Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Steven L Smock"'
Autor:
Jianwu Bai, Steven L Smock, George R Jackson, Kenzie D MacIsaac, Yongsheng Huang, Courtney Mankus, Jonathan Oldach, Brian Roberts, Yu-Lu Ma, Joel A Klappenbach, Michael A Crackower, Stephen E Alves, Patrick J Hayden
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0118286 (2015)
Human airway epithelial cells are the principal target of human rhinovirus (HRV), a common cold pathogen that triggers the majority of asthma exacerbations. The objectives of this study were 1) to evaluate an in vitro air liquid interface cultured hu
Externí odkaz:
https://doaj.org/article/63cf64f8100649a6b70ec6bbe21137ad
Autor:
Stephen E. Alves, Michael A. Crackower, Philip R Cooper, Alan B. Northrup, Dennis M. Zaller, Erich E Sirkowski, Gretchen A. Baltus, Cynthia J. Koziol-White, Steven L. Smock, Blanca E. Himes, Reynold A. Panettieri, Yanlin Jia
Publikováno v:
British Journal of Pharmacology. 173:3080-3087
Background and purpose Asthma manifests as a heterogeneous syndrome characterized by airway obstruction, inflammation and hyper-reactivity (AHR). Spleen tyrosine kinase (Syk) mediates allergen-induced mast cell degranulation, a central component of a
Autor:
S.N. Popoff, John A. Arnott, Fayez F. Safadi, X. Zhang, Steven L. Smock, W. G. Delong, Saqib Rehman, Thomas A. Owen, Archana Sanjay
Publikováno v:
Bone. 42:871-885
Connective tissue growth factor (CTGF/CCN2) is a cysteine rich, extracellular matrix protein that acts as an anabolic growth factor to regulate osteoblast differentiation and function. In osteoblasts, CTGF is induced by TGF-beta1 where it acts as a d
Autor:
Reem A. Kanaan, Thomas A. Owen, Paul R. Odgren, Fayez F. Safadi, Sandy C. Marks, Steven L. Smock, Abdulhafez Selim, Jie Xu, Steven N. Popoff
Publikováno v:
Journal of Cellular Physiology. 196:51-62
Connective tissue growth factor (CTGF) is a secreted, extracellular matrix-associated signaling protein that regulates diverse cellular functions. In vivo, CTGF is expressed in many tissues with highest levels in the kidney and brain. The purpose of
Publikováno v:
Journal of Cellular Biochemistry. 84:12-26
Osteoblast development is a complex process involving the expression of specific growth factors and regulatory proteins that control cell proliferation, differentiation, and maturation. In this study, we used the rat mutation, osteopetrosis (op), to
Publikováno v:
Molecular Biology Reports. 28:235-243
Parathyroid hormone (PTH) is a major mediator of calcium and phosphate metabolism through its interactions with receptors in kidney and bone. PTH binds with high affinity to PTH1 and PTH2, members of the superfamily of G protein-coupled receptors. In
Publikováno v:
Molecular and Cellular Biochemistry. 226:129-140
Sex steroids, including testosterone, play a major role in determining peak bone mass in mammals and the subsequent loss of total bone mass with advancing age. Testosterone, and its active metabolite dihydrotestosterone (DHT), bind with high affinity
Autor:
Fayez F. Safadi, Andrew B. Rosenzweig, Steven N. Popoff, Sandy C. Marks, Steven L. Smock, Paul R. Odgren, Jie Xu, Thomas A. Owen
Publikováno v:
Journal of Cellular Biochemistry. 77:103-115
The mammalian osteopetroses represent a pathogenetically diverse group of skeletal disorders characterized by excess bone mass resulting from reduced osteoclastic bone resorption. Abnormalities involving osteoblast function and skeletal development h
Autor:
William A. Grasser, Steven L. Smock, Mark A. Thiede, David D. Thompson, Satoru K. Nishimoto, Donna N. Petersen
Publikováno v:
Endocrinology. 135:929-937
Osteocalcin (Oc), an abundant gamma-carboxylated protein (mol wt, 5800) of bone matrix, is used as a serum marker of bone turnover because it is considered to be uniquely synthesized by the osteoblast. Our finding of Oc messenger RNA (mRNA) in rat ti
Autor:
Lydia C. Pan, Vishwas M. Paralkar, D.T. Crawford, Thomas A. Owen, Thomas A. Brown, Kelly R. Long, Steven L. Smock, John E. Hambor, Mei Li, Peter C. Bonnette, Leonard Buckbinder, John Charles Kath, W. Gregory Roberts, David F. Gebhard, Hollis A. Simmons, Angel Guzman-Perez, Michael Joseph Luzzio, Catherine Angela Hulford, Hua Zhu Ke, Amy P. Baumann, Lisa M. Olson, Hong Qi, William A. Grasser
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 104(25)
Bone is accrued and maintained primarily through the coupled actions of bone-forming osteoblasts and bone-resorbing osteoclasts. Cumulative in vitro studies indicated that proline-rich tyrosine kinase 2 (PYK2) is a positive mediator of osteoclast fun