Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Steven M Lewis"'
Autor:
Julia Koehler Leman, Brian D Weitzner, P Douglas Renfrew, Steven M Lewis, Rocco Moretti, Andrew M Watkins, Vikram Khipple Mulligan, Sergey Lyskov, Jared Adolf-Bryfogle, Jason W Labonte, Justyna Krys, RosettaCommons Consortium, Christopher Bystroff, William Schief, Dominik Gront, Ora Schueler-Furman, David Baker, Philip Bradley, Roland Dunbrack, Tanja Kortemme, Andrew Leaver-Fay, Charlie E M Strauss, Jens Meiler, Brian Kuhlman, Jeffrey J Gray, Richard Bonneau
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 5, p e1007507 (2020)
Many scientific disciplines rely on computational methods for data analysis, model generation, and prediction. Implementing these methods is often accomplished by researchers with domain expertise but without formal training in software engineering o
Externí odkaz:
https://doaj.org/article/39b3fd5bfd834abfb5347fc6af6789bc
Autor:
Jamie L Harden, Steven M Lewis, Katherine C Pierson, Mayte Suárez-Fariñas, Tim Lentini, Francesca S Ortenzio, Lisa C Zaba, Raphaela Goldbach-Mansky, Anne M Bowcock, Michelle A Lowes
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e111255 (2014)
Mutations in the caspase recruitment domain, family member 14 (CARD14) gene have recently been described in psoriasis patients, and explain the psoriasis susceptibility locus 2 (PSORS2). CARD14 is a scaffolding protein that regulates NF-κB activatio
Externí odkaz:
https://doaj.org/article/d6cdeb15b9694502ba56d2fcab0f63f8
Autor:
Hari B Kamadurai, Yu Qiu, Alan Deng, Joseph S Harrison, Chris MacDonald, Marcelo Actis, Patrick Rodrigues, Darcie J Miller, Judith Souphron, Steven M Lewis, Igor Kurinov, Naoaki Fujii, Michal Hammel, Robert Piper, Brian Kuhlman, Brenda A Schulman
Publikováno v:
eLife, Vol 2 (2013)
Ubiquitination by HECT E3 enzymes regulates myriad processes, including tumor suppression, transcription, protein trafficking, and degradation. HECT E3s use a two-step mechanism to ligate ubiquitin to target proteins. The first step is guided by inte
Externí odkaz:
https://doaj.org/article/ee078a0126a4411894d3182965482e78
Autor:
Andrew C Hemmert, Tamara C Otto, Roberto A Chica, Monika Wierdl, Jonathan S Edwards, Steven M Lewis, Carol C Edwards, Lyudmila Tsurkan, C Linn Cadieux, Shane A Kasten, John R Cashman, Stephen L Mayo, Philip M Potter, Douglas M Cerasoli, Matthew R Redinbo
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17441 (2011)
Organophosphorus (OP) nerve agents are potent suicide inhibitors of the essential neurotransmitter-regulating enzyme acetylcholinesterase. Due to their acute toxicity, there is significant interest in developing effective countermeasures to OP poison
Externí odkaz:
https://doaj.org/article/cc3673771a9c4824bb65ae97a1dd1a81
Autor:
Steven M Lewis, Brian A Kuhlman
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20872 (2011)
Few existing protein-protein interface design methods allow for extensive backbone rearrangements during the design process. There is also a dichotomy between redesign methods, which take advantage of the native interface, and de novo methods, which
Externí odkaz:
https://doaj.org/article/1941e35254164cee87913447e9ef7dae
Autor:
Arielle Soldatenko, Laura R. Hoyt, Lan Xu, Samuele Calabro, Steven M. Lewis, Antonia E. Gallman, Krystalyn E. Hudson, Sean R. Stowell, Chance J. Luckey, James C. Zimring, Dong Liu, Manjula Santhanakrishnan, Jeanne E. Hendrickson, Stephanie C. Eisenbarth
Publikováno v:
The Journal of Immunology. 208:991-997
RBC transfusion therapy is essential for the treatment of anemia. A serious complication of transfusion is the development of non-ABO alloantibodies to polymorphic RBC Ags; yet, mechanisms of alloantibody formation remain unclear. Storage of mouse RB
Publikováno v:
Exp Biol Med (Maywood)
While mouse models and two-dimensional (2D) cell culture systems have dominated as research tools for cancer biology, three-dimensional (3D) cultures have gained traction as a new approach that retains features of in vivo biology within an in vitro s
Autor:
Stephanie C. Eisenbarth, Lan Xu, Krystalyn E. Hudson, James C. Zimring, Jeanne E. Hendrickson, Arielle Soldatenko, Sean R. Stowell, Chance John Luckey, Manjula Santhanakrishnan, Samuele Calabro, Steven M. Lewis, Laura R. Hoyt, Antonia Gallman, Dong Liu
Publikováno v:
J Immunol
Red blood cell (RBC) transfusion therapy is essential for the survival of patients with hematological disorders such as sickle cell anemia. A potentially fatal complication of transfusion is development of non-ABO alloantibodies to polymorphic RBC an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c0a0e045d41a78e66de439e6e0b3523
https://europepmc.org/articles/PMC10107373/
https://europepmc.org/articles/PMC10107373/
Autor:
Dominik Gront, Kresten Lindorff-Larsen, Jack Maguire, Jens Meiler, Christopher D. Bahl, Jason S. Fell, Chris Bailey-Kellogg, Andrew M. Watkins, Frank DiMaio, Daniel P. Farrell, Jared Adolf-Bryfogle, Julia Koehler Leman, Frank D. Teets, Vladimir Yarov-Yarovoy, Ajasja Ljubetič, Shannon T. Smith, William A. Hansen, Steven M. Lewis, Justyna Krys, Shourya S. Roy Burman, Amelie Stein, Rhiju Das, David Baker, Vikram Khipple Mulligan, Jason W. Labonte, Georg Kuenze, William R. Schief, Rebecca F. Alford, Shane Ó Conchúir, Hope Woods, Tanja Kortemme, Johanna K. S. Tiemann, Sagar D. Khare, Sergey Lyskov, Ziv Ben-Aharon, Ora Schueler-Furman, Amanda L. Loshbaugh, Richard Bonneau, Brahm J. Yachnin, Andrew Leaver-Fay, Kyle A. Barlow, Phuong T. Nguyen, Jeliazko R. Jeliazkov, Jeffrey J. Gray, Justin B. Siegel, Rocco Moretti, Ameya Harmalkar, Brian Kuhlman
Each year vast international resources are wasted on irreproducible research. The scientific community has been slow to adopt standard software engineering practices, despite the increases in high-dimensional data, complexities of workflows, and comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ae3b538a88ca76a15e111345bd76765
https://doi.org/10.1101/2021.04.04.438423
https://doi.org/10.1101/2021.04.04.438423
Autor:
Steven M. Lewis, Lisa Strano-Paul
Publikováno v:
Journal of the American Geriatrics Society. 69