Výsledky vyhledávání - "Steven M. Ansell"

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

Autor: Sean C. Semple, Xinyao Du, Barbara L. Mui, Akin Akinc, Muthusamy Jayaraman, Roy van der Meel, Jayesh A. Kulkarni, Martin Maier, Thomas D. Madden, Scott A Barros, Kevin Fitzgerald, Pieter R. Cullis, Muthiah Manoharan, Steven M. Ansell, Marco A. Ciufolini, Ying K. Tam, Michael J. Hope, Dominik Witzigmann

Publikováno v: Nature Nanotechnology, 14(12), 1084-1087. Nature Publishing Group

The regulatory approval of Onpattro, a lipid nanoparticle-based short interfering RNA drug for the treatment of polyneuropathies induced by hereditary transthyretin amyloidosis, paves the way for clinical development of many nucleic acid-based therap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7b1dbcf1b6ee973cd6b84f585fddab5
https://doi.org/10.1038/s41565-019-0591-y

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Akademický článek

Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles

Autor: Barbara L Mui, Ying K Tam, Muthusamy Jayaraman, Steven M Ansell, Xinyao Du, Yuen Yi C Tam, Paulo JC Lin, Sam Chen, Jayaprakash K Narayanannair, Kallanthottathil G Rajeev, Muthiah Manoharan, Akin Akinc, Martin A Maier, Pieter Cullis, Thomas D Madden, Michael J Hope

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 2, Iss C (2013)

Lipid nanoparticles (LNPs) encapsulating short interfering RNAs that target hepatic genes are advancing through clinical trials, and early results indicate the excellent gene silencing observed in rodents and nonhuman primates also translates to huma

Externí odkaz: https://doaj.org/article/f5677ebf4c334dbe9c9d38a4979393bb

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Effects of block copolymer properties on nanocarrier protection from in vivo clearance

Autor: Steven M. Ansell, Douglas H. Adamson, Robert K. Prud'homme, Lawrence D. Mayer, Walid Saad, Adam R. Wohl, John J. Squiers, Christopher W. Macosko, Suzanne M. D'Addio, Thomas R. Hoye, Christine Vauthier, Margarita Herrera-Alonso

Publikováno v: Journal of Controlled Release. 162:208-217

Drug nanocarrier clearance by the immune system must be minimized to achieve targeted delivery to pathological tissues. There is considerable interest in finding in vitro tests that can predict in vivo clearance outcomes. In this work, we produce nan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f01deaffa9b4d307aaaa26aab06af63
https://doi.org/10.1016/j.jconrel.2012.06.020

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Methods for the Preparation of Protein−Oligonucleotide−Lipid Constructs

Autor: Ghania Chikh, Laura Sekirov, Jennifer Takasaki, Steven M. Ansell, Sameersingh G. Raney, Ying Tam, Irina Brodsky

Publikováno v: Bioconjugate Chemistry. 17:451-458

A mixture of ionizable cationic lipids, steric barrier lipids, and colipids is used to encapsulate oligonucleotide DNA in lipidic particles called SALP. This material is under development as an adjuvant for vaccines. Previously we have shown that cou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b8c8a686c08513f658958ae45f756ac
https://doi.org/10.1021/bc050052j

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Immunogenicity and Rapid Blood Clearance of Liposomes Containing Polyethylene Glycol-Lipid Conjugates and Nucleic Acid

Autor: Michael J. Hope, Kathy A Clow, Steven M. Ansell, Sandra K. Klimuk, Sean C. Semple, Troy Harasym

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 312:1020-1026

Polyethylene glycol (PEG) is used widely in the pharmaceutical industry to improve the pharmacokinetics and reduce the immunogenicity of therapeutic and diagnostic agents. The incorporation of lipid-conjugated PEG into liposomal drug delivery systems

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1511d3032b0414dc84c88d3ea2cd12ed
https://doi.org/10.1124/jpet.104.078113

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Synthesis of Polyamide Oligomers Based on 14-Amino-3,6,9,12-tetraoxatetradecanoic Acid

Autor: Michael Feng, Rajiv Dhawan, Mark G. A. Kadijk, Steven M. Ansell, Terry J. Joikinen

Publikováno v: Bioconjugate Chemistry. 11:14-21

A series of oligomers of polyamides based on 14-amino-3,6,9, 12-tetraoxatetradecanoic acid monomers (ATTAn) was synthesized. These materials were designed as monodisperse analogues of poly(ethylene glycol) for use in biomedical applications where rep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2dfa11ff5fc953f7634caf81debc978
https://doi.org/10.1021/bc9801427

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Application of Oligo-(14-amino-3,6,9,12-tetraoxatetradecanoic acid) Lipid Conjugates as Steric Barrier Molecules in Liposomal Formulations

Autor: Dora K. Lee, Laura Sekirov, Ljiljana D. Kojic, Steven M. Ansell, Anthony Boey, Nancy Dos Santos, Sandra K. Klimuk, Troy Harasym, Sean C. Semple, Janet S. Hankins, Athena R. Bennett

Publikováno v: Bioconjugate Chemistry. 10:653-666

Lipid conjugates of oligo-(14-amino-3,6,9,12-tetraoxatetradecanoic acid) (ATTAn) were synthesized as monodisperse analogues of poly(ethylene glycol) (PEG) derivatives used in liposomal drug delivery systems. The new lipids were shown to be at least e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41bcd4c1209c8326a9a52fb0ba51f4ae
https://doi.org/10.1021/bc990005p

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Inhibition of Liposome-Induced Complement Activation by Incorporated Poly(Ethylene Glycol)-Lipids

Autor: Donald E. Brooks, Johan Janzen, Steven M. Ansell, Dana V. Devine, Amanda J. Bradley

Publikováno v: Archives of Biochemistry and Biophysics. 357:185-194

Complement activation causes opsonization of foreign particles leading to particle elimination from the blood. Complement-mediated opsonization of charged and large liposomes presents a fundamental problem in their use to deliver therapeutic agents i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e61555935feade27958e18c77b37f47c
https://doi.org/10.1006/abbi.1998.0798

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Liposome Targeting Following Intravenous Administration: Defining Expectations and a Need for Improved Methodology

Autor: Paul Tardi, Troy Harasym, Steven M. Ansell, Marcel B. Bally

Publikováno v: Journal of Liposome Research. 7:331-361

The prospects for developing improved liposome based anti-cancer drug formulations are great, particularly when considering the potential role of lipid-based formulations for delivery of biopharmaceuticals. It is important however, to pursue improved

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a8bf6800a7d8b1b85097fd6997a3bf5
https://doi.org/10.3109/08982109709035507

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3-(2-Pyridyldithio)propionic Acid Hydrazide as a Cross-Linker in the Formation of Liposome−Antibody Conjugates

Autor: Steven M. Ansell, Susan S. Buchkowsky, Paul Tardi

Publikováno v: Bioconjugate Chemistry. 7:490-496

Liposome antibody conjugates are potentially useful as a means of targeting drugs to specific tissues. A new protocol for the conjugation of IgG to maleimide-containing liposomes was developed using 3-(2-pyridyldithio)propionic acid hydrazide (PDPH)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9db15fa52be470337999399f7dc0bff0
https://doi.org/10.1021/bc960036+

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