An LRP1-binding motif in cellular prion protein replicates cell-signaling activities of the full-length protein

Autor: Elisabetta Mantuano, Carlotta Zampieri, Pardis Azmoon, Cory B. Gunner, Kyle R. Heye, Steven L. Gonias

Publikováno v: JCI Insight, Vol 8, Iss 15 (2023)

Low-density lipoprotein receptor-related protein-1 (LRP1) functions as a receptor for nonpathogenic cellular prion protein (PrPC), which is released from cells by ADAM (a disintegrin and metalloproteinase domain) proteases or in extracellular vesicle

Externí odkaz: https://doaj.org/article/afe55472c9374d5caabfd913552ed274

Fibrinolysis protease receptors promote activation of astrocytes to express pro-inflammatory cytokines

Autor: Paola Pontecorvi, Michael A. Banki, Carlotta Zampieri, Cristina Zalfa, Pardis Azmoon, Maria Z. Kounnas, Cinzia Marchese, Steven L. Gonias, Elisabetta Mantuano

Publikováno v: Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-14 (2019)

Abstract Background Astrocytes contribute to the crosstalk that generates chronic neuro-inflammation in neurological diseases; however, compared with microglia, astrocytes respond to a more limited continuum of innate immune system stimulants. Recent

Externí odkaz: https://doaj.org/article/c67ad0f1890e467e9e9e93cdbf827933

Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission

Autor: Smruthi Karthikeyan, Joshua I. Levy, Peter De Hoff, Greg Humphrey, Amanda Birmingham, Kristen Jepsen, Sawyer Farmer, Helena M. Tubb, Tommy Valles, Caitlin E. Tribelhorn, Rebecca Tsai, Stefan Aigner, Shashank Sathe, Niema Moshiri, Benjamin Henson, Adam M. Mark, Abbas Hakim, Nathan A. Baer, Tom Barber, Pedro Belda-Ferre, Marisol Chacón, Willi Cheung, Evelyn S. Cresini, Emily R. Eisner, Alma L. Lastrella, Elijah S. Lawrence, Clarisse A. Marotz, Toan T. Ngo, Tyler Ostrander, Ashley Plascencia, Rodolfo A. Salido, Phoebe Seaver, Elizabeth W. Smoot, Daniel McDonald, Robert M. Neuhard, Angela L. Scioscia, Alysson M. Satterlund, Elizabeth H. Simmons, Dismas B. Abelman, David Brenner, Judith C. Bruner, Anne Buckley, Michael Ellison, Jeffrey Gattas, Steven L. Gonias, Matt Hale, Faith Hawkins, Lydia Ikeda, Hemlata Jhaveri, Ted Johnson, Vince Kellen, Brendan Kremer, Gary Matthews, Ronald W. McLawhon, Pierre Ouillet, Daniel Park, Allorah Pradenas, Sharon Reed, Lindsay Riggs, Alison Sanders, Bradley Sollenberger, Angela Song, Benjamin White, Terri Winbush, Christine M. Aceves, Catelyn Anderson, Karthik Gangavarapu, Emory Hufbauer, Ezra Kurzban, Justin Lee, Nathaniel L. Matteson, Edyth Parker, Sarah A. Perkins, Karthik S. Ramesh, Refugio Robles-Sikisaka, Madison A. Schwab, Emily Spencer, Shirlee Wohl, Laura Nicholson, Ian H. McHardy, David P. Dimmock, Charlotte A. Hobbs, Omid Bakhtar, Aaron Harding, Art Mendoza, Alexandre Bolze, David Becker, Elizabeth T. Cirulli, Magnus Isaksson, Kelly M. Schiabor Barrett, Nicole L. Washington, John D. Malone, Ashleigh Murphy Schafer, Nikos Gurfield, Sarah Stous, Rebecca Fielding-Miller, Richard S. Garfein, Tommi Gaines, Cheryl Anderson, Natasha K. Martin, Robert Schooley, Brett Austin, Duncan R. MacCannell, Stephen F. Kingsmore, William Lee, Seema Shah, Eric McDonald, Alexander T. Yu, Mark Zeller, Kathleen M. Fisch, Christopher Longhurst, Patty Maysent, David Pride, Pradeep K. Khosla, Louise C. Laurent, Gene W. Yeo, Kristian G. Andersen, Rob Knight

Publikováno v: Nature. 609:101-108

As SARS-CoV-2 continues to spread and evolve, detecting emerging variants early is critical for public health interventions. Inferring lineage prevalence by clinical testing is infeasible at scale, especially in areas with limited resources, particip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc578e5c58cb6a0cf1c43406a685a849
https://doi.org/10.1038/s41586-022-05049-6

Supplemental Figure S3 from A Urokinase Receptor–Bim Signaling Axis Emerges during EGFR Inhibitor Resistance in Mutant EGFR Glioblastoma

Autor: Frank B. Furnari, Webster K. Cavenee, Steven L. Gonias, Paul S. Mischel, Clark C. Chen, Amy Haseley Thorne, Scott R. VandenBerg, Donald Pizzo, Genaro R. Villa, Tiffany Taylor, German G. Gomez, Jingjing Hu, Jill Wykosky

Supplemental Figure S3. Suppression of Akt activation in resistant clones

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c845e5a771cb5993c60fe09a7e8ba5fc
https://doi.org/10.1158/0008-5472.22407161.v1

Supplementary Figure 1 from Cell Signaling by Urokinase-type Plasminogen Activator Receptor Induces Stem Cell–like Properties in Breast Cancer Cells

Autor: Steven L. Gonias, Richard Klemke, Konstantin Stoletov, Drue L. Webb, Boryana M. Eastman, Minji Jo

Supplementary Figure 1 from Cell Signaling by Urokinase-type Plasminogen Activator Receptor Induces Stem Cell–like Properties in Breast Cancer Cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a34176ec20f4f063213b7229580c059
https://doi.org/10.1158/0008-5472.22385337