A Tribute to Professor Steven L. Wechsler (1948-2016): The Man and the Scientist

Autor: Anthony B. Nesburn, Lbachir BenMohamed

Publikováno v: Current eye research, vol 42, iss 1

Professor Steven L. Wechsler, a world-renowned eye researcher and virologist, passed away unexpectedly on June 12, 2016 at the age of 68. Many scientists came to know Professor Wechsler as a gifted researcher in the field of ocular Herpes Simplex Vir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::137649b949d7af622e11a482c18ddaf8
https://escholarship.org/uc/item/2d7271bg

CD8α dendritic cells drive establishment of HSV-1 latency.

Autor: Kevin R Mott, Sariah J Allen, Mandana Zandian, Bindu Konda, Behrooz G Sharifi, Clinton Jones, Steven L Wechsler, Terrence Town, Homayon Ghiasi

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e93444 (2014)

It is generally accepted that CD8 T cells play the key role to maintain HSV-1 latency in trigeminal ganglia of ocularly infected mice. Yet, comparably little is known about the role of innate immunity in establishment of viral latency. In the current

Externí odkaz: https://doaj.org/article/0752d9b119dc447b83ae505c1607c9d3

Prior Corneal Scarification and Injection of Immune Serum are Not Required Before Ocular HSV-1 Infection for UV-B-Induced Virus Reactivation and Recurrent Herpetic Corneal Disease in Latently Infected Mice

Autor: Lbachir BenMohamed, Nelson Osorio, Jairo M. Garcia, John J. Krochmal, Jennifer Simpson, Ruchi Srivastava, Lei Huang, Steven L. Wechsler, Arif A. Khan

Publikováno v: Current eye research, vol 41, iss 6

PurposeBlinding ocular herpetic disease in humans is due to spontaneous reactivation of herpes simplex virus type 1 (HSV-1) from latency, rather than to primary acute infection. Mice latently infected with HSV-1 undergo little or no in vivo spontaneo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::832ef457e143e2e1f4f9bbe5d6b97656
https://doi.org/10.3109/02713683.2015.1061024

Decreased reactivation of a herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) mutant using the in vivo mouse UV-B model of induced reactivation

Autor: Nelson Osorio, Steven L. Wechsler, Arif A. Khan, Jennifer Simpson, Ruchi Srivastava, Lbachir BenMohamed

Publikováno v: BenMohamed, Lbachir; Osorio, Nelson; Srivastava, Ruchi; Khan, Arif A; Simpson, Jennifer L; & Wechsler, Steven L. (2015). Decreased reactivation of a herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) mutant using the in vivo mouse UV-B model of induced reactivation. Journal of NeuroVirology, 21(5), 508-517. doi: 10.1007/s13365-015-0348-9. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/2sr083j6

Blinding ocular herpetic disease in humans is due to herpes simplex virus type 1 (HSV-1) reactivations from latency, rather than to primary acute infection. The cellular and molecular immune mechanisms that control the HSV-1 latency-reactivation cycl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::844b133f9e059aac04ccc020fc690fd7
https://doi.org/10.1007/s13365-015-0348-9

A Herpes Simplex Virus Type 1 Human Asymptomatic CD8+ T-Cell Epitopes-Based Vaccine Protects Against Ocular Herpes in a 'Humanized' HLA Transgenic Rabbit Model

Autor: Jiawei Huang, Anthony B. Nesburn, Lbachir BenMohamed, Arif A. Khan, Steven L. Wechsler, Ruchi Srivastava

Publikováno v: Investigative ophthalmologyvisual science. 56(6)

Immunology and Microbiology A Herpes Simplex Virus Type 1 Human Asymptomatic CD8 þ T-Cell Epitopes-Based Vaccine Protects Against Ocular Herpes in a ‘‘Humanized’’ HLA Transgenic Rabbit Model Ruchi Srivastava, 1 Arif A. Khan, 1 Jiawei Huang,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52a435e7965709170d4d7151b43d1250
https://pubmed.ncbi.nlm.nih.gov/26098469