Zobrazeno 1 - 10
of 677
pro vyhledávání: '"Steven K Libutti"'
Autor:
Amit Singla, Nicholas B Dadario, Ashima Singla, Patricia Greenberg, Rachel Yan, Anil Nanda, Detlev Boison, Rakesh Malhotra, Sunil Patel, Suri Nipun, Kaur Maninderpal, Dorothy Castro, Sanaa Bdiiwi, Hala Boktor, Htay Htay Kyi, Anne Sutherland, Amee Patrawalla, Kevin Ly, Yingda Xie, Ashish Sonig, Priyank Khandelwal, James Liu, Joseph Koziol, Diana Finkle, Sara Subanna, Steven K Libutti
Publikováno v:
PLoS ONE, Vol 18, Iss 1, p e0274243 (2023)
BackgroundCoronavirus disease 2019 (COVID-19) is an immunoinflammatory and hypercoagulable state that contributes to respiratory distress, multi-organ dysfunction, and mortality. Dipyridamole, by increasing extracellular adenosine, has been postulate
Externí odkaz:
https://doaj.org/article/fa87c54409534a849287240f04273a0d
Autor:
Natalie Bruiners, Valentina Guerrini, Rahul Ukey, Ryan J. Dikdan, Jason H. Yang, Pankaj Kumar Mishra, Alberta Onyuka, Deborah Handler, Joshua Vieth, Mary Carayannopoulos, Shuang Guo, Maressa Pollen, Abraham Pinter, Sanjay Tyagi, Daniel Feingold, Claire Philipp, Steven K. Libutti, Maria Laura Gennaro
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
While the biomarkers of COVID-19 severity have been thoroughly investigated, the key biological dynamics associated with COVID-19 resolution are still insufficiently understood. We report a case of full resolution of severe COVID-19 due to convalesce
Externí odkaz:
https://doaj.org/article/b96a43803cf541658a9aa9a127096866
Publikováno v:
European Journal of Cell Biology, Vol 101, Iss 3, Pp 151240- (2022)
Amino Acids are not only major nutrient sources, but also serve as chemical signals to control cellular growth. Rab1A recently emerged as a key component in amino acid sensing and signaling to activate the mTOR complex1 (mTORC1). In a recently publis
Externí odkaz:
https://doaj.org/article/6af013365df4401ea04ecc4c65120049
Autor:
Robert H Shoemaker, Reynold A Panettieri, Steven K Libutti, Howard S Hochster, Norman R Watts, Paul T Wingfield, Philipp Starkl, Lisabeth Pimenov, Riem Gawish, Anastasiya Hladik, Sylvia Knapp, Daniel Boring, Jonathan M White, Quentin Lawrence, Jeremy Boone, Jason D Marshall, Rebecca L Matthews, Brian D Cholewa, Jeffrey W Richig, Ben T Chen, David L McCormick, Romana Gugensberger, Sonja Höller, Josef M Penninger, Gerald Wirnsberger
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0271066 (2022)
As ACE2 is the critical SARS-CoV-2 receptor, we hypothesized that aerosol administration of clinical grade soluble human recombinant ACE2 (APN01) will neutralize SARS-CoV-2 in the airways, limit spread of infection in the lung, and mitigate lung dama
Externí odkaz:
https://doaj.org/article/de12786ecde24914a9f12e92f2296a6a
Autor:
Amber Gonda, Nanxia Zhao, Jay V. Shah, Jake N. Siebert, Srujanesh Gunda, Berk Inan, Mijung Kwon, Steven K. Libutti, Prabhas V. Moghe, Nicola L. Francis, Vidya Ganapathy
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
BackgroundLate-stage diagnosis of ovarian cancer, a disease that originates in the ovaries and spreads to the peritoneal cavity, lowers 5-year survival rate from 90% to 30%. Early screening tools that can: i) detect with high specificity and sensitiv
Externí odkaz:
