Zobrazeno 1 - 10
of 196
pro vyhledávání: '"Steven M, Swanson"'
Autor:
Christopher J. Unterberger, Sean J. McIlwain, Philippos K. Tsourkas, Vilena I. Maklakova, Jordyn L. Prince, Abigail Onesti, Rong Hu, John J. Kopchick, Steven M. Swanson, Paul C. Marker
Publikováno v:
The Prostate. 83:416-429
Humans with inactivating mutations in growth hormone receptor (GHR) have lower rates of cancer, including prostate cancer. Similarly, mice with inactivating Ghr mutations are protected from prostatic intraepithelial neoplasia in the C3(1)/TAg prostat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d15725ae900bb4415e6e2a0546a4e037
https://doi.org/10.1002/pros.24474
https://doi.org/10.1002/pros.24474
Autor:
Lauren Repp, Christopher J. Unterberger, Zhengqing Ye, John B. Feltenberger, Steven M. Swanson, Paul C. Marker, Glen S. Kwon
Publikováno v:
Nanomaterials, Vol 11, Iss 10, p 2745 (2021)
Docetaxel (DTX) is among the most frequently prescribed chemotherapy drugs and has recently been shown to extend survival in advanced prostate cancer patients. However, the poor water solubility of DTX prevents full exploitation of this potent antica
Externí odkaz:
https://doaj.org/article/1aee56640a144de084baf3208fc1ab00
Autor:
Joanna E. Burdette, James R. Fuchs, Leslie N. Aldrich, Mitch A. Phelps, Xiaoli Zhang, A. Douglas Kinghorn, Steven M. Swanson, Hongyan Wang, Salane King, Christopher C. Coss, Shamalatha Kolli, Sarmistha Mazumder, Daniel D. Lantvit, Melissa A. Korkmaz, Andrew C. Huntsman, Denisse Herrera, Alexandria N. Young
SF1: Synthesis & characterization of PHYs, SF2: Purity of PHYs, SF3: PHY34 cytotoxicity in various cancer types, SF4: Additional in vivo data, SF5: PHY25 & 30 cytotoxicity time course.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4414ea5e9f72b816d205eb53b72b7ebd
https://doi.org/10.1158/1535-7163.22504809
https://doi.org/10.1158/1535-7163.22504809
Autor:
Joanna E. Burdette, James R. Fuchs, Leslie N. Aldrich, Mitch A. Phelps, Xiaoli Zhang, A. Douglas Kinghorn, Steven M. Swanson, Hongyan Wang, Salane King, Christopher C. Coss, Shamalatha Kolli, Sarmistha Mazumder, Daniel D. Lantvit, Melissa A. Korkmaz, Andrew C. Huntsman, Denisse Herrera, Alexandria N. Young
High-grade serous ovarian cancer (HGSOC) is a lethal gynecological malignancy with a need for new therapeutics. Many of the most widely used chemotherapeutic drugs are derived from natural products or their semi-synthetic derivatives. We have develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edfc145fe4413a848e2a021faf5379ce
https://doi.org/10.1158/1535-7163.c.6537858.v1
https://doi.org/10.1158/1535-7163.c.6537858.v1
Publikováno v:
Endocr Relat Cancer
Interest in investigating the role of the growth hormone/insulin-like growth factor 1 axis in the initiation and progression of experimentally induced carcinomas has arisen due to several observations in the human population. First, subjects with Lar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e91f98e55a4242dfa6bd5239fec16f
https://europepmc.org/articles/PMC10140676/
https://europepmc.org/articles/PMC10140676/
Autor:
Christopher J Unterberger, Stephanie M McGregor, John J Kopchick, Steven M Swanson, Paul C Marker
Publikováno v:
Endocrinology
Female SV40 C3(1) T-antigen (C3(1)/TAg) transgenic mice develop mammary tumors that are molecularly similar to human basal-like breast cancers with 100% incidence at 16 weeks of age. To determine the requirement for growth hormone (GH) signaling in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e727843229d9c0a4e3dd97bc6fdadc7
https://doi.org/10.1210/endocr/bqac174
https://doi.org/10.1210/endocr/bqac174
Autor:
Christopher J Unterberger, Vilena I Maklakova, Michelle Lazar, Paige D Arneson, Sean J Mcilwain, Philippos K Tsourkas, Rong Hu, John J Kopchick, Steven M Swanson, Paul C Marker
Publikováno v:
Endocrinology
Previous studies investigating the effects of blocking the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis in prostate cancer found no effects of the growth hormone receptor (GHR) antagonist, pegvisomant, on the growth of grafted human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d86b0828272ed7c6f96a6269ca68c0f
https://europepmc.org/articles/PMC8995093/
https://europepmc.org/articles/PMC8995093/
Autor:
Olga Aprelikova, Christine C Tomlinson, Mark Hoenerhoff, Julie A Hixon, Scott K Durum, Ting-Hu Qiu, Siping He, Sandra Burkett, Zi-Yao Liu, Steven M Swanson, Jeffrey E Green
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155262 (2016)
Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer that is associated with a poor prognosis and for which no targeted therapies currently exist. In order to improve preclinical testing for TNBC that relies primarily on usi
Externí odkaz:
https://doaj.org/article/6cbcebf108f04e098e704c0eee495b7b
Autor:
Christian Erxleben, Steven M. Swanson, Jinhong Ren, A. Douglas Kinghorn, Yulin Ren, Joanna E. Burdette, Saverio Gentile, Wei Lun Chen, Michael E. Johnson
(+)-Strebloside, a cardiac glycoside isolated from the stem bark of Streblus asper collected in Vietnam, has shown some potential for further investigation as an antineoplastic agent. A mechanistic study using an in vitro assay and molecular docking
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4ebee22c7636c24a1b18b6974b6296d
Autor:
Yu-Dong Zhou, Jun Li, Lin Du, Fakhri Mahdi, Thuy P. Le, Wei-Lun Chen, Steven M. Swanson, Kounosuke Watabe, Dale G. Nagle
Publikováno v:
Marine Drugs, Vol 16, Iss 11, p 442 (2018)
Breast tumors reprogram their cellular metabolism, nutrient uptake, and utilization-associated biochemical processes. These processes become further transformed as genetically predisposed metastatic breast tumor cells colonize specific organs. Breast
Externí odkaz:
https://doaj.org/article/7f84aebf78ef426cb74e0e25fc4ec216