Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Steven Julious"'
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-11 (2024)
Abstract Introduction n-of-1 trials are undertaken to optimise the evaluation of health technologies in individual patients. They involve a single patient receiving treatments, both interventional and control, consecutively over set periods of time,
Externí odkaz:
https://doaj.org/article/89a52fd62e804f53b2619e2a255f6b18
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-12 (2024)
Abstract Adverse events suffer from poor reporting within randomised controlled trials, despite them being crucial to the evaluation of a treatment. A recent update to the CONSORT harms checklist aims to improve reporting by providing structure and c
Externí odkaz:
https://doaj.org/article/fd85d3ba3c174a30841bdefa0054237f
Autor:
Olivia Hawksworth, Robin Chatters, Steven Julious, Andrew Cook, Katie Biggs, Kiera Solaiman, Michael C. H. Quah, Sxe Chang Cheong
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-10 (2024)
Abstract Background n-of-1 trials are a type of crossover trial designed to optimise the evaluation of health technologies in individual patients. This trial design may be considered for the evaluation of health technologies in rare conditions where
Externí odkaz:
https://doaj.org/article/a162f163c2544774ba2627850537937e
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/5aefca4fb2af45368679ffecb05dfaf9
Publikováno v:
Pilot and Feasibility Studies, Vol 9, Iss 1, Pp 1-11 (2023)
Abstract Background Pilot and feasibility studies provide information to be used when planning a full trial. A sufficient sample size within the pilot/feasibility study is required so this information can be extracted with suitable precision. This wo
Externí odkaz:
https://doaj.org/article/fbc31440cc8f4e5aa079963c892f3335
Autor:
Oscar Han, Hao Wei Tan, Steven Julious, Laura Sutton, Richard Jacques, Ellen Lee, Jen Lewis, Stephen Walters
Publikováno v:
BMC Medical Research Methodology, Vol 22, Iss 1, Pp 1-6 (2022)
Abstract Introduction A sample size justification is required for all studies and should give the minimum number of subjects to be recruited for the study to achieve its primary objective. The aim of this review is to describe sample sizes from agree
Externí odkaz:
https://doaj.org/article/8736a881484d4dc6b8148d999adc99f1
Autor:
Mais Iflaifel, Christopher Partlett, Jennifer Bell, Andrew Cook, Carrol Gamble, Steven Julious, Edmund Juszczak, Louise Linsell, Alan Montgomery, Kirsty Sprange
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-11 (2022)
Abstract Background Blinding is an established approach in clinical trials which aims to minimise the risk of performance and detection bias. There is little empirical evidence to guide UK clinical trials units (CTUs) about the practice of blinding s
Externí odkaz:
https://doaj.org/article/28e06c83f1774ff484e95b3403460d24
Autor:
Nikki Totton, Steven Julious, Dyfrig Hughes, Jonathan Cook, Katie Biggs, Lizzie Coates, Andrew Cook, Catherine Hewitt, Simon Day
Publikováno v:
Trials, Vol 22, Iss 1, Pp 1-5 (2021)
Abstract Background Depending on the treatment to be investigated, a clinical trial could be designed to assess objectives of superiority, equivalence or non-inferiority. The design of the study is affected by many different elements including the co
Externí odkaz:
https://doaj.org/article/ee6dba39c81b4079b6d7269a2584a159
Publikováno v:
Trials, Vol 21, Iss 1, Pp 1-12 (2020)
Abstract Introduction Adaptive designs offer a flexible approach, allowing changes to a trial based on examinations of the data as it progresses. Adaptive clinical trials are becoming a popular choice, as the prudent use of finite research budgets an
Externí odkaz:
https://doaj.org/article/d29c4f086cf34567877b6b8d172d78d5
Autor:
Brooklyn Stanley, Andrew Davis, Rupert Jones, Steven Julious, Dermot Ryan, David Jackson, David Halpin, Hilary Pinnock, Jennifer Quint, Kamlesh Khunti, Liam Heaney, Philip Oliver, Salman Siddiqui, Anu Kemppinen, Francis Appiagyei, Emma-Jane Roberts, Antony Hardjojo, Victoria Carter, Marije van Melle, David Price, Platform C19 committee
Publikováno v:
PLoS ONE, Vol 16, Iss 10, p e0258689 (2021)
BackgroundData to better understand and manage the COVID-19 pandemic is urgently needed. However, there are gaps in information stored within even the best routinely-collected electronic health records (EHR) including test results, remote consultatio
Externí odkaz:
https://doaj.org/article/786bb1c29fb64ec6819b596bdd8ef840