https://doaj.org/article/4f7534a0ee9e4be0952e2d43d5e9bfdc
Autor:
Joseph D Butner, Geoffrey V Martin, Zhihui Wang, Bruna Corradetti, Mauro Ferrari, Nestor Esnaola, Caroline Chung, David S Hong, James W Welsh, Naomi Hasegawa, Elizabeth A Mittendorf, Steven A Curley, Shu-Hsia Chen, Ping-Ying Pan, Steven K Libutti, Shridar Ganesan, Richard L Sidman, Renata Pasqualini, Wadih Arap, Eugene J Koay, Vittorio Cristini
Publikováno v:
eLife, Vol 10 (2021)
Background: Checkpoint inhibitor therapy of cancer has led to markedly improved survival of a subset of patients in multiple solid malignant tumor types, yet the factors driving these clinical responses or lack thereof are not known. We have develope
Externí odkaz:
https://doaj.org/article/fb8dc9b236644627993affff85ba8824
Autor:
Mark N. Stein, Jyoti Malhotra, Rohinton S. Tarapore, Usha Malhotra, Ann W. Silk, Nancy Chan, Lorna Rodriguez, Joseph Aisner, Robert D. Aiken, Tina Mayer, Bruce G. Haffty, Jenna H. Newman, Salvatore M. Aspromonte, Praveen K. Bommareddy, Ricardo Estupinian, Charles B. Chesson, Evita T. Sadimin, Shengguo Li, Daniel J. Medina, Tracie Saunders, Melissa Frankel, Aparna Kareddula, Sherrie Damare, Elayne Wesolowsky, Christian Gabel, Wafik S. El-Deiry, Varun V. Prabhu, Joshua E. Allen, Martin Stogniew, Wolfgang Oster, Joseph R. Bertino, Steven K. Libutti, Janice M. Mehnert, Andrew Zloza
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-9 (2019)
Abstract Background ONC201 is a small molecule antagonist of DRD2, a G protein-coupled receptor overexpressed in several malignancies, that has prolonged antitumor efficacy and immunomodulatory properties in preclinical models. The first-in-human tri
Externí odkaz:
https://doaj.org/article/cc2e3e6b70b34104941a2588a1bfa557
Autor:
Steven Xie, Jonathan Kuriakose, Toni Beninato, Mary Carayannopoulos, Stanley Z Trooskin, Steven K Libutti, Amanda M Laird
Publikováno v:
Journal of the American College of Surgeons. 235:906-912
Autor:
Mijung Kwon, Genesaret Rubio, Haitao Wang, Gregory Riedlinger, Asha Adem, Hua Zhong, Daniel Slegowski, Louisa Post-Zwicker, Anshruta Chidananda, David S. Schrump, Sharon R. Pine, Steven K. Libutti
Publikováno v:
Cancer Research Communications. 2:1197-1213
Lung adenocarcinoma (LUAD) is the major subtype in lung cancer, and cigarette smoking is essentially linked to its pathogenesis. We show that downregulation of Filamin A interacting protein 1-like (FILIP1L) is a driver of LUAD progression. Cigarette
Autor:
Huan Wang, Aaron Bender, Peng Wang, Esra Karakose, William B. Inabnet, Steven K. Libutti, Andrew Arnold, Luca Lambertini, Micheal Stang, Herbert Chen, Yumi Kasai, Milind Mahajan, Yayoi Kinoshita, Gustavo Fernandez-Ranvier, Thomas C. Becker, Karen K. Takane, Laura A. Walker, Shira Saul, Rong Chen, Donald K. Scott, Jorge Ferrer, Yevgeniy Antipin, Michael Donovan, Andrew V. Uzilov, Boris Reva, Eric E. Schadt, Bojan Losic, Carmen Argmann, Andrew F. Stewart
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Diabetes results in part from a deficiency of functional pancreatic beta cells. Here, the authors study the genomic and epigenetic landscapes of human insulinomas to gain insight into possible pathways for therapeutic beta cell regeneration, highligh
Externí odkaz:
https://doaj.org/article/80c3e45c47014686a61554de1f26c1c1