Zobrazeno 1 - 10
of 213
pro vyhledávání: '"Steven M, Lipkin"'
Autor:
Kun Xiang, Ergang Wang, John Mantyh, Gabrielle Rupprecht, Marcos Negrete, Golshid Sanati, Carolyn Hsu, Peggy Randon, Anders Dohlman, Kai Kretzschmar, Shree Bose, Nicholas Giroux, Shengli Ding, Lihua Wang, Jorge Prado Balcazar, Qiang Huang, Pasupathi Sundaramoorthy, Rui Xi, Shannon Jones McCall, Zhaohui Wang, Chongming Jiang, Yubin Kang, Scott Kopetz, Gregory E. Crawford, Steven M. Lipkin, Xiao‐Fan Wang, Hans Clevers, David Hsu, Xiling Shen
Publikováno v:
Advanced Science, Vol 11, Iss 16, Pp n/a-n/a (2024)
Abstract Patient‐Derived Organoids (PDO) and Xenografts (PDX) are the current gold standards for patient‐derived models of cancer (PDMC). Nevertheless, how patient tumor cells evolve in these models and the impact on drug response remains unclear
Externí odkaz:
https://doaj.org/article/1bb7ddf32e6044c991fd4618eff54a98
Autor:
Yurong Song, Travis D. Kerr, Chelsea Sanders, Lisheng Dai, Shaneen S. Baxter, Brandon Somerville, Ryan N. Baugher, Stephanie D. Mellott, Todd B. Young, Heidi E. Lawhorn, Teri M. Plona, Bingfang Xu, Lei Wei, Qiang Hu, Song Liu, Alan Hutson, Baktiar Karim, Sandra Burkett, Simone Difilippantonio, Ligia Pinto, Johannes Gebert, Matthias Kloor, Steven M. Lipkin, Shizuko Sei, Robert H. Shoemaker
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundGenome integrity is essential for the survival of an organism. DNA mismatch repair (MMR) genes (e.g., MLH1, MSH2, MSH6, and PMS2) play a critical role in the DNA damage response pathway for genome integrity maintenance. Germline mutations o
Externí odkaz:
https://doaj.org/article/0d2e5d6b71eb4b909e5643961c4ff61e
Autor:
Shizuko Sei, Aysel Ahadova, Derin B. Keskin, Lena Bohaumilitzky, Johannes Gebert, Magnus von Knebel Doeberitz, Steven M. Lipkin, Matthias Kloor
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Hereditary cancer syndromes (HCS) account for 5~10% of all cancer diagnosis. Lynch syndrome (LS) is one of the most common HCS, caused by germline mutations in the DNA mismatch repair (MMR) genes. Even with prospective cancer surveillance, LS is asso
Externí odkaz:
https://doaj.org/article/78a75d34ee574639a0ad6b8bee1fe57c
Room for improvement in capturing cancer family history in a gynecologic oncology outpatient setting
Autor:
Jenny Lin, Isabel Wolfe, Muhammad Danyal Ahsan, Hannah Krinsky, Andreas I. Lackner, Joe Pelt, Karen Bolouvi, Charlotte Gamble, Charlene Thomas, Paul J. Christos, Evelyn Cantillo, Kevin Holcomb, Eloise Chapman-Davis, Ravi Sharaf, Steven M. Lipkin, Stephanie V. Blank, Melissa K. Frey
Publikováno v:
Gynecologic Oncology Reports, Vol 40, Iss , Pp 100941- (2022)
The literature demonstrates that the quality of cancer family history (CFH) as currently collected in the outpatient setting is inadequate to assess disease risk. Prior to implementation of a web-based application for cancer family history collection
Externí odkaz:
https://doaj.org/article/7eedfd905d594e509e897fc8add3067b
Autor:
Kai‐Yuan Chen, Tara Srinivasan, Kuei‐Ling Tung, Julio M Belmonte, Lihua Wang, Preetish Kadur Lakshminarasimha Murthy, Jiahn Choi, Nikolai Rakhilin, Sarah King, Anastasia Kristine Varanko, Mavee Witherspoon, Nozomi Nishimura, James A Glazier, Steven M Lipkin, Pengcheng Bu, Xiling Shen
Publikováno v:
Molecular Systems Biology, Vol 13, Iss 4, Pp 1-16 (2017)
Abstract The intestinal epithelium is the fastest regenerative tissue in the body, fueled by fast‐cycling stem cells. The number and identity of these dividing and migrating stem cells are maintained by a mosaic pattern at the base of the crypt. Ho
Externí odkaz:
https://doaj.org/article/1b673af1fdcb4bcdaa53740941263cec
Autor:
