Zobrazeno 1 - 10
of 220
pro vyhledávání: '"Steven L. Brody"'
Autor:
Maritza Puray-Chavez, Jenna E. Eschbach, Ming Xia, Kyle M. LaPak, Qianzi Zhou, Ria Jasuja, Jiehong Pan, Jian Xu, Zixiang Zhou, Shawn Mohammed, Qibo Wang, Dana Q. Lawson, Sanja Djokic, Gaopeng Hou, Siyuan Ding, Steven L. Brody, Michael B. Major, Dennis Goldfarb, Sebla B. Kutluay
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Host factors that define the cellular tropism of SARS-CoV-2 beyond the cognate ACE2 receptor are poorly defined. Here we report that SARS-CoV-2 replication is restricted at a post-entry step in a number of ACE2-positive airway-derived cell l
Externí odkaz:
https://doaj.org/article/941914b9381f4ed29c36d7cbcb886821
Autor:
Dheeraj Rayamajhi, Mert Ege, Kirill Ukhanov, Christa Ringers, Yiliu Zhang, Inyoung Jung, Percival P. D’Gama, Summer Shijia Li, Mehmet Ilyas Cosacak, Caghan Kizil, Hae-Chul Park, Emre Yaksi, Jeffrey R. Martens, Steven L. Brody, Nathalie Jurisch-Yaksi, Sudipto Roy
Publikováno v:
PLoS Biology, Vol 22, Iss 1 (2024)
Externí odkaz:
https://doaj.org/article/3880eb8ee583477ebeab8c0dc4372e38
Autor:
Amjad Horani, Deepesh Kumar Gupta, Jian Xu, Huihui Xu, Lis del Carmen Puga-Molina, Celia M. Santi, Sruthi Ramagiri, Steven K. Brennan, Jiehong Pan, Jeffrey R. Koenitzer, Tao Huang, Rachael M. Hyland, Sean P. Gunsten, Shin-Cheng Tzeng, Jennifer M. Strahle, Pleasantine Mill, Moe R. Mahjoub, Susan K. Dutcher, Steven L. Brody
Publikováno v:
JCI Insight, Vol 8, Iss 11 (2023)
DNAAF5 is a dynein motor assembly factor associated with the autosomal heterogenic recessive condition of motile cilia, primary ciliary dyskinesia (PCD). The effects of allele heterozygosity on motile cilia function are unknown. We used CRISPR-Cas9 g
Externí odkaz:
https://doaj.org/article/a8958a20c7784cb38752182a624f9384
Publikováno v:
mBio, Vol 14, Iss 3 (2023)
ABSTRACT Infection of individual cells by multiple virions plays critical roles in the replication and spread of many viruses, but mechanisms that control cellular coinfection during multicycle viral growth remain unclear. Here, we investigate virus-
Externí odkaz:
https://doaj.org/article/de40c05584604bd6ba1b95e6adcdef3f
Autor:
Amjad Horani, Steven L. Brody
Publikováno v:
ERJ Open Research, Vol 9, Iss 2 (2023)
Externí odkaz:
https://doaj.org/article/9631dfb913ad4c22ba3764cb50749f50
Autor:
Piyumi Wijesekara, Prakarsh Yadav, Lydia A. Perkins, Donna B. Stolz, Jonathan M. Franks, Simon C. Watkins, Emily Reinoso Jacome, Steven L. Brody, Amjad Horani, Jian Xu, Amir Barati Farimani, Xi Ren
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104730- (2022)
Summary: Motile cilia project from the airway apical surface and directly interface with inhaled external environment. Owing to cilia’s nanoscale dimension and high beating frequency, quantitative assessment of their motility remains a sophisticate
Externí odkaz:
https://doaj.org/article/b3f3affa0c6243d3b054392166f5291d
Autor:
Maritza Puray-Chavez, Nakyung Lee, Kasyap Tenneti, Yiqing Wang, Hung R. Vuong, Yating Liu, Amjad Horani, Tao Huang, Sean P. Gunsten, James B. Case, Wei Yang, Michael S. Diamond, Steven L. Brody, Joseph Dougherty, Sebla B. Kutluay
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes a number of strategies to modulate viral and host mRNA translation. Here, we used ribosome profiling in SARS-CoV-2-infected model cell lines and primary airway cells grown
Externí odkaz:
https://doaj.org/article/676d5a8350f546c5baeaa34cae4b2506
Autor:
Juhee Son, Shimeng Huang, Qiru Zeng, Traci L. Bricker, James Brett Case, Jinzhu Zhou, Ruochen Zang, Zhuoming Liu, Xinjian Chang, Tamarand L. Darling, Jian Xu, Houda H. Harastani, Lu Chen, Maria Florencia Gomez Castro, Yongxiang Zhao, Hinissan P. Kohio, Gaopeng Hou, Baochao Fan, Beibei Niu, Rongli Guo, Paul W. Rothlauf, Adam L. Bailey, Xin Wang, Pei-Yong Shi, Elisabeth D. Martinez, Steven L. Brody, Sean P. J. Whelan, Michael S. Diamond, Adrianus C. M. Boon, Bin Li, Siyuan Ding
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT Pathogenic coronaviruses are a major threat to global public health. Here, using a recombinant reporter virus-based compound screening approach, we identified small-molecule inhibitors that potently block the replication of severe acute resp
Externí odkaz:
https://doaj.org/article/9c29ed90b7cd4b61b729c1e9c1dba354
Autor:
Leandro Castaneyra-Ruiz, James P. McAllister, Diego M. Morales, Steven L. Brody, Albert M. Isaacs, David D. Limbrick
Publikováno v:
Fluids and Barriers of the CNS, Vol 17, Iss 1, Pp 1-11 (2020)
Abstract Background Severe intraventricular hemorrhage (IVH) is one of the most devastating neurological complications in preterm infants, with the majority suffering long-term neurological morbidity and up to 50% developing post-hemorrhagic hydrocep
Externí odkaz:
https://doaj.org/article/d1c22923e8164dfca1f0f2725105203b
Autor:
Maritza Puray-Chavez, Kyle M. LaPak, Travis P. Schrank, Jennifer L. Elliott, Dhaval P. Bhatt, Megan J. Agajanian, Ria Jasuja, Dana Q. Lawson, Keanu Davis, Paul W. Rothlauf, Zhuoming Liu, Heejoon Jo, Nakyung Lee, Kasyap Tenneti, Jenna E. Eschbach, Christian Shema Mugisha, Emily M. Cousins, Erica W. Cloer, Hung R. Vuong, Laura A. VanBlargan, Adam L. Bailey, Pavlo Gilchuk, James E. Crowe, Jr., Michael S. Diamond, D. Neil Hayes, Sean P.J. Whelan, Amjad Horani, Steven L. Brody, Dennis Goldfarb, M. Ben Major, Sebla B. Kutluay
Publikováno v:
Cell Reports, Vol 36, Iss 2, Pp 109364- (2021)
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) variants govern transmissibility, responsiveness to vaccination, and disease severity. In a screen for new models of SARS-CoV-2 infection, we identify human H522 lung ade
Externí odkaz:
https://doaj.org/article/fd7ca3003b0d4b6e81dd2ed8d532da99