Výsledky vyhledávání - "Steven Knopf"

Nicotine suppresses the proliferative response of peripheral blood lymphocytes in rats

Autor: Kenneth A. Perkins, Seymour M. Antelman, Cathy G. McAllister, S. Saylor, Leonard H. Epstein, Steven Knopf, Anthony R. Caggiula

Publikováno v: Drug Development Research. 26:473-479

Nicotine, the psychoactive ingredient of cigarette smoke, alters lymphocyte function in vitro. However, unlike tobacco smoke, the immunologic effects of nicotine in vivo have not been determined. In the present study a single SC administration of 0.3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c517475a96f893bab81e2eca781d6a73
https://doi.org/10.1002/ddr.430260411

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Conditioned tolerance to the anorectic and corticosterone-elevating effects of nicotine

Autor: Steven Knopf, S. Saylor, Anthony R. Caggiula, Kenneth A. Perkins, Richard L. Stiller, Leonard H. Epstein, Seymour M. Antelman

Publikováno v: Pharmacology Biochemistry and Behavior. 40:53-59

We have shown that tolerance to the behavioral effects of nicotine is partially dependent on conditioned environmental cues that predict drug delivery. The present research extends this finding to physiological effects of nicotine by assessing both t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de7c834293b1a745dfda5e9b57603d77
https://doi.org/10.1016/0091-3057(91)90319-w

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Nicotine self-administration in rats

Autor: C Brown, Anthony R. Caggiula, Eric C. Donny, Steven Knopf

Publikováno v: Psychopharmacology. 122(4)

Considering the importance of self-administration models in determining mechanisms of drug maintained behavior, we attempted to replicate the findings of nicotine self-administration by Corrigall and Coen. Male, Sprague-Dawley rats, trained on food r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5800ced5918c9e8e199be1014a54f2d
https://pubmed.ncbi.nlm.nih.gov/8657839

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Conditioned Tolerance to Nicotine in Rats

Autor: Kenneth A. Perkins, Steven Knopf, Eric C. Donny, S. Saylor, Anthony R. Caggiula, Seymour M. Antelman, Leonard H. Epstein, Richard L. Stiller

Publikováno v: Effects of Nicotine on Biological Systems II ISBN: 9783034874472

Evidence is reviewed for the role of conditioning in tolerance to nicotine. Possible mechanisms are discussed, including the hypothesis that a conditioned release of adrenal steroids may mediate conditioned tolerance to some of nicotine’s effects.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9de8e691e806db9b11d97bd380183126
https://doi.org/10.1007/978-3-0348-7445-8_13

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Immunological effects of acute and chronic nicotine administration in rats

Autor: Anna L. Miller, Anthony R. Caggiula, Steven Knopf, Leonard H. Epstein, Seymour M. Antelman, Cathy G. McAllister, Kenneth A. Perkins

Publikováno v: Journal of neuroimmunology. 50(1)

We previously demonstrated that acute nicotine administration decreased the response of rat blood leukocytes (PBL) to concanavalin A (ConA). We now extend those findings to a comparison between the effects of acute and prolonged nicotine exposure (te

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9667262f34b02a8daa84f5f4432c66a0
https://pubmed.ncbi.nlm.nih.gov/8300857

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Acute stress or corticosterone administration reduces responsiveness to nicotine: implications for a mechanism of conditioned tolerance

Autor: Kenneth A. Perkins, Richard L. Stiller, Anthony R. Caggiula, S. Saylor, Seymour M. Antelman, Leonard H. Epstein, Steven Knopf

Publikováno v: Psychopharmacology. 111(4)

We have shown that conditioned tolerance develops to some of the behavioral and endocrine effects of nicotine in rats. Other investigators have suggested that tolerance to multiple nicotine injections in mice may be due, in part, to elevated plasma c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d59bbab0f2de0aac8902b68884dd70f
https://pubmed.ncbi.nlm.nih.gov/7870994

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One brief exposure to a psychological stressor induces long-lasting, time-dependent sensitization of both the cataleptic and neurochemical responses to haloperidol

Autor: Steven Knopf, Anthony R. Caggiula, Donna Kocan, Seymour M. Antelman, David J. Edwards

Publikováno v: Life sciences. 51(4)

Rats were exposed for 10 minutes to one of several enclosures graded in novelty. In one experiment they were then simply sacrificed and plasma corticosterone determinations made in order to obtain an index of the relative stressfulness of these enclo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f44b1ed5ff81789a502f38ea5f8fa35
https://pubmed.ncbi.nlm.nih.gov/1625517

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Amphetamine or haloperidol 2 weeks earlier antagonized the plasma corticosterone response to amphetamine; evidence for the stressful/foreign nature of drugs

Autor: Donna Kocan, David J. Edwards, Anthony R. Caggiula, Seymour M. Antelman, Steven Knopf

Publikováno v: Psychopharmacology. 107(2-3)

We inquired whether a single exposure to amphetamine (AM) or haloperidol (HALO) could modify the plasma corticosterone (CORT) response to a second injection of AM 2 weeks later. Male rats were injected with 4 mg/kgd-AM sulfate and tested for water in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c12a19d2e05594bc81e487e78efca27
https://pubmed.ncbi.nlm.nih.gov/1615134

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