Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Steven M Blue"'
Autor:
Hugo C. Medina-Munoz, Eric Kofman, Pratibha Jagannatha, Evan A. Boyle, Tao Yu, Krysten L. Jones, Jasmine R. Mueller, Grace D. Lykins, Andrew T. Doudna, Samuel S. Park, Steven M. Blue, Brodie L. Ranzau, Rahul M. Kohli, Alexis C. Komor, Gene W. Yeo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract RNA binding proteins (RBPs) are key regulators of RNA processing and cellular function. Technologies to discover RNA targets of RBPs such as TRIBE (targets of RNA binding proteins identified by editing) and STAMP (surveying targets by APOBEC
Externí odkaz:
https://doaj.org/article/8d2fba859be64189bf8bdb600ad90c27
Autor:
Waqar Arif, Bhoomika Mathur, Michael F. Saikali, Ullas V. Chembazhi, Katelyn Toohill, You Jin Song, Qinyu Hao, Saman Karimi, Steven M. Blue, Brian A. Yee, Eric L. Van Nostrand, Sushant Bangru, Grace Guzman, Gene W. Yeo, Kannanganattu V. Prasanth, Sayeepriyadarshini Anakk, Carolyn L. Cummins, Auinash Kalsotra
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Nonalcoholic steatohepatitis (NASH) is an advanced form of fatty liver disease with complex pathogenic mechanisms. Here, the authors report that SRSF1 deficiency in mice livers provokes deleterious R-loop formation and genotoxicity, which impedes hep
Externí odkaz:
https://doaj.org/article/ee830a8f79654480908b12970aefaf07
Autor:
Aidan M. Fenix, Yuichiro Miyaoka, Alessandro Bertero, Steven M. Blue, Matthew J. Spindler, Kenneth K. B. Tan, Juan A. Perez-Bermejo, Amanda H. Chan, Steven J. Mayerl, Trieu D. Nguyen, Caitlin R. Russell, Paweena P. Lizarraga, Annie Truong, Po-Lin So, Aishwarya Kulkarni, Kashish Chetal, Shashank Sathe, Nathan J. Sniadecki, Gene W. Yeo, Charles E. Murry, Bruce R. Conklin, Nathan Salomonis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Mutations in the splicing factor RBM20 cause aggressive Dilated Cardiomyopathy. Here the authors generated RBM20 R636S mutants and knockout in human iPSC-derived cardiomyocytes. Mutant RBM20 showed different target RNA binding, altered splicing and l
Externí odkaz:
https://doaj.org/article/f87c8729e80949bda7d8b7b816b64084
Autor:
Eric L. Van Nostrand, Gabriel A. Pratt, Brian A. Yee, Emily C. Wheeler, Steven M. Blue, Jasmine Mueller, Samuel S. Park, Keri E. Garcia, Chelsea Gelboin-Burkhart, Thai B. Nguyen, Ines Rabano, Rebecca Stanton, Balaji Sundararaman, Ruth Wang, Xiang-Dong Fu, Brenton R. Graveley, Gene W. Yeo
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-26 (2020)
Abstract Background A critical step in uncovering rules of RNA processing is to study the in vivo regulatory networks of RNA binding proteins (RBPs). Crosslinking and immunoprecipitation (CLIP) methods enable mapping RBP targets transcriptome-wide, b
Externí odkaz:
https://doaj.org/article/7bd753fbac7546c7ad4fb5a7375a17e9
Publikováno v:
STAR Protocols, Vol 2, Iss 3, Pp 100762- (2021)
Summary: Selective 2′-hydroxyl acylation analyzed by primer extension (SHAPE) structure probing techniques characterize the secondary structure of RNA molecules, which influence their functions and interactions. A variation of SHAPE, footprinting S
Externí odkaz:
https://doaj.org/article/9b2ac54000f94ebe9fde6319b126b28e
Autor:
Louis Philip Benoit Bouvrette, Xiaofeng Wang, Jonathan Boulais, Jian Kong, Easin Uddin Syed, Steven M Blue, Lijun Zhan, Sara Olson, Rebecca Stanton, Xintao Wei, Brian Yee, Eric L Van Nostrand, Xiang-Dong Fu, Christopher B Burge, Brenton R Graveley, Gene W Yeo, Eric Lécuyer
Publikováno v:
Nucleic Acids Research. 51:D1549-D1557
RNA binding proteins (RBPs) are central regulators of gene expression implicated in all facets of RNA metabolism. As such, they play key roles in cellular physiology and disease etiology. Since different steps of post-transcriptional gene expression
Autor:
Stefan G. Kathman, Seong Joo Koo, Garrett L. Lindsey, Hsuan-Lin Her, Steven M. Blue, Haoxin Li, Steffen Jaensch, Jarrett R. Remsberg, Kay Ahn, Gene W. Yeo, Brahma Ghosh, Benjamin F. Cravatt
Publikováno v:
Nature Chemical Biology.
Autor:
Steven M. Blue, Brian A. Yee, Gabriel A. Pratt, Jasmine R. Mueller, Samuel S. Park, Alexander A. Shishkin, Anne C. Starner, Eric L. Van Nostrand, Gene W. Yeo
Publikováno v:
Nature Protocols. 17:1223-1265
Autor:
Gabriel A. Pratt, Shashank Sathe, Neal A.L. Cody, Ruth Wang, Xiaofeng Wang, Peter Freese, Keri E. Garcia, Ashley L. Louie, Eric Lécuyer, Cassandra Bazile, Xintao Wei, Steven M. Blue, Rebecca Stanton, Myles Hochman, Daniel Dominguez, Balaji Sundararaman, Eric L. Van Nostrand, Michael O. Duff, Jia-Yu Chen, Nicole J. Lambert, Amanda Su, Julie Bergalet, Stefan Aigner, Tsultrim Palden, Ines Rabano, Xiang-Dong Fu, Hairi Li, Brenton R. Graveley, Chelsea Gelboin-Burkhart, Lijun Zhan, Bing Zhou, Gene W. Yeo, Christopher B. Burge, Thai B. Nguyen, Rui Xiao, Michael P. McGurk, Louis Philip Benoit Bouvrette, Brian A. Yee, Sara Olson
Publikováno v:
Nature, vol 583, iss 7818
Nature
Nature
Many proteins regulate the expression of genes by binding to specific regions encoded in the genome1. Here we introduce a new data set of RNA elements in the human genome that are recognized by RNA-binding proteins (RBPs), generated as part of the En
Autor:
Trey Ideker, J. Wade Harper, John J. Lee, Steven P. Gygi, Laura Pontano Vaites, Denis L. J. Lafontaine, Edward L. Huttlin, Erica Silva, Michael Chen, Jason F. Kreisberg, Casper F. Winsnes, Fan Zheng, Leah V. Schaffer, Gene W. Yeo, Tian Zhang, Wei Ouyang, Anna Bäckström, Katherine Licon, Jisoo Park, Jianzhu Ma, Emma Lundberg, Maya L. Gosztyla, Yue Qin, Steven M. Blue, Adriana Pitea, Sophie Liu, Ludivine Wacheul, Marcus R. Kelly
Publikováno v:
Nature, vol 600, iss 7889
Nature
Nature
The cell is a multi-scale structure with modular organization across at least four orders of magnitude(1). Two central approaches for mapping this structure—protein fluorescent imaging and protein biophysical association—each generate extensive d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e8d0c903c0d98dbe86f611fad1f98ee
https://escholarship.org/uc/item/9d15g18z
https://escholarship.org/uc/item/9d15g18z