Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Steven K. Duddy"'
Autor:
William C. Mobley, Robert A. Rissman, Gopal Thinakaran, Brian P. Head, Rudolph E. Tanzi, Steven K. Duddy, Yuhuan Xie, Moorthi Ponnusamy, Michael Mante, Jiunn H. Lin, Olga Prikhodko, Ann Becker, Brian Spencer, Kevin D. Rynearson, Steven L. Wagner, Brenda Hug, Douglas Galasko, Graham Johnson, Bahar Salehi, Jazmin Florio, Can Zhang, Mariko Sawa, Carlos Arias, Phuong Nguyen
Publikováno v:
The Journal of Experimental Medicine
Journal of Experimental Medicine, vol 218, iss 4
Journal of Experimental Medicine, vol 218, iss 4
GSMs preferentially attenuate levels of the aggregation-prone Aβ42 peptide by binding to the γ-secretase enzyme and altering exopeptidase-like processing. Rynearson et al. demonstrate the ability of an advanced-stage GSM to robustly attenuate Aβ42
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce9c02e75bda1fdeb22284485c3ed260
http://europepmc.org/articles/PMC7931646
http://europepmc.org/articles/PMC7931646
Autor:
Robert A. Rissman, Phuong Nguyen, Weiming Xia, Doo Yeon Kim, Deborah Masliah, Steven K. Duddy, Louise Monte, Ann Becker, Graham Johnson, Jiunn H. Lin, Can Zhang, Kevin D. Rynearson, William C. Mobley, Corinne M. Echmalian, Rudolph E. Tanzi, Steven L. Wagner, Uyen Vo, Justin B. Klee, Luisa Quinti
Publikováno v:
The Journal of pharmacology and experimental therapeutics, vol 362, iss 1
The Journal of Pharmacology and Experimental Therapeutics
The Journal of Pharmacology and Experimental Therapeutics
Alzheimer's disease (AD) is characterized neuropathologically by an abundance of 1) neuritic plaques, which are primarily composed of a fibrillar 42-amino-acid amyloid-β peptide (Aβ), as well as 2) neurofibrillary tangles composed of aggregates of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0a46fd75288db093dbde82421751825
https://escholarship.org/uc/item/6n31h1k9
https://escholarship.org/uc/item/6n31h1k9
Publikováno v:
Toxicology and Applied Pharmacology. 160:133-140
Hemangiosarcomasare uncommon malignant endothelial cell tumors in humans and experimental animal species. The mechanisms giving rise to these tumors are poorly understood even though the histotypes are comparable between humans and rodents. Activatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f9ade2af3b6fd0ef5ffa26d68ec7bbf
https://doi.org/10.1006/taap.1999.8763
https://doi.org/10.1006/taap.1999.8763
Publikováno v:
Toxicological Sciences. 46:317-323
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcc9a1f888b36164bc1fcbb3b3d44786
https://doi.org/10.1093/toxsci/46.2.317
https://doi.org/10.1093/toxsci/46.2.317
Autor:
Steven K. Duddy, George E.N. Kass, Annie Gahm, Juan Llopis, Sten Orrenius, Geoffrey C. Farrell
Publikováno v:
Biochemical Pharmacology. 45:2209-2214
In the isolated perfused rat liver 2,5-di(tert-butyl)hydroquinone (tBuHQ), a selective inhibitor of the endoplasmic reticulum Ca2+ pump, induces a prolonged glucose output and stimulates Ca2+ efflux. The present study shows that tBuHQ depleted the ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a482d025e1157e696d5807328d3c77a
https://doi.org/10.1016/0006-2952(93)90191-x
https://doi.org/10.1016/0006-2952(93)90191-x
Autor:
Sten Orrenius, George E.N. Kass, Juan Llopis, Geoffrey C. Farrell, Steven K. Duddy, Gregory A. Moore
Publikováno v:
Free Radical Research Communications. 8:337-345
Isolated hepatocytes and the isolated perfused rat liver have been used to study the alterations of cytosolic free Ca2+ concentration ([Ca2+]i) produced by 2,5-di(tert-butyl)-1,4-benzohydroquinone (tBuBHQ), a potent inhibitor of hepatic microsomal Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f121dcf093e711623cb7e447b544110
https://doi.org/10.3109/10715769009053367
https://doi.org/10.3109/10715769009053367
Autor:
Felix A. de la Iglesia, Susanne Gorospe, Steven K. Duddy, Robert F. Parker, Alexander W. Gough, Michael R. Bleavins, Paul E. Rowse, L. A. Dethloff
Publikováno v:
Toxicology and applied pharmacology. 156(2)
Hemangiomas and hemangiosarcomas are uncommon in rodents and humans and, as such, the mechanisms giving rise to these tumors are poorly understood. Inactivating mutations in the p53 gene have been detected in sporadic and chemically induced human and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22430a825f5a935575cb6fcb6367c3d6
https://pubmed.ncbi.nlm.nih.gov/10198275
https://pubmed.ncbi.nlm.nih.gov/10198275
Autor:
Sten Orrenius, Juan Llopis, Geoffrey C. Farell, Annie Gahm, Steven K. Duddy, George E.N. Kass
Publikováno v:
FEBS letters. 280(1)
Hepatocyte tight junctional permeability has been shown to be regulated by hormones that exert their effects via phospholipase C activation. However, the precise transduction pathway involved in this effect is not known. The present study has employe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b402269af6d67f1e6a5ba22cb9fe1bc7
https://pubmed.ncbi.nlm.nih.gov/2009970
https://pubmed.ncbi.nlm.nih.gov/2009970
The hypothesis that monohydroxy bile acids exert their cholestatic and hepatotoxic effects via a sustained elevation of cytosolic [Ca2+] was tested in the isolated perfused rat liver. Infusion of the specific inhibitor of microsomal Ca2+ sequestratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ff0b9cd64779bae7503286e4bd0125
https://europepmc.org/articles/PMC296560/
https://europepmc.org/articles/PMC296560/