A. Rouf Banday, Megan L. Stanifer, Oscar Florez-Vargas, Olusegun O. Onabajo, Brenen W. Papenberg, Muhammad A. Zahoor, Lisa Mirabello, Timothy J. Ring, Chia-Han Lee, Paul S. Albert, Evangelos Andreakos, Evgeny Arons, Greg Barsh, Leslie G. Biesecker, David L. Boyle, Mark S. Brahier, Andrea Burnett-Hartman, Mary Carrington, Euijin Chang, Pyoeng Gyun Choe, Rex L. Chisholm, Leandro M. Colli, Clifton L. Dalgard, Carolynn M. Dude, Jeff Edberg, Nathan Erdmann, Heather S. Feigelson, Benedito A. Fonseca, Gary S. Firestein, Adam J. Gehring, Cuncai Guo, Michelle Ho, Steven Holland, Amy A. Hutchinson, Hogune Im, Les’Shon Irby, Michael G. Ison, Naima T. Joseph, Hong Bin Kim, Robert J. Kreitman, Bruce R. Korf, Steven M. Lipkin, Siham M. Mahgoub, Iman Mohammed, Guilherme L. Paschoalini, Jennifer A. Pacheco, Michael J. Peluso, Daniel J. Rader, David T. Redden, Marylyn D. Ritchie, Brooke Rosenblum, M. Elizabeth Ross, Hanaisa P. Sant Anna, Sharon A. Savage, Sudha Sharma, Eleni Siouti, Alicia K. Smith, Vasiliki Triantafyllia, Joselin M. Vargas, Jose D. Vargas, Anurag Verma, Vibha Vij, Duane R. Wesemann, Meredith Yeager, Xu Yu, Yu Zhang, Steeve Boulant, Stephen J. Chanock, Jordan J. Feld, Ludmila Prokunina-Olsson
Publikováno v:
Nature Genetics. 54:1103-1116
The chr12q24.13 locus encoding OAS1–OAS3 antiviral proteins has been associated with coronavirus disease 2019 (COVID-19) susceptibility. Here, we report genetic, functional and clinical insights into this locus in relation to COVID-19 severity. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37dd9b81fcf718f9727fc32dc0c8e6d8
https://doi.org/10.1038/s41588-022-01113-z
https://doi.org/10.1038/s41588-022-01113-z
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Immunoediting is an important concept in oncology, delineating the mechanisms through which tumors are selected for resistance to immune-mediated elimination. The recent emergence of immunotherapies, such as checkpoint inhibitors, as pillars of cance
Externí odkaz:
https://doaj.org/article/16a55469b79b41a7be0f4792ace89995
Autor:
Steven M. Lipkin, Daniel W. Rosenberg, Eva Szabo, Luz Maria Rodriguez, Rachel Gonzalez, Jinah Chung, Vanessa Wong, Myra Arcilla, Zhiliang Huang, Asmita Bhattacharya, Chris Tucker, Allen Mo, Wen-Pin Chen, Richard Benya, Robert Carroll, Jason A. Zell, Timothy R. Morgan, Frank L. Meyskens, Daniel L. Gillen
Supplemental Methods and Materials. ACF Phospho-ERK and ERK Level Quantification.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba8d026c6b15d98e566c3c2512cb390a
https://doi.org/10.1158/1940-6207.22526415.v1
https://doi.org/10.1158/1940-6207.22526415.v1
Autor:
Steven M. Lipkin, Daniel W. Rosenberg, Eva Szabo, Luz Maria Rodriguez, Rachel Gonzalez, Jinah Chung, Vanessa Wong, Myra Arcilla, Zhiliang Huang, Asmita Bhattacharya, Chris Tucker, Allen Mo, Wen-Pin Chen, Richard Benya, Robert Carroll, Jason A. Zell, Timothy R. Morgan, Frank L. Meyskens, Daniel L. Gillen
Colorectal cancer progresses through multiple distinct stages that are potentially amenable to chemopreventative intervention. Epidermal growth factor receptor (EGFR) inhibitors are efficacious in advanced tumors including colorectal cancer. There is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39e34cc770ee56ede8273e0111e64c82
https://doi.org/10.1158/1940-6207.c.6545085.v1
https://doi.org/10.1158/1940-6207.c.6545085.v1
Supplementary Figure S4 - PDF file 23K, Fig S4. DFMO Normal Human Colon Tissue. Normal human colon tissues were treated with DFMO(300nM) for 4 days. After treatment metabolites were extracted and analyzed by LC MS/MS. S-adenosine methionine(SAM) down
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c19ec5a6ee2f2ed24847a99949e8cd0
https://doi.org/10.1158/2159-8290.22530299
https://doi.org/10.1158/2159-8290.22530299