Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Steven L. Ponicsan"'
Autor:
Natalie G. Ahn, William M. Old, Steven L. Ponicsan, James A. Goodrich, Jennifer F. Kugel, Stephane Houel
Publikováno v:
Journal of Molecular Biology. 425:3625-3638
The B2 family of short interspersed elements is transcribed into non-coding RNA by RNA polymerase III. The ~180-nt B2 RNA has been shown to potently repress mRNA transcription by binding tightly to RNA polymerase II (Pol II) and assembling with it in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f64479f2e0d741eb9fec36b712fae83d
https://doi.org/10.1016/j.jmb.2013.01.035
https://doi.org/10.1016/j.jmb.2013.01.035
Autor:
Bradley D. Gelfand, Jayakrishna Ambati, Mark E. Kleinman, Sasha Bogdanovich, Steven L. Ponicsan, Judit Z. Baffi, James A. Goodrich, Yoshio Hirano, David R. Hinton, Balamurali K. Ambati, Jennifer F. Kugel, Valeria Tarallo, Younghee Kim, Vince A. Chiodo, Benjamin J. Fowler, William W. Hauswirth, Sami Dridi
Publikováno v:
Proceedings of the National Academy of Sciences. 109:13781-13786
Deficient expression of the RNase III DICER1, which leads to the accumulation of cytotoxic Alu RNA, has been implicated in degeneration of the retinal pigmented epithelium (RPE) in geographic atrophy (GA), a late stage of age-related macular degenera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ecae0f8dcec0a5aade472cdd51183c
https://doi.org/10.1073/pnas.1206494109
https://doi.org/10.1073/pnas.1206494109
Autor:
Jassir Witta, Smita Misra, David R. Hinton, Balamurali K. Ambati, Judit Z. Baffi, Gautam Chaudhuri, Mark M.W. Chong, Dan R. Littman, Bradley D. Gelfand, Sami Dridi, Yoshio Hirano, Alexander D Blandford, Jae-Wook Yoo, James A. Goodrich, Jan Provis, Jayakrishna Ambati, William W. Hauswirth, Valeria Tarallo, Romulo Albuquerque, Hiroki Kaneko, Frank W. Buaas, Vince A. Chiodo, Joshua L. Dunaief, Won Gil Cho, Katalin Karikó, Nikki L. Justice, Charles M. Rudin, Elaine Fuchs, Michele C. Madigan, Ying Qing Song, Hans E. Grossniklaus, Mark E. Kleinman, Ann H. Milam, Steven L. Ponicsan, Patrick Provost, Dong Ki Lee, Jennifer F. Kugel, Benjamin J. Fowler, Robert E. Braun, Qing-qing Zhang, Majda Hadziahmetovic, Sasha Bogdanovich
Publikováno v:
Nature
Geographic atrophy (GA), an untreatable advanced form of age-related macular degeneration, results from retinal pigmented epithelium (RPE) cell degeneration. Here we show that the microRNA (miRNA)-processing enzyme DICER1 is reduced in the RPE of hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40d5c6c23992a2da76ef7086a2928b76
https://doi.org/10.1038/nature09830
https://doi.org/10.1038/nature09830
Publikováno v:
Current Opinion in Genetics & Development. 20:149-155
Mammalian short interspersed elements (SINEs) are abundant retrotransposons that have long been considered junk DNA; however, RNAs transcribed from mouse B2 and human Alu SINEs have recently been found to control mRNA production at multiple levels. U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0570aebae5fe018fd65bbdd6a33de0d6
https://doi.org/10.1016/j.gde.2010.01.004
https://doi.org/10.1016/j.gde.2010.01.004
Publikováno v:
Non-Coding RNA
Volume 1
Issue 1
Pages 4-16
Volume 1
Issue 1
Pages 4-16
B2 RNA is a mouse non-coding RNA that binds directly to RNA polymerase II (Pol II) and represses transcription by disrupting critical interactions between the polymerase and promoter DNA. How the structural regions within B2 RNA work together to medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48b9bd12985eaeccc6b1e082bc68db8c
DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88
Autor:
Benjamin J. Fowler, Yuichiro Ogura, Nagaraj Kerur, Judit Z. Baffi, Sami Dridi, Mark E. Kleinman, Patrick Provost, Dong Ki Lee, Vince A. Chiodo, Sasha Bogdanovich, Jennifer F. Kugel, Steven L. Ponicsan, William W. Hauswirth, James A. Goodrich, Romulo Albuquerque, Balamurali K. Ambati, Michael P. Murphy, Bradley D. Gelfand, Joshua L. Dunaief, Won Gil Cho, Gabriel Núñez, Hiroki Kaneko, David R. Hinton, Gautam Chaudhuri, Yoshio Hirano, Jayakrishna Ambati, Valeria Tarallo, Younghee Kim, Jae Wook Yoo
Publikováno v:
Cell. (4):847-859
SummaryAlu RNA accumulation due to DICER1 deficiency in the retinal pigmented epithelium (RPE) is implicated in geographic atrophy (GA), an advanced form of age-related macular degeneration that causes blindness in millions of individuals. The mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7562c580258bcea3fec1b48ef9c6c630