Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Steven M, LeVine"'
Autor:
Steven M. LeVine
Publikováno v:
Cells, Vol 13, Iss 8, p 689 (2024)
Elevated levels of iron occur in both cortical and subcortical regions of the CNS in patients with Alzheimer’s disease. This accumulation is present early in the disease process as well as in more advanced stages. The factors potentially accounting
Externí odkaz:
https://doaj.org/article/42e0d6914452411c954efa1580d94e91
Autor:
Steven M. LeVine
Publikováno v:
Cells, Vol 12, Iss 22, p 2641 (2023)
The recently presented Azalea Hypothesis for Alzheimer’s disease asserts that iron becomes sequestered, leading to a functional iron deficiency that contributes to neurodegeneration. Iron sequestration can occur by iron being bound to protein aggre
Externí odkaz:
https://doaj.org/article/2e3a3fbf3f1d4c58889d6eef4b71cf56
Autor:
Darren L. Sultan, Mona Clappier, John Perrotti, Sabrina Siddiqui, James P. Bradley, Steven M. Levine, Alan Matarasso, Edward M. Reece, Armen K. Kasabian, Neil Tanna
Publikováno v:
Surgery in Practice and Science, Vol 10, Iss , Pp 100082- (2022)
Background: The geographic proclivities of plastic surgery trainees have important ramifications for the field of plastic surgery. Methods: Names of American Society of Plastic Surgeons (ASPS) members who were board-certified in 2000, 2005, 2010, 201
Externí odkaz:
https://doaj.org/article/da1d9256a3194690a080b4c9e0cd4cf2
Publikováno v:
Brain Sciences, Vol 13, Iss 3, p 511 (2023)
The involvement of iron in the pathogenesis of Alzheimer’s disease (AD) may be multifaceted. Besides potentially inducing oxidative damage, the bioavailability of iron may be limited within the central nervous system, creating a functionally iron-d
Externí odkaz:
https://doaj.org/article/edcaafbe92e3431c83f9d69ce487d8bd
Autor:
Steven M. LeVine, Sheila Tsau
Publikováno v:
Frontiers in Pediatrics, Vol 9 (2022)
Krabbe disease is a lysosomal storage disease that is caused by a deficiency in galactosylceramidase. Infantile onset disease is the most common presentation, which includes progressive neurological deterioration with corresponding demyelination, dev
Externí odkaz:
https://doaj.org/article/753e1e3bfdf04fc6931f260b58849a34
Publikováno v:
ASN Neuro, Vol 13 (2021)
Although all cells contain iron, most histochemical methods fail to reveal the presence of iron within many cells of the central nervous system (CNS), particularly neurons. Previously, a sensitive method was developed that limited the extraction of i
Externí odkaz:
https://doaj.org/article/532a674fcd5a4e0faf33a5476de9eb01
Autor:
Cyrille C. Thinnes, Raphaelle Lesage, Marlène Mengoni, Cécile F. Rousseau, Anne Thorez, Bernard Staumont, Martha De Cunha Maluf-Burgman, Liesbet Geris, Thierry Marchal, Alexandre Serigado, Emmanuelle Voisin, Steven M. Levine
The Avicenna Public & Patient Involvement (PPI) task force present their first position paper with focus on assessing the status quo and proposing an action plan for establishing PPI within in silico medicine. While PPI has gained significant momentu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4382afad29e63b4c16d2262c36e26064
Publikováno v:
Neural Regeneration Research, Vol 12, Iss 8, Pp 1262-1267 (2017)
Unlike relapsing remitting multiple sclerosis, there are very few therapeutic options for patients with progressive forms of multiple sclerosis. While immune mechanisms are key participants in the pathogenesis of relapsing remitting multiple sclerosi
Externí odkaz:
https://doaj.org/article/c79cba892a714d7eb2d46c540cde3ca6
Autor:
Scott Balsitis, Volodymyr Gali, Pamela J Mason, Susan Chaniewski, Steven M Levine, Michael J Wichroski, Michael Feulner, Yunling Song, Karen Granaldi, James K Loy, Chris M Thompson, Jacob A Lesniak, Catherine Brockus, Narendra Kishnani, Stephan Menne, Mark I Cockett, Renuka Iyer, Stephen W Mason, Daniel J Tenney
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0190058 (2018)
Immune clearance of Hepatitis B virus (HBV) is characterized by broad and robust antiviral T cell responses, while virus-specific T cells in chronic hepatitis B (CHB) are rare and exhibit immune exhaustion that includes programmed-death-1 (PD-1) expr
Externí odkaz:
https://doaj.org/article/86a83d2c3bb74090986d3dcb2cb37f05
Autor:
Srividya Sundararaman, Alexey Y. Karulin, Tameem Ansari, Nadine BenHamouda, Judith Gottwein, Sreenivas Laxmanan, Steven M. Levine, John T. Loffredo, Stephanie McArdle, Christine Neudoerfl, Diana Roen, Karina Silina, Mackenzie Welch, Paul V. Lehmann
Publikováno v:
Cells, Vol 4, Iss 1, Pp 21-39 (2015)
The primary goal of immune monitoring with ELISPOT is to measure the number of T cells, specific for any antigen, accurately and reproducibly between different laboratories. In ELISPOT assays, antigen-specific T cells secrete cytokines, forming spots
Externí odkaz:
https://doaj.org/article/4b8b577842b84291b39e2adf1401c336