Zobrazeno 1 - 10
of 447
pro vyhledávání: '"Steven K Libutti"'
Autor:
Amit Singla, Nicholas B Dadario, Ashima Singla, Patricia Greenberg, Rachel Yan, Anil Nanda, Detlev Boison, Rakesh Malhotra, Sunil Patel, Suri Nipun, Kaur Maninderpal, Dorothy Castro, Sanaa Bdiiwi, Hala Boktor, Htay Htay Kyi, Anne Sutherland, Amee Patrawalla, Kevin Ly, Yingda Xie, Ashish Sonig, Priyank Khandelwal, James Liu, Joseph Koziol, Diana Finkle, Sara Subanna, Steven K Libutti
Publikováno v:
PLoS ONE, Vol 18, Iss 1, p e0274243 (2023)
BackgroundCoronavirus disease 2019 (COVID-19) is an immunoinflammatory and hypercoagulable state that contributes to respiratory distress, multi-organ dysfunction, and mortality. Dipyridamole, by increasing extracellular adenosine, has been postulate
Externí odkaz:
https://doaj.org/article/fa87c54409534a849287240f04273a0d
Autor:
Robert H Shoemaker, Reynold A Panettieri, Steven K Libutti, Howard S Hochster, Norman R Watts, Paul T Wingfield, Philipp Starkl, Lisabeth Pimenov, Riem Gawish, Anastasiya Hladik, Sylvia Knapp, Daniel Boring, Jonathan M White, Quentin Lawrence, Jeremy Boone, Jason D Marshall, Rebecca L Matthews, Brian D Cholewa, Jeffrey W Richig, Ben T Chen, David L McCormick, Romana Gugensberger, Sonja Höller, Josef M Penninger, Gerald Wirnsberger
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0271066 (2022)
As ACE2 is the critical SARS-CoV-2 receptor, we hypothesized that aerosol administration of clinical grade soluble human recombinant ACE2 (APN01) will neutralize SARS-CoV-2 in the airways, limit spread of infection in the lung, and mitigate lung dama
Externí odkaz:
https://doaj.org/article/de12786ecde24914a9f12e92f2296a6a
Autor:
Joseph D Butner, Geoffrey V Martin, Zhihui Wang, Bruna Corradetti, Mauro Ferrari, Nestor Esnaola, Caroline Chung, David S Hong, James W Welsh, Naomi Hasegawa, Elizabeth A Mittendorf, Steven A Curley, Shu-Hsia Chen, Ping-Ying Pan, Steven K Libutti, Shridar Ganesan, Richard L Sidman, Renata Pasqualini, Wadih Arap, Eugene J Koay, Vittorio Cristini
Publikováno v:
eLife, Vol 10 (2021)
Background: Checkpoint inhibitor therapy of cancer has led to markedly improved survival of a subset of patients in multiple solid malignant tumor types, yet the factors driving these clinical responses or lack thereof are not known. We have develope
Externí odkaz:
https://doaj.org/article/fb8dc9b236644627993affff85ba8824
Autor:
Wendy M McKimpson, Ziqiang Yuan, Min Zheng, Judy S Crabtree, Steven K Libutti, Richard N Kitsis
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145792 (2015)
Multiple endocrine neoplasia type 1 (MEN1) is a genetic disorder characterized by tissue-specific tumors in the endocrine pancreas, parathyroid, and pituitary glands. Although tumor development in these tissues is dependent upon genetic inactivation
Externí odkaz:
https://doaj.org/article/13aff3c331394bbdac665a816278bc7d
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82620 (2013)
Identifying key mediators of cancer cell invasion and metastasis is critical to the development of more effective cancer therapies. We previously identified Filamin A interacting protein 1-like (FILIP1L) as an important inhibitor of cell migration an
Externí odkaz:
https://doaj.org/article/d51c766a92924dcdb2434ded4160228c
Autor:
H-C Jennifer Shen, Asha Adem, Kris Ylaya, Arianne Wilson, Mei He, Dominique Lorang, Stephen M Hewitt, Klaus Pechhold, David M Harlan, Irina A Lubensky, Laura S Schmidt, W Marston Linehan, Steven K Libutti
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e4897 (2009)
The von Hippel-Lindau (VHL) syndrome is a pleomorphic familial disease characterized by the development of highly vascularized tumors, such as hemangioblastomas of the central nervous system, pheochromocytomas, renal cell carcinomas, cysts and neuroe
Externí odkaz:
https://doaj.org/article/75dfb8e97c4249dcae4be14f918e358f
Autor:
Melissa C Paoloni, Anita Tandle, Christina Mazcko, Engy Hanna, Stefan Kachala, Amy Leblanc, Shelley Newman, David Vail, Carolyn Henry, Douglas Thamm, Karin Sorenmo, Amin Hajitou, Renata Pasqualini, Wadih Arap, Chand Khanna, Steven K Libutti
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e4972 (2009)
Under the direction and sponsorship of the National Cancer Institute, we report on the first pre-clinical trial of the Comparative Oncology Trials Consortium (COTC). The COTC is a novel infrastructure to integrate cancers that naturally develop in pe
Externí odkaz:
https://doaj.org/article/c5b6037943c7447f9f8bb2f08c0dda5e
Publikováno v:
Molecular Imaging, Vol 2 (2003)
Recently, there has been tremendous interest in developing techniques such as MRI, micro-CT, micro-PET, and SPECT to image function and processes in small animals. These technologies offer deep tissue penetration and high spatial resolution, but comp
Externí odkaz:
https://doaj.org/article/bf62d19d494443f1b06f54bd840fd648
Autor:
Steven Xie, Jonathan Kuriakose, Toni Beninato, Mary Carayannopoulos, Stanley Z Trooskin, Steven K Libutti, Amanda M Laird
Publikováno v:
Journal of the American College of Surgeons. 235:906-912
Autor:
Mijung Kwon, Genesaret Rubio, Haitao Wang, Gregory Riedlinger, Asha Adem, Hua Zhong, Daniel Slegowski, Louisa Post-Zwicker, Anshruta Chidananda, David S. Schrump, Sharon R. Pine, Steven K. Libutti
Publikováno v:
Cancer Research Communications. 2:1197-1213
Lung adenocarcinoma (LUAD) is the major subtype in lung cancer, and cigarette smoking is essentially linked to its pathogenesis. We show that downregulation of Filamin A interacting protein 1-like (FILIP1L) is a driver of LUAD progression. Cigarette