Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Steven L. Jinks"'
Autor:
Christophe Morisseau, Bora Inceoglu, Kara Schmelzer, Hsing-Ju Tsai, Steven L. Jinks, Christine M. Hegedus, Bruce D. Hammock
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 12, Pp 3481-3490 (2010)
Beneficial physiological effects of long-chain n-3 polyunsaturated fatty acids are widely accepted but the mechanism(s) by which these fatty acids act remains unclear. Herein, we report the presence, distribution, and regulation of the levels of n-3
Externí odkaz:
https://doaj.org/article/0cc550e168cb4fa5b115950cc1c7a34e
Publikováno v:
NeuroReport. 22:655-659
General anesthetic mechanisms are poorly understood. Anesthetic immobilizing effects occur in the spinal ventral horn. However, a detailed analysis of anesthetic effects on ventral motor networks is lacking. We delivered isoflurane, desflurane, or pr
Autor:
Tristan E. Rose, Christine Hegedus, Arzu Ulu, Bruce D. Hammock, Bora Inceoglu, Robert J Brosnan, Steven L. Jinks, Karen Wagner, Christophe Morisseau, Nils Helge Schebb
Publikováno v:
Proceedings of the National Academy of Sciences. 108:5093-5097
Pain is a major health concern even though numerous analgesic agents are available. Side effects and lack of wide-spectrum efficacy of current drugs justify efforts to better understand pain mechanisms. Stabilization of natural epoxy-fatty acids (EFA
Autor:
Bruce D. Hammock, Bora Inceoglu, Christine Hegedus, Hsing Ju Tsai, Christophe Morisseau, Steven L. Jinks, Kara R. Schmelzer
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 12, Pp 3481-3490 (2010)
Beneficial physiological effects of long-chain n-3 polyunsaturated fatty acids are widely accepted but the mechanism(s) by which these fatty acids act remains unclear. Herein, we report the presence, distribution, and regulation of the levels of n-3
Publikováno v:
NeuroReport. 21:303-308
Itch is thought to be signaled by pruritogen-responsive neurons in the superficial spinal dorsal horn. Many neurons here express the substance P NK-1 receptor. We investigated whether neurotoxic destruction of spinal NK-1-expressing neurons affected
Publikováno v:
Anesthesia & Analgesia. 109:1111-1116
Background Nitrous oxide (N(2)O) acts on supraspinal noradrenergic neurons to produce analgesia, but it is unclear if analgesia contributes to N(2)O's immobilizing effects. We tested the hypothesis that N(2)O minimum alveolar anesthetic concentration
Publikováno v:
Anesthesia & Analgesia. 109:641-647
The mechanism and site of action within the spinal cord by which volatile anesthetics produce immobility are not well understood. Little work has been done directly comparing anesthetic effects on neurons with specific functional characteristics that
Publikováno v:
Anesthesiology. 108:1016-1024
Volatile anesthetics act primarily in the spinal cord to abolish movement in response to noxious stimulation.1–3 However, anesthetic action does not seem to be uniform across different classes of neurons residing in different anatomical locations o
Publikováno v:
Life Sciences. 79:2311-2319
Soluble epoxide hydrolases catalyze the hydrolysis of epoxides in acyclic systems. In man this enzyme is the product of a single copy gene (EPXH-2) present on chromosome 8. The human sEH is of interest due to emerging roles of its endogenous substrat
Autor:
Bora Inceoglu, Bruce D. Hammock, Kara R. Schmelzer, Lukáš Kubala, In Hae Kim, Steven L. Jinks, Jason P. Eiserich
Publikováno v:
Proceedings of the National Academy of Sciences. 103:13646-13651
Combination therapies have long been used to treat inflammation while reducing side effects. The present study was designed to evaluate the therapeutic potential of combination treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) and previous