Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Steven L Andersen"'
Autor:
D. L. Wesche, Jonathan L. Vennerstrom, Geoffrey Edwards, Robert E. Miller, S. M. Walters, James K. Wood, Yuxiang Dong, Lucia Gerena, Wilbur K. Milhous, Arba L. Ager, H.-N. Fu, A. D. Holme, Dennis E. Kyle, Steven L. Andersen, W. G. Mclean
Publikováno v:
Journal of Medicinal Chemistry. 43:2753-2758
Sixteen alkyl-substituted dispiro-1,2,4,5-tetraoxanes (7,8,15, 16-tetraoxadispiro[5.2.5.2]hexadecanes) were synthesized to explore dispiro-1,2,4,5-tetraoxane SAR and to identify tetraoxanes with better oral antimalarial activity than prototype tetrao
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcce5723b02f43b61297b5e1ffbb6246
https://doi.org/10.1021/jm0000766
https://doi.org/10.1021/jm0000766
Autor:
Jonathan L. Vennerstrom, Arba L. Ager, Lucia Gerena, Steven L. Andersen, Wilbur K. Milhous, Robert G. Ridley, Arnulf Dorn
Publikováno v:
Journal of Medicinal Chemistry. 41:4360-4364
N,N-Bis(7-chloroquinolin-4-yl)heteroalkanediamines 1-11 were synthesized and screened against Plasmodium falciparum in vitro and Plasmodium berghei in vivo. These bisquinolines had IC50 values from 1 to 100 nM against P. falciparum in vitro. Six of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc984244a1589703942ec97f59ceb23b
https://doi.org/10.1021/jm9803828
https://doi.org/10.1021/jm9803828
Autor:
Arba L. Ager, James K. Wood, Hong Ning Fu, Jonathan L. Vennerstrom, William Y. Ellis, Wilbur K. Milhous, Lucia Gerena, Steven L. Andersen
Publikováno v:
Journal of Medicinal Chemistry. 35:3023-3027
Dispiro-1,2,4,5-tetraoxanes 2-4 were synthesized as potential peroxide antimalarial drugs. They had curative activity against Plasmodium berghei in vivo at single doses of 320 and 640 mg/kg which confirms earlier unpublished data. Moreover, artemisin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ed782671b5f2df5da40468bd9a8087e
https://doi.org/10.1021/jm00094a015
https://doi.org/10.1021/jm00094a015
Autor:
Steven L. Andersen, Jonathan L. Vennerstrom, Joanna K. Hu, James M. Grace, Arba L. Ager, Varima Wongpanich, David L. Wesche, Cindy K. Angerhofer
Publikováno v:
The American journal of tropical medicine and hygiene. 62(5)
The antimalarial peroxide, dispiro-1,2,4,5-tetraoxane WR 148999, was synergistic with chloroquine, quinine, mefloquine, and artemisinin against both D6 and W2 clones of Plasmodium falciparum. In consideration of the contrasting antagonism between art
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c8baff24c5ed7292dab1eef7ad2cf7d
https://pubmed.ncbi.nlm.nih.gov/11289666
https://pubmed.ncbi.nlm.nih.gov/11289666
Autor:
R. Rossan, Arba L. Ager, B. G. Schuster, Judith Berman, P. McGreevy, R. Kuschner, W. Ellis, D. Wesche, C. Ohrt, Steven L. Andersen
Publikováno v:
The American journal of tropical medicine and hygiene. 52(2)
We compared the efficacy of azithromycin to the clinical antimalarial doxycycline in Plasmodium berghei-infected mice and in P. falciparum-infected Aotus monkeys. When mice were administered drug orally twice a day for three days, the minimum total d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5b40908acd500c895190bf763c31eb5
https://pubmed.ncbi.nlm.nih.gov/7872444
https://pubmed.ncbi.nlm.nih.gov/7872444
Autor:
Steven L Andersen, Larry C Atha, David M Alabran, William T Beaudry, Austin H Beatty, Armand Balekdjian, Morria Azrin, Thomas B Bahder, Paul K Baker, Jack Alster
The 18th Army Science Conference was held at the Hyatt Hotel, Orlando, Florida, 22-25 June 1992. The conference presented a cross section of the many significant scientific and engineering programs carried out by the Department of the Army (DA). Addi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0661f8014ffb40ef228c8308973ddf20
https://doi.org/10.21236/ada259318
https://doi.org/10.21236/ada259318
Autor:
Jonathan L. Vennerstrom, Steven L. Andersen, Arba L. Ager, Lucia Gerena, William Y. Ellis, Wilbur K. Milhous
Publikováno v:
Journal of medicinal chemistry. 35(11)
On the basis of observations that several bisquinolines such as piperaquine possess notable activity against chloroquine-resistant malaria, 13 N,N-bis-(7-chloroquinolin-4-yl)alkanediamines were synthesized and screened against Plasmodium falciparum i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b839d7ce6b6a1a5fa9fec83fe0c88aee
https://pubmed.ncbi.nlm.nih.gov/1597862
https://pubmed.ncbi.nlm.nih.gov/1597862
Publikováno v:
Journal of medicinal chemistry. 35(9)
A series of dihydroartemisinin derivatives containing a sugar moiety was prepared in the search for analogues with good water solubility and high antimalarial activity. The preparation of the new compounds was achieved by treatment of dihydroartemisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce4f30ef7d1c07d9ed4c7ecc708e8ec0
https://pubmed.ncbi.nlm.nih.gov/1578492
https://pubmed.ncbi.nlm.nih.gov/1578492
Autor:
Judith Berman, Steven L. Andersen, P McGreevy, Arba L. Ager, Brian G. Schuster, William Y. Ellis
Publikováno v:
Antimicrobial Agents and Chemotherapy. 38:1862-1863
The efficacy of the newly marketed azalide azithromycin was compared with that of the clinical agent doxycycline in a murine model of sporozoite-induced malaria. Drug was administered once; Plasmodium yoelii sporozoites were administered 2 h later; s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11a79d35b561f6d43ede46f02da1dc87
https://doi.org/10.1128/aac.38.8.1862
https://doi.org/10.1128/aac.38.8.1862