Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Steven J. Woodhead"'
Autor:
Michelle D. Garrett, Neil T. Thompson, Paul Workman, Suzanne A. Eccles, Florence I. Raynaud, John F. Lyons, Thomas G. Davies, Steven J. Woodhead, Matthias Reule, Ruth E. Feltell, Paul S. Jones, Kathrin Heinzmann, Simon P. Heaton, Anna Zetterlund, Vanessa Martins, Alexis K. de Haven Brandon, Melanie R. Valenti, Paul D. Eve, Robert H. te Poele, Kyla M. Grimshaw, Mike I. Walton, Timothy A. Yap
PDF file - 81K, Supplementary data comprising the materials and methods for (i) crystallography (ii) gene expression studies (iii) siRNA studies and Supplementary Figure legends 1-7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136ef480c6dff64c10335140171ee9da
https://doi.org/10.1158/1078-0432.22446023.v1
https://doi.org/10.1158/1078-0432.22446023.v1
Autor:
Michelle D. Garrett, Neil T. Thompson, Paul Workman, Suzanne A. Eccles, Florence I. Raynaud, John F. Lyons, Thomas G. Davies, Steven J. Woodhead, Matthias Reule, Ruth E. Feltell, Paul S. Jones, Kathrin Heinzmann, Simon P. Heaton, Anna Zetterlund, Vanessa Martins, Alexis K. de Haven Brandon, Melanie R. Valenti, Paul D. Eve, Robert H. te Poele, Kyla M. Grimshaw, Mike I. Walton, Timothy A. Yap
XLS file - 703K, Gene expression data for CCT128930: Genes that showed at least a 1.5 Fold Change in at least one treated sample compared to vehicle control and were differentially expressed between the treatment groups (Welch ANOVA FDR5%)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::264e5ae7347bb9dfece9541b75115729
https://doi.org/10.1158/1078-0432.22446017.v1
https://doi.org/10.1158/1078-0432.22446017.v1
Autor:
Michelle D. Garrett, Neil T. Thompson, Paul Workman, Suzanne A. Eccles, Florence I. Raynaud, John F. Lyons, Thomas G. Davies, Steven J. Woodhead, Matthias Reule, Ruth E. Feltell, Paul S. Jones, Kathrin Heinzmann, Simon P. Heaton, Anna Zetterlund, Vanessa Martins, Alexis K. de Haven Brandon, Melanie R. Valenti, Paul D. Eve, Robert H. te Poele, Kyla M. Grimshaw, Mike I. Walton, Timothy A. Yap
Purpose: Deregulated phosphatidylinositol 3-kinase pathway signaling through AGC kinases including AKT, p70S6 kinase, PKA, SGK and Rho kinase is a key driver of multiple cancers. The simultaneous inhibition of multiple AGC kinases may increase antitu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73dad559501b49bb682286db9d7d443d
https://doi.org/10.1158/1078-0432.c.6520622
https://doi.org/10.1158/1078-0432.c.6520622
Autor:
Michelle D. Garrett, Neil T. Thompson, Paul Workman, Suzanne A. Eccles, Florence I. Raynaud, John F. Lyons, Thomas G. Davies, Steven J. Woodhead, Matthias Reule, Ruth E. Feltell, Paul S. Jones, Kathrin Heinzmann, Simon P. Heaton, Anna Zetterlund, Vanessa Martins, Alexis K. de Haven Brandon, Melanie R. Valenti, Paul D. Eve, Robert H. te Poele, Kyla M. Grimshaw, Mike I. Walton, Timothy A. Yap
XLS file - 66K, Genes that showed at least a 1.5 Fold Change in at least one treated sample compared to vehicle control and were differentially expressed between the treatment groups (Welch ANOVA FDR5%) for both CCT128930 and AT13148
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02505457843f17ab3c7bd679c87ef577
https://doi.org/10.1158/1078-0432.22446008
https://doi.org/10.1158/1078-0432.22446008
Autor:
Michelle D. Garrett, Neil T. Thompson, Paul Workman, Suzanne A. Eccles, Florence I. Raynaud, John F. Lyons, Thomas G. Davies, Steven J. Woodhead, Matthias Reule, Ruth E. Feltell, Paul S. Jones, Kathrin Heinzmann, Simon P. Heaton, Anna Zetterlund, Vanessa Martins, Alexis K. de Haven Brandon, Melanie R. Valenti, Paul D. Eve, Robert H. te Poele, Kyla M. Grimshaw, Mike I. Walton, Timothy A. Yap
PDF file - 553K, Supplementary Figure 1. Phosphorylation of AKT substrates remains suppressed, despite pSer473 AKT induction. Supplementary Figure 2. The pharmacokinetic-pharmacodynamic profile and antitumor activity of AT13148 in PTEN-deficient PC3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66309a130e6558ca6307e2e123bca36e
https://doi.org/10.1158/1078-0432.22446026
https://doi.org/10.1158/1078-0432.22446026
Publikováno v:
Chemical Society Reviews. 31:43-59
Plant extracts of the Celastraceae have been used for centuries throughout South America and China as insect repellents and insecticides in traditional agriculture, and also for the treatment of a plethora of medical ailments from stomach complaints
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1324872fb7c47c4ae943908a527abb88
https://doi.org/10.1039/b000678p
https://doi.org/10.1039/b000678p
Autor:
Matthew Weston, Steven J. Woodhead, Matthew J. Webber, Alexander Alanine, Lyn Powell, Andrew J. P. White, Stacy Clark, Jeffrey P. Stonehouse, Alan C. Spivey, Stephen Stokes, Christopher S. Frampton, Sarah A. Warren, Damian M. Grainger
Publikováno v:
Organicbiomolecular chemistry. 11(15)
The development of a stereoselective total synthesis of β-dihydroagarofuran 4 is described. This compound contains the same oxygenation pattern on its ‘lower-rim’ as found in the natural sesquiterpene (−)-euonyminol (1) and it is expected that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b8beb18d78a14796ab2791596d58548
https://pubmed.ncbi.nlm.nih.gov/23443742
https://pubmed.ncbi.nlm.nih.gov/23443742
Publikováno v:
Angewandte Chemie. 113:791-793
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12420cf156e8e583d98815e8eae1ae85
https://doi.org/10.1002/1521-3757(20010216)113:4<791::aid-ange7910>3.0.co
https://doi.org/10.1002/1521-3757(20010216)113:4<791::aid-ange7910>3.0.co
Publikováno v:
Angewandte Chemie International Edition. 40:769-771
Crude plant extracts of the Celastraceae have been valued since antiquity for their stimulant, appetite suppressive, antiarthritic, antibacterial, insect repellent, and memoryrestorative properties.[1] Pervasive among the secondary metabolites isolat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5b2b84d920bb7668b9dc109eb30414c
https://doi.org/10.1002/1521-3773(20010216)40:4<769::aid-anie7690>3.0.co
https://doi.org/10.1002/1521-3773(20010216)40:4<769::aid-anie7690>3.0.co
Autor:
Alan C. Spivey, Steven J. Woodhead
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cae9ea98c3381b324cd5c8924b342f2
https://doi.org/10.1002/chin.199916290
https://doi.org/10.1002/chin.199916290