Zobrazeno 1 - 10
of 172
pro vyhledávání: '"Steven M Block"'
Publikováno v:
eLife, Vol 4 (2015)
The thiamine pyrophosphate (TPP) riboswitch is a cis-regulatory element in mRNA that modifies gene expression in response to TPP concentration. Its specificity is dependent upon conformational changes that take place within its aptamer domain. Here,
Externí odkaz:
https://doaj.org/article/50e615842bf24d379d6461b505b5e887
Autor:
Johan OL Andreasson, Bojan Milic, Geng-Yuan Chen, Nicholas R Guydosh, William O Hancock, Steven M Block
Publikováno v:
eLife, Vol 4 (2015)
Kinesin-1 is a dimeric motor that transports cargo along microtubules, taking 8.2-nm steps in a hand-over-hand fashion. The ATP hydrolysis cycles of its two heads are maintained out of phase by a series of gating mechanisms, which lead to processive
Externí odkaz:
https://doaj.org/article/83ab9678951646c7be4c7c9bd14a6bcc
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
RNA sequence-structure-function relationships can be studied via assays of variant activity. The authors developed a method to systematically determine ribozyme variant kinetics, using it to map double-mutant interactions and show that cleavage rate
Externí odkaz:
https://doaj.org/article/bd2de6930e9143e08b42ce2dd005876a
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Contacts between RNA polymerase and promoter DNA modulate the strength of binding and the frequency of promoter escape during transcription. Here, the authors describe a single molecule optical-trapping assay to study transcription initiation and obs
Externí odkaz:
https://doaj.org/article/3bd3119120af44ce91cb96c3a3fcba13
Publikováno v:
Nature communications, vol 11, iss 1
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Massively parallel, quantitative measurements of biomolecular activity across sequence space can greatly expand our understanding of RNA sequence-function relationships. We report the development of an RNA-array assay to perform such measurements and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4626c73fc88e13b4f6bbfc5a0585352
https://escholarship.org/uc/item/7tz0p2xn
https://escholarship.org/uc/item/7tz0p2xn
Autor:
Steven M. Block, Andrew Savinov
Publikováno v:
Proceedings of the National Academy of Sciences. 115:11976-11981
Significance Riboswitches are structured mRNA elements that regulate gene expression in response to metabolite ligands. The bacterial glmS riboswitch regulates a protein with a key role in cell wall biosynthesis. This riboswitch follows an unusual me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3128de423a2c670ec00426ac969ce632
https://doi.org/10.1073/pnas.1812122115
https://doi.org/10.1073/pnas.1812122115
Publikováno v:
Biophysical Journal. 120:286a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bff72d7c47778a9a3b033a8b811a5dbd
https://doi.org/10.1016/j.bpj.2020.11.1835
https://doi.org/10.1016/j.bpj.2020.11.1835
Autor:
Andrew, Savinov, Steven M, Block
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(47)
Riboswitches modulate gene expression in response to small-molecule ligands. Switching is generally thought to occur via the stabilization of a specific RNA structure conferred by binding the cognate ligand. However, it is unclear whether any such st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::34e5ab0ff8cd973d1700bd762745eedc
https://pubmed.ncbi.nlm.nih.gov/30397151
https://pubmed.ncbi.nlm.nih.gov/30397151
Autor:
Roberta E. Sonnino, Steven M. Block, Thomas R. Viggiano, Valerie N. Williams, Darshana T. Shah, Luanne E. Thorndyke, E. Eugene Marsh
Increasing rates of burnout—with accompanying stress and lack of engagement—among faculty, residents, students, and practicing physicians have caused alarm in academic medicine. Central to the debate among academic medicine’s stakeholders are o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d25ffaf3f1f7c088694467ed4879b92
https://europepmc.org/articles/PMC6169302/
https://europepmc.org/articles/PMC6169302/
Publikováno v:
Proceedings of the National Academy of Sciences. 115
Eg5, a mitotic kinesin, has been a target for anticancer drug development. Clinical trials of small-molecule inhibitors of Eg5 have been stymied by the development of resistance, attributable to mitotic rescue by a different endogenous kinesin, KIF15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ba282db6db5bc6ef9be66823e123399
https://doi.org/10.1073/pnas.1801242115
https://doi.org/10.1073/pnas.1801242115