinguishing clastogens, aneugens, and nongenotoxicants. Work to date has focused on the p53-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::233bcb2245953a2611adc81b78c74436
https://doi.org/10.1002/em.22361
https://doi.org/10.1002/em.22361
Autor:
Jeffrey C. Bemis, George E. Johnson, Derek T. Bernacki, Stephen D. Dertinger, Ryan P Wheeldon, Steven M. Bryce
Publikováno v:
Environmental and Molecular Mutagenesis. 61:396-407
Genetic toxicology data have traditionally been utilized for hazard identification to provide a binary call for a compound's risk. Recent advances in the scientific field, especially with the development of high-throughput methods to quantify DNA dam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7ce94d592675bec87520529ea04192f
https://doi.org/10.1002/em.22360
https://doi.org/10.1002/em.22360
Autor:
Tina Pellegrin, Peter Bajorski, Manali Godse, Stephen D. Dertinger, Steven M. Bryce, Jeffrey C. Bemis, Svetlana L. Avlasevich
Publikováno v:
Mutagenesis
We have previously described two flow cytometry-based in vitro genotoxicity tests: micronucleus (MN) scoring (MicroFlow®) and a multiplexed DNA damage response biomarker assay (MultiFlow®). Here, we describe a strategy for combining the assays in o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13c4542717676155b02d6ee774d33580
https://europepmc.org/articles/PMC8633886/
https://europepmc.org/articles/PMC8633886/
Autor:
Derek T. Bernacki, Stephanie L. Smith-Roe, Steven M. Bryce, Stephen D. Dertinger, Jeffrey C. Bemis, Kristine L. Witt
Publikováno v:
Environmental and Molecular Mutagenesis
Black cohosh extract (BCE) is a popular botanical dietary supplement marketed to relieve symptoms of various gynecological ailments. Studies conducted by the National Toxicology Program (NTP) showed that BCE induces micronucleated erythrocytes in fem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::311cd7e5adb428234d01537ee5c59d97
https://doi.org/10.1002/em.22334
https://doi.org/10.1002/em.22334
Autor:
Sheila M. Galloway, Steven M. Bryce, Nikki E. Hall, Derek T. Bernacki, Jeffrey C. Bemis, Andrew R. Kraynak, Ryan P Wheeldon, Patricia A. Escobar, Stephen D. Dertinger, George E. Johnson
Publikováno v:
Environmental and Molecular Mutagenesis. 60:513-533
The in vitro MultiFlow® DNA Damage Assay multiplexes γH2AX, p53, phospho-histone H3, and polyploidization biomarkers into a single flow cytometric analysis. The current report describes a tiered sequential data analysis strategy based on data gener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11c8687327a0ad6504c7bc03223d67ad
https://doi.org/10.1002/em.22274
https://doi.org/10.1002/em.22274
The Benchmark Dose (BMD) method is the favored approach for quantitative dose-response analysis where uncertainty measurements are delineated between the upper (BMDU) and lower (BMDL) confidence bounds, or confidence intervals (CIs). Little has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a14db34f3bba340cd6a846d8353b7c5
https://cronfa.swan.ac.uk/Record/cronfa56076/Download/56076__19181__eb84a9f54d9d43ce863726d100a51223.pdf
https://cronfa.swan.ac.uk/Record/cronfa56076/Download/56076__19181__eb84a9f54d9d43ce863726d100a51223.pdf
Autor:
Carol D. Swartz, Steven M. Bryce, Kristine L. Witt, Scott S. Auerbach, Stephanie L. Smith-Roe, Grace E. Kissling, Stephen D. Dertinger, Kim G. Shepard, Suramya Waidyanatha
Publikováno v:
Environmental and Molecular Mutagenesis. 59:416-426
Black cohosh extract (BCE) is a widely used dietary supplement marketed to women to alleviate symptoms of gynecological ailments, yet its toxicity has not been well characterized. The National Toxicology Program (NTP) previously reported significant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f33d894286f107dd0e9d666658221aa
https://doi.org/10.1002/em.22182
https://doi.org/10.1002/em.22182
Autor:
Jenna A Tan, Xiaoqing Guo, Martha M. Moore, Steven M. Bryce, Qiangen Wu, Nan Mei, Ji-Eun Seo, Stacey L. Dial
Publikováno v:
Toxicological Sciences. 163:214-225
TEMPO (2, 2, 6, 6-tetramethylphiperidine-1-oxyl) and its derivatives are stable free radical nitroxides widely used in the field of chemistry, biology, and pharmacology. TEMPO was previously found to be mutagenic and to induce micronuclei in mammalia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ece32ab45367496234e792880115fb1
https://doi.org/10.1093/toxsci/kfy022
https://doi.org/10.1093/toxsci/kfy022