Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Steven L, Coon"'
Autor:
Michelle Bloyd, Ninet Sinaii, Fabio Rueda Faucz, James Iben, Steven L. Coon, Sonia Caprio, Nicola Santoro, Constantine A. Stratakis, Edra London
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionPediatric obesity has steadily increased in recent decades. Large-scale genome-wide association studies (GWAS) conducted primarily in Eurocentric adult populations have identified approximately 100 loci that predispose to obesity and type
Externí odkaz:
https://doaj.org/article/3c73aefed5704116b3d0233a2c31eb5f
Autor:
Vipula Kolli, Isabela Werneck da Cunha, SunA Kim, James R. Iben, Ashwini Mallappa, Tianwei Li, Alison Gaynor, Steven L. Coon, Martha M. Quezado, Deborah P. Merke
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
IntroductionAdrenocortical hyperplasia and adrenal rest tumor (ART) formation are common in congenital adrenal hyperplasia (CAH). Although driven by excessive corticotropin, much is unknown regarding the morphology and transformation of these tissues
Externí odkaz:
https://doaj.org/article/67e33a0b635a4f8b89d5da329b38efec
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
GRTH/DDX25 is a member of the DEAD-box family of RNA helicases that play an essential role in spermatogenesis. GRTH knock-in (KI) mice with the human mutant GRTH gene (R242H) show loss of the phospho-species from cytoplasm with preservation of the no
Externí odkaz:
https://doaj.org/article/c80d02158d404cbaa0e9481f149daa61
Publikováno v:
eLife, Vol 9 (2020)
La-related protein 4 (LARP4) directly binds both poly(A) and poly(A)-binding protein (PABP). LARP4 was shown to promote poly(A) tail (PAT) lengthening and stabilization of individual mRNAs presumably by protection from deadenylation (Mattijssen et al
Externí odkaz:
https://doaj.org/article/7557de12046e44d5bb574cef4bf3dcfd
Autor:
Patrick A. Fletcher, Kosara Smiljanic, Rafael Maso Prévide, James R. Iben, Tianwei Li, Milos B. Rokic, Arthur Sherman, Steven L. Coon, Stanko S. Stojilkovic
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
Understanding the physiology and pathology of an organ composed of a variety of cell populations depends critically on genome-wide information on each cell type. Here, we report single-cell transcriptome profiling of over 6,800 freshly dispersed ante
Externí odkaz:
https://doaj.org/article/70449262d98043f5872fe663ac712568
Autor:
Steven L. Coon, Cong Fu, Steven W. Hartley, Lynne Holtzclaw, Joseph C. Mays, Michael C. Kelly, Matthew W. Kelley, James C. Mullikin, Martin F. Rath, Luis E. Savastano, David C. Klein
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
The analysis of pineal cell biology has undergone remarkable development as techniques have become available which allow for sequencing of entire transcriptomes and, most recently, the sequencing of the transcriptome of individual cells. Identificati
Externí odkaz:
https://doaj.org/article/a35022ada9834e1dbaed35ec1738f7d2
Autor:
Joseph C Mays, Michael C Kelly, Steven L Coon, Lynne Holtzclaw, Martin F Rath, Matthew W Kelley, David C Klein
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205883 (2018)
The vertebrate pineal gland is dedicated to the production of the hormone melatonin, which increases at night to influence circadian and seasonal rhythms. This increase is associated with dramatic changes in the pineal transcriptome. Here, single-cel
Externí odkaz:
https://doaj.org/article/74cddffafb5c466ba4bc65cb63af3525
Autor:
Steven L, Coon, David C, Klein
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2550
The isolation of single cells from the pineal gland plays an essential role in understanding the complex nature of such processes as differentiation, metabolism, and cell-cell communication within the pineal gland. This procedure is the portal to sin
Autor:
Steven L, Coon, David C, Klein
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2550
The pineal gland presents a powerful genetic tool to study a broad range of physiological processes. It has been instrumental as a model in understanding transduction processes and daily changes in gene expression and holds great promise in understan
Autor:
David C, Klein, Steven L, Coon
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2550
The pineal transcriptome webpage is described, which provides access to the transcript expression profile of the vertebrate pineal gland and, in many cases, the retina. Experimental material was obtained during the day and night, providing an opportu