Výsledky vyhledávání - "Steven K. Laughlin"

The development of monocyclic pyrazolone based cytokine synthesis inhibitors

Autor: Michael J. Janusz, R.L. Walter, John C. VanRens, Biswanath De, Lily C. Hsieh, Jane Far-Jine Djung, Cynthia Monesa Clark, Steven K. Laughlin, Marlene Mekel, Mark Sabat, Matthew J. Laufersweiler, Todd A. Brugel, Townes Jennifer Anne, Adam Golebiowski, Roger G. Bookland, Mark E. Webster, Michael P. Clark

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 15:2285-2289

4-Aryl-5-pyrimidyl based cytokine synthesis inhibitors that contain a novel monocyclic, pyrazolone heterocyclic core are described. Many of these inhibitors showed low nanomolar activity against LPS-induced TNF-α production. One of the compounds (6e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ac5ff7c8d61ec4513b9cc74ef54a58d
https://doi.org/10.1016/j.bmcl.2005.03.007

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The development of novel inhibitors of tumor necrosis factor-α (TNF-α) production based on substituted [5,5]-bicyclic pyrazolones

Autor: John C. VanRens, Adam Golebiowski, Matthew J. Laufersweiler, Lily C. Hsieh, Steven K. Laughlin, Biswanath De, Todd A. Brugel, Marlene Mekel, Michael J. Janusz, Townes Jennifer Anne, Roger G. Bookland, Karen Juergens, R.L. Walter, Sandra A. Heitmeyer, Kimberly K. Brown, Mark Sabat, Michael P. Clark

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 14:4267-4272

Novel substituted [5,5]-bicyclic pyrzazolones are presented as inhibitors of tumor necrosis factor-alpha (TNF-alpha) production. Many of these compounds show low nanomolar activity against lipopolysaccaride (LPS)-induced TNF-alpha production in THP-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::175790dc397863d0c9c125c5e392f266
https://doi.org/10.1016/j.bmcl.2004.06.001

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Destruction of Polycyclic Aromatic Hydrocarbons with Ultrasound

Autor: Steven K. Laughlin, William H. Buttermore, A. P. D'Silva, Stephan J. Weeks

Publikováno v: Polycyclic Aromatic Compounds. 1:125-135

Dilute ethanol-water solutions of a few polycyclic aromatic hydrocarbons, a dioxin, and neat chlorinated solvents were sonicated and then characterized by UV-visible absorption spectrophotometry and laser excited Shpol'skii spectrometry. The results

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aee7e85c60b20ce60eb9ac73d1398c0c
https://doi.org/10.1080/10406639008034756

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Development of new pyrrolopyrimidine-based inhibitors of Janus kinase 3 (JAK3)

Autor: Adam Golebiowski, Kumar D. Thakur, Biswanath De, Michael P. Clark, John C. VanRens, Vijay Easwaran, Ed J. Cabrera, Matthew J. Laufersweiler, Jan Richard Davis, Jennifer A. Maier, Mark Sabat, Steven K. Laughlin, Kelly M. George, Jack J. Chen, Roger G. Bookland, Todd A. Brugel, Mark E. Webster, Wenlin Lee, George Zhang

Publikováno v: Bioorganicmedicinal chemistry letters. 17(5)

A new class of bicyclic pyrrolopyrimidine-based Janus kinase 3 (JAK-3) inhibitors are described. Many of these inhibitors showed low nanomolar activity against JAK-3.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b0b6d0b710b5d1743a0cc792f1f7cc7
https://pubmed.ncbi.nlm.nih.gov/17189692

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Development of pyrimidine-based inhibitors of Janus tyrosine kinase 3

Autor: Jan Richard Davis, Kumar D. Thakur, Biswanath De, Kelly M. George, Steven K. Laughlin, Vijay Easwaran, Jack J. Chen, Roger G. Bookland, Edward J. Cabrera, Y. George Zhang, Michael P. Clark

Publikováno v: Bioorganicmedicinal chemistry letters. 16(21)

A new class of pyrimidine-based Janus tyrosine kinase 3 (JAK3) inhibitors are described. Many of these inhibitors showed low nanomolar activity against JAK3.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::600302d42a8ab7c988913cdaaba19c96
https://pubmed.ncbi.nlm.nih.gov/16934457

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Development of N-2,4-pyrimidine-N-phenyl-N'-phenyl ureas as inhibitors of tumor necrosis factor alpha (TNF-alpha) synthesis. Part 1

Autor: Todd A. Brugel, Biswanath De, Adam Golebiowski, Marlene Mekel, Michael P. Clark, Roger G. Bookland, Michael J. Janusz, John C. VanRens, Mark Sabat, Steven K. Laughlin, Jennifer A. Maier, Matthew J. Laufersweiler, Lily C. Hsieh

Publikováno v: Bioorganicmedicinal chemistry letters. 16(13)

A new class of tumor necrosis factor alpha (TNF-alpha) synthesis inhibitors based on an N-2,4-pyrimidine-N-phenyl-N'-phenyl urea scaffold is described. Many of these compounds showed low-nanomolar activity against lipopolysaccharide stimulated TNF-al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d3612f04dcea242d07cd2de769ea75
https://pubmed.ncbi.nlm.nih.gov/16632356

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The development of new isoxazolone based inhibitors of tumor necrosis factor-alpha (TNF-alpha) production

Autor: Steven K. Laughlin, Michael P. Clark, Jane F. Djung, Adam Golebiowski, Todd A. Brugel, Mark Sabat, Roger G. Bookland, Matthew J. Laufersweiler, John C. VanRens, Jennifer A. Townes, Biswanath De, Lily C. Hsieh, Susan C. Xu, Richard L. Walter, Marlene J. Mekel, Michael J. Janusz

Publikováno v: Bioorganicmedicinal chemistry letters. 15(9)

4-Aryl-3-pyridyl and 4-aryl-3-pyrimidinyl based tumor necrosis factor-alpha (TNF-alpha) inhibitors, which contain a novel isoxazolone five-membered heterocyclic core are described. Many showed sub-micromolar activity against lipopolysaccharide-induce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2317a6e0e2ea3c47c2980e8f00d29170
https://pubmed.ncbi.nlm.nih.gov/15837333

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Development of orally bioavailable bicyclic pyrazolones as inhibitors of tumor necrosis factor-alpha production

Publikováno v: Journal of medicinal chemistry. 47(11)

2-Aryl-3-pyrimidinyl based tumor necrosis factor-alpha (TNF-alpha) inhibitors, which contain a novel bicyclic pyrazolone core, are described. Many showed low-nanomolar activity against lipopolysaccharide-induced TNF-alpha production in monocytic cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56718fa4dbfa1e69d8b205c479c1a59a
https://pubmed.ncbi.nlm.nih.gov/15139749

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Corrigendum to 'Development of N-2,4-pyrimidine-N-phenyl-N′-phenyl ureas as inhibitors of tumor necrosis factor alpha (TNF-α) synthesis. Part 1' [Bioorg. Med. Chem. Lett. 16 (2006) 3510–3513]

Autor: Mark Sabat, Matthew J. Laufersweiler, Jennifer A. Maier, Marlene Mekel, Michael J. Janusz, Biswanath De, Todd A. Brugel, Lily C. Hsieh, Michael P. Clark, Adam Golebiowski, Roger G. Bookland, Steven K. Laughlin, John C. VanRens

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 16:4700

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb23aaceeb07bea1431690a4d7ab1c0d
https://doi.org/10.1016/j.bmcl.2006.06.013

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