Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Steven Joseph Berthel"'
Autor:
H. Michael Petrassi, Gregory T. Robertson, Carl Nathan, Clifton E. Barry, Kelly Chibale, Dale J. Kempf, Helena I. Boshoff, Joël Lelièvre, Ken Duncan, Bree B. Aldridge, Jeremy M. Rock, Betsy Russell, Peter Warner, Fabian Gusovsky, Michael R. Schrimpf, Véronique Dartois, James C. Sacchettini, Nader Fotouhi, Anne J. Lenaerts, Robert H. Bates, Anna Upton, David B. Olsen, Dirk Schnappinger, David G. Russell, Case W. McNamara, David Barros-Aguirre, Tanya Parish, Kyu Y. Rhee, Philip Arthur Hipskind, Valerie Mizrahi, Paul G. Wyatt, Steven Joseph Berthel, Alexander Pym, Xin-Jie Chu, Eric J. Rubin, Ying Yuan, Christopher B. Cooper
Publikováno v:
Nature medicine. 27(8)
The Tuberculosis Drug Accelerator, an experiment designed to facilitate collaboration in tuberculosis drug discovery by breaking down barriers among competing labs and institutions, has reached a 10-year landmark. We review the consortium’s achieve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca010dc18a791b197ac73fcbf7c0f4f
https://pubmed.ncbi.nlm.nih.gov/34226736
https://pubmed.ncbi.nlm.nih.gov/34226736
Autor:
Kshitij Chhabilbhai Thakkar, Bruce L. Banner, Shiming Li, Nicholas Marcopulos, Joseph A. Sergi, Jolly Bose, Weiya Yun, Catherine Zwingelstein, Adrian Wai-Hing Cheung, Kyungjin Kim, Steven Joseph Berthel, Bingbing Wang, Lucja Orzechowski, Andrée R. Olivier
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:7518-7522
High throughput screening of the Roche compound collection led to the identification of diaminopyrroloquinazoline series as a novel class of PTP1B inhibitors. Structural modification of diaminopyrroloquinazoline series resulted in pyrido[2,3-d]pyrimi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c232213a45381b928aa7b22c684842bc
https://doi.org/10.1016/j.bmcl.2012.10.035
https://doi.org/10.1016/j.bmcl.2012.10.035
Publikováno v:
World Patent Information. 34:128-133
Nested R-groups are fundamental to patent Markush structure’s complexity, yet there have not been many recent publications in this field. We have developed a web application, called iMarVis, which provides chemists with the ability to navigate nest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8885b01430b25e7166acc3804e9d82d7
https://doi.org/10.1016/j.wpi.2012.02.002
https://doi.org/10.1016/j.wpi.2012.02.002
Publikováno v:
Journal of Chemical Information and Modeling. 51:511-520
A Markush, or generic structure, is a widely used convention in chemical and pharmaceutical patents. The flexibility and complexity of this format, however, preclude an easy understanding and analysis of chemical space. In this paper, an application
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f752971e91766e55b36623c58898f3dc
https://doi.org/10.1021/ci100261u
https://doi.org/10.1021/ci100261u
Publikováno v:
Burger's Medicinal Chemistry and Drug Discovery
This chapter includes a summary of the mechanism of action, history, and ADME properties compounds selected from four classes of marketed drugs for the treatment of type 2 diabetes. These include the biguanides (metformin), α-glucosylase inhibitors,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::087b7bcd305c5bdf3cd4bd8d3cd85075
https://doi.org/10.1002/0471266949.bmc198
https://doi.org/10.1002/0471266949.bmc198
Publikováno v:
Expert Opinion on Therapeutic Patents. 18:759-768
Background: Small molecule glucokinase activators (GKAs) represent a new strategy to treat type 2 diabetes. Glucokinase (GK) primarily exerts its effect through modulatory actions in the pancreatic...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e999320685246155adfeb44347237a28
https://doi.org/10.1517/13543776.18.7.759
https://doi.org/10.1517/13543776.18.7.759
Autor:
Gary L. Olson, Damir Vidovic, Ramakanth Sarabu, J. Hammer, Francesco Sinigaglia, Zoltan A. Nagy, Michael Steinmetz, Nicholas John Silvester Huby, Jeanmarie Guenot, Charles Belunis, Kouichi Ito, Robert K. Campbell, Paul Gillespie, David Robert Bolin, Steven Joseph Berthel, Vincent S. Madison, Fiorenza Falcioni
Publikováno v:
Nature Biotechnology. 17:562-567
We have identified a heptapeptide with high affinity to rheumatoid arthritis-associated class II major histocompatibility (MHC) molecules. Using a model of its interaction with the class II binding site, a variety of mimetic substitutions were introd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70409305cc5fff290c510e7758273981
https://doi.org/10.1038/9865
https://doi.org/10.1038/9865
Autor:
Joseph Grimsby, Wanping Geng, Navita L. Mallalieu, Mark T. Dvorozniak, Wendy Lea Corbett, Nancy-Ellen Haynes, Jagdish Kumar Racha, Yimin Qian, David J Moore, Kevin Richard Guertin, Nathan Robert Scott, Robert Francis Kester, Steven Joseph Berthel, Roumen Nikolaev Radinov, Francis A. Mennona, Ramakanth Sarabu, Duk Soon Choi, Paul Gillespie
Publikováno v:
ACS medicinal chemistry letters. 4(4)
To resolve the metabolite redox cycling associated with our earlier clinical compound 2, we carried out lead optimization of lead molecule 1. Compound 4 showed improved lipophilic ligand efficiency and demonstrated robust glucose lowering in diet-ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c20e248f7efd97a421037b2e0fbfb3ba
https://pubmed.ncbi.nlm.nih.gov/24900686
https://pubmed.ncbi.nlm.nih.gov/24900686
Autor:
Steven Joseph Berthel, Joseph Grimsby, Franz M. Matschinsky, Nicolai M. Doliba, Ramakanth Sarabu, Klaus H. Kaestner, Jane M. Vanderkooi, Bogumil Zelent
Publikováno v:
Diabetes-Perspectives in Drug Therapy ISBN: 9783642172137
Glucokinase (GK ; EC 2.7.1.1.) phosphorylates and regulates glucose metabolism in insulin-producing pancreatic beta-cells, hepatocytes, and certain cells of the endocrine and nervous systems allowing it to play a central role in glucose homeostasis .
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::187b26b1b040988126a4c0c143555ece
https://doi.org/10.1007/978-3-642-17214-4_15
https://doi.org/10.1007/978-3-642-17214-4_15
