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Autor:
M. Robert Leanna, Eric J. Stoner, Maureen A. McLaughlin, Steven L. Condon, Steven A. King, Francis A. J. Kerdesky, Steven J. Wittenberger, Matthew J. Peterson, Michael Rasmussen, Daniel J. Plata
Publikováno v:
Tetrahedron. 60:10171-10180
A practical and efficient synthesis of ketolide antibiotic cethromycin (ABT-773) (1) is described. An effective protection strategy allows high yielding, regioselective C6-O-alkylation and subsequent stereoselective modification of the erythromycin n