Zobrazeno 1 - 10 of 36 pro vyhledávání: '"Steven K Grossenbacher"'
1
Akademický článek
Bystander activation and anti-tumor effects of CD8+ T cells following Interleukin-2 based immunotherapy is independent of CD4+ T cell help.
Autor: Arta M Monjazeb, Julia K Tietze, Steven K Grossenbacher, Hui-Hua Hsiao, Anthony E Zamora, Annie Mirsoian, Brent Koehn, Bruce R Blazar, Jonathan M Weiss, Robert H Wiltrout, Gail D Sckisel, William J Murphy
Publikováno v: PLoS ONE, Vol 9, Iss 8, p e102709 (2014)
We have previously demonstrated that immunotherapy combining agonistic anti-CD40 and IL-2 (IT) results in synergistic anti-tumor effects. IT induces expansion of highly cytolytic, antigen-independent "bystander-activated" (CD8(+)CD44high) T cells dis
Externí odkaz: https://doaj.org/article/8cc561b24e474b77877ada18789ecaf1
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2
Akademický článek
Immunoediting and Antigen Loss: Overcoming the Achilles Heel of Immunotherapy with Antigen Non-Specific Therapies
Autor: Arta Monir Monjazeb, Anthony E Zamora, Steven K Grossenbacher, Annie eMirsoian, Gail D Sckisel, William J Murphy
Publikováno v: Frontiers in Oncology, Vol 3 (2013)
Cancer immunotherapy has emerged as a mainstream therapy option in the battle against cancer. Pre-clinical data demonstrates the ability of immunotherapy to harness the immune system to fight disseminated malignancy. Clinical translation has failed t
Externí odkaz: https://doaj.org/article/523307c3cfb04418a4e2b87bbb157eb6
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7
Leveraging natural killer cells for cancer immunotherapy
Autor: William J. Murphy, Ethan G. Aguilar, Steven K. Grossenbacher
Publikováno v: Immunotherapy, vol 9, iss 6
Natural killer (NK) cells are potent antitumor effector cells of the innate immune system. Based on their ability to eradicate tumors in vitro and in animal models, significant enthusiasm surrounds the prospect of leveraging human NK cells as vehicle
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bff6d51144ef6dde2fc15f959f73fe92
https://doi.org/10.2217/imt-2017-0013
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8
NK Cells Preferentially Target Tumor Cells with a Cancer Stem Cell Phenotype
Autor: Ruben C Fragoso, Arta M. Monjazeb, Robert J. Canter, William J. Murphy, Steven K. Grossenbacher, Mingyi Chen, Rachel C. Smith, Shiro Urayama, Erik Ames, Stephanie Mac, Gail D. Sckisel, Jessica Perez-Cunningham, Takeshi Hagino, Thomas J. Sayers
Publikováno v: Journal of immunology (Baltimore, Md. : 1950), vol 195, iss 8
Increasing evidence supports the hypothesis that cancer stem cells (CSCs) are resistant to antiproliferative therapies, able to repopulate tumor bulk, and seed metastasis. NK cells are able to target stem cells as shown by their ability to reject all
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::029fa9c45e76f252b3b0e058d4cd5c5b
https://doi.org/10.4049/jimmunol.1500447
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9
Radiotherapy enhances natural killer cell cytotoxicity and localization in pre-clinical canine sarcomas and first-in-dog clinical trial
Autor: Jesus I. Luna, Arta M. Monjazeb, Jennifer A. Foltz, Steven K. Grossenbacher, Robert J. Canter, William T. N. Culp, Dean A. Lee, Ian R. Sturgill, Michael S. Kent, Mingyi Chen, William J. Murphy, Jaime F. Modiano, Jiwon Sarah Park
Publikováno v: Journal for immunotherapy of cancer, vol 5, iss 1
Journal for Immunotherapy of Cancer
Canter, RJ; Grossenbacher, SK; Foltz, JA; Sturgill, IR; Park, JS; Luna, JI; et al.(2017). Radiotherapy enhances natural killer cell cytotoxicity and localization in pre-clinical canine sarcomas and first-in-dog clinical trial. Journal for ImmunoTherapy of Cancer, 5(1). doi: 10.1186/s40425-017-0305-7. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/0hj110cn
Journal for ImmunoTherapy of Cancer, Vol 5, Iss 1, Pp 1-16 (2017)
Background We have previously shown that radiotherapy (RT) augments natural killer (NK) functions in pre-clinical models of human and mouse cancers, including sarcomas. Since dogs are an excellent outbred model for immunotherapy studies, we sought to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb8e896b690c95a23a180269378e4ba
https://escholarship.org/uc/item/0hj110cn
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10
Targeting Cancer Stem Cells with Natural Killer Cell Immunotherapy
Autor: William J. Murphy, Robert J. Canter, Steven K. Grossenbacher, Jesus I. Luna
Publikováno v: Expert opinion on biological therapy, vol 17, iss 3
Luna, JI; Grossenbacher, SK; Murphy, WJ; & Canter, RJ. (2017). Targeting Cancer Stem Cells with Natural Killer Cell Immunotherapy. Expert Opinion on Biological Therapy, 17(3), 313-324. doi: 10.1080/14712598.2017.1271874. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/7bb9k7zj
© 2016 Informa UK Limited, trading as Taylor & Francis Group. Introduction: Standard cytoreductive cancer therapy, such as chemotherapy and radiotherapy, are frequently resisted by a small portion of cancer cells with ‘stem-cell’ like properties
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe4d2730c1ecd00314ea14a9d7206226
https://escholarship.org/uc/item/7bb9k7zj
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