Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Steven J. Tuske"'
Autor:
Stephen J. Coales, Anita Liu, Sook Yen E, Jessica E. Lee, Deepangi Pandit, Jeffrey A. Morrow, Yoshitomo Hamuro, Jennifer F. Nemeth, Steven J. Tuske
Publikováno v:
Journal of Molecular Recognition. 25:114-124
Understanding antigen-antibody interactions at the sub-molecular level is of particular interest for scientific, regulatory, and intellectual property reasons, especially with increasing demand for monoclonal antibody therapeutic agents. Although var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ce2b2c1518c760214066a96254361d5
https://doi.org/10.1002/jmr.1169
https://doi.org/10.1002/jmr.1169
Publikováno v:
Rapid Communications in Mass Spectrometry. 23:639-647
The epitope of horse cytochrome c against monoclonal antibody E8 was determined using amide hydrogen/deuterium (H/D) exchange combined with immobilized antibody, on-line pepsin proteolysis, liquid chromatography (LC), and mass spectrometry (MS). The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2acf3fe8ab0ef8bb7a7684557fb198c
https://doi.org/10.1002/rcm.3921
https://doi.org/10.1002/rcm.3921
Autor:
Yoshitomo Hamuro, Brigitte Rigat, Stephen J. Coales, Michael B. Tropak, Eric D. Brown, Don J. Mahuran, Gustavo Maegawa, Justin D. Buttner, Cecilia Murphy, G. Kornhaber, Steven J. Tuske, Jan E. Blanchard
Publikováno v:
ChemBioChem. 9:2650-2662
Point mutations in beta-glucocerebrosidase (GCase) can result in a deficiency of both GCase activity and protein in lysosomes thereby causing Gaucher Disease (GD). Enzyme inhibitors such as isofagomine, acting as pharmacological chaperones (PCs), inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a927cd89c75478a8487aee1b78cb41a
https://doi.org/10.1002/cbic.200800304
https://doi.org/10.1002/cbic.200800304
Autor:
Deepangi, Pandit, Steven J, Tuske, Stephen J, Coales, Sook Yen, E, Anita, Liu, Jessica E, Lee, Jeffrey A, Morrow, Jennifer F, Nemeth, Yoshitomo, Hamuro
Publikováno v:
Journal of molecular recognition : JMR. 25(3)
Understanding antigen-antibody interactions at the sub-molecular level is of particular interest for scientific, regulatory, and intellectual property reasons, especially with increasing demand for monoclonal antibody therapeutic agents. Although var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::33bfdbc0d03da85936db724ab57b27bb
https://pubmed.ncbi.nlm.nih.gov/22407975
https://pubmed.ncbi.nlm.nih.gov/22407975
Autor:
Gerald Beste, Trevor Wilkinson, David J. Hargreaves, Steven J. Tuske, Bojana Popovic, Stefan Gerhardt, Richard A. Pauptit, Gareth Rees, Sarah Bishop, Wendy Barker, Melanie Snow, Maurice Needham, Tris Vaugan, Matthew A. Sleeman, Caroline Russell, Rick Davies, Azad Aziz, Sarah Dawson, Fraser Welsh, W. Mark Abbott, Stephen J. Coales, Yoshitomo Hamuro, Caroline Langham
Publikováno v:
Journal of molecular biology. 394(5)
IL-17A is a pro-inflammatory cytokine produced by the newly identified Th17 subset of T-cells. We have isolated a human monoclonal antibody to IL-17A (CAT-2200) that can potently neutralize the effects of recombinant and native human IL-17A. We deter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c4bc5c35006c195c84086b1ffc5a23
https://pubmed.ncbi.nlm.nih.gov/19835883
https://pubmed.ncbi.nlm.nih.gov/19835883
Autor:
Steven J. Tuske, Yoshitomo Hamuro, G. Kornhaber, Don J. Mahuran, Gustavo Maegawa, Stephen J. Coales, Michael B. Tropak
Publikováno v:
Chembiochem : a European journal of chemical biology. 9(16)
Structurally destabilizing mutations in acid beta-glucosidase (GCase) can result in Gaucher disease (GD). The iminosugar isofagomine (IFG), a competitive inhibitor and a potential pharmacological chaperone of GCase, is currently undergoing clinical e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa64862c77517a6afe5648855fb572a
https://pubmed.ncbi.nlm.nih.gov/18932186
https://pubmed.ncbi.nlm.nih.gov/18932186
Publikováno v:
Rapid communications in mass spectrometry : RCM. 22(7)
Statistical analysis of data from 39 proteins (13 766 amino acid residues) digested with immobilized porcine pepsin under conditions compatible with hydrogen/deuterium (H/D) exchange (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fff48007686836c22c568477bbc1d912
https://pubmed.ncbi.nlm.nih.gov/18327892
https://pubmed.ncbi.nlm.nih.gov/18327892
Autor:
Mark R. Southern, Patrick R. Griffin, Yoshitomo Hamuro, Jeffrey A. Morrow, Stephen J. Coales, Steven J. Tuske, Kathleen S. Molnar
Publikováno v:
Protein science : a publication of the Protein Society. 15(8)
A nuclear receptor, peroxisome proliferator-activated receptor gamma (PPARgamma), is a ligand-dependent transcription factor involved in glucose homeostasis and adipocyte differentiation. PPARgamma is the molecular target of various natural and synth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7669411215fb6c5a2215f8238a9eb75
https://pubmed.ncbi.nlm.nih.gov/16823031
https://pubmed.ncbi.nlm.nih.gov/16823031
Autor:
Cecilia Murphy, Yoshitomo Hamuro, Michael B. Tropak, Don J. Mahuran, G. Kornhaber, Steven J. Tuske, Jan E. Blanchard, Gustavo Maegawa, Eric D. Brown, Justin D. Buttner, Brigitte Rigat, Stephen J. Coales
Publikováno v:
ChemBioChem. 9:2549-2549
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f01b934ee02db8e8566def001226af3
https://doi.org/10.1002/cbic.200890061
https://doi.org/10.1002/cbic.200890061
Autor:
Tropak, Michael B., Kornhaber, Gregory J., Rigat, Brigitte A., Maegawa, Gustavo H., Buttner, Justin D., Blanchard, Jan E., Murphy, Cecilia, Tuske, Steven J., Coales, Stephen J., Hamuro, Yoshitomo, Brown, Eