Výsledky vyhledávání - "Steven L. Wechsler"

Akademický článek

Inclusion of CD80 in HSV targets the recombinant virus to PD-L1 on DCs and allows productive infection and robust immune responses.

Autor: Kevin R Mott, Sariah J Allen, Mandana Zandian, Omid Akbari, Pedram Hamrah, Hadi Maazi, Steven L Wechsler, Arlene H Sharpe, Gordon J Freeman, Homayon Ghiasi

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e87617 (2014)

CD80 plays a critical role in stimulation of T cells and subsequent control of infection. To investigate the effect of CD80 on HSV-1 infection, we constructed a recombinant HSV-1 virus that expresses two copies of the CD80 gene in place of the latenc

Externí odkaz: https://doaj.org/article/5ed1cbe20605481688fe9d58277dc9b0

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Akademický článek

CD8α dendritic cells drive establishment of HSV-1 latency.

Autor: Kevin R Mott, Sariah J Allen, Mandana Zandian, Bindu Konda, Behrooz G Sharifi, Clinton Jones, Steven L Wechsler, Terrence Town, Homayon Ghiasi

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e93444 (2014)

It is generally accepted that CD8 T cells play the key role to maintain HSV-1 latency in trigeminal ganglia of ocularly infected mice. Yet, comparably little is known about the role of innate immunity in establishment of viral latency. In the current

Externí odkaz: https://doaj.org/article/0752d9b119dc447b83ae505c1607c9d3

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The Herpes Simplex Virus Latency-Associated Transcript Gene Is Associated with a Broader Repertoire of Virus-Specific Exhausted CD8 + T Cells Retained within the Trigeminal Ganglia of Latently Infected HLA Transgenic Rabbits

Autor: Ruchi Srivastava, Nicolas N. Ong, Anthony B. Nesburn, Lbachir BenMohamed, Sravya Chilukuri, Xavier Dervillez, Arif A. Khan, Rasha E. Afifi, Aziz Alami Chentoufi, Nelson Osorio, Roger Geertsema, Nora Shukr, Yasmin Fazli, Steven L. Wechsler

Publikováno v: Journal of Virology. 90:3913-3928

Persistent pathogens, such as herpes simplex virus 1 (HSV-1), have evolved a variety of immune evasion strategies to avoid being detected and destroyed by the host's immune system. A dynamic cross talk appears to occur between the HSV-1 latency-assoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44932e220ac5cc163b68c9c29d642b3c
https://doi.org/10.1128/jvi.02450-15

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Prior Corneal Scarification and Injection of Immune Serum are Not Required Before Ocular HSV-1 Infection for UV-B-Induced Virus Reactivation and Recurrent Herpetic Corneal Disease in Latently Infected Mice

Autor: Lbachir BenMohamed, Nelson Osorio, Jairo M. Garcia, John J. Krochmal, Jennifer Simpson, Ruchi Srivastava, Lei Huang, Steven L. Wechsler, Arif A. Khan

Publikováno v: Current eye research, vol 41, iss 6

PurposeBlinding ocular herpetic disease in humans is due to spontaneous reactivation of herpes simplex virus type 1 (HSV-1) from latency, rather than to primary acute infection. Mice latently infected with HSV-1 undergo little or no in vivo spontaneo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::832ef457e143e2e1f4f9bbe5d6b97656
https://doi.org/10.3109/02713683.2015.1061024

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Therapeutic Immunization with a Mixture of Herpes Simplex Virus 1 Glycoprotein D-Derived 'Asymptomatic' Human CD8 + T-Cell Epitopes Decreases Spontaneous Ocular Shedding in Latently Infected HLA Transgenic Rabbits: Association with Low Frequency of Local PD-1 + TIM-3 + CD8 + Exhausted T Cells

Autor: Nhi Thi Uyen Thai, Mina Kalantari, Nelson Osorio, Gargi Dasgupta, Ruchi Srivastava, Aziz Alami Chentoufi, Arif A. Khan, Steven L. Wechsler, Anthony B. Nesburn, Lbachir BenMohamed, Roger Geertsema

Publikováno v: Journal of Virology. 89:6619-6632

Most blinding ocular herpetic disease is due to reactivation of herpes simplex virus 1 (HSV-1) from latency rather than to primary acute infection. No herpes simplex vaccine is currently available for use in humans. In this study, we used the HLA-A*0

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0074e1b41ee40680e4b17e37f4a92095
https://doi.org/10.1128/jvi.00788-15

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Decreased reactivation of a herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) mutant using the in vivo mouse UV-B model of induced reactivation

Autor: Nelson Osorio, Steven L. Wechsler, Arif A. Khan, Jennifer Simpson, Ruchi Srivastava, Lbachir BenMohamed

Publikováno v: BenMohamed, Lbachir; Osorio, Nelson; Srivastava, Ruchi; Khan, Arif A; Simpson, Jennifer L; & Wechsler, Steven L. (2015). Decreased reactivation of a herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) mutant using the in vivo mouse UV-B model of induced reactivation. Journal of NeuroVirology, 21(5), 508-517. doi: 10.1007/s13365-015-0348-9. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/2sr083j6

Blinding ocular herpetic disease in humans is due to herpes simplex virus type 1 (HSV-1) reactivations from latency, rather than to primary acute infection. The cellular and molecular immune mechanisms that control the HSV-1 latency-reactivation cycl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::844b133f9e059aac04ccc020fc690fd7
https://doi.org/10.1007/s13365-015-0348-9

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A herpes simplex virus type 1 mutant disrupted for microRNA H2 with increased neurovirulence and rate of reactivation

Autor: Steven L. Wechsler, Nelson Osorio, Xianzhi Jiang, Lbachir BenMohamed, Donald J. Brown, Chinhui Hsiang, Lily Li, Lucas Chan

Publikováno v: Jiang, Xianzhi; Brown, Don; Osorio, Nelson; Hsiang, Chinhui; Li, Lily; Chan, Lucas; et al.(2015). A herpes simplex virus type 1 mutant disrupted for microRNA H2 with increased neurovirulence and rate of reactivation. Journal of NeuroVirology, 21(2), 199-209. doi: 10.1007/s13365-015-0319-1. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/53v0g8cs

The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) encodes several microRNAs. One of these, miR-H2, overlaps and is antisense to the ICP0 gene and appears to decrease expression of the ICP0 protein. To determine if miR-H2 pla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73f1aa0543d5bbea78f84d7a71755791
https://doi.org/10.1007/s13365-015-0319-1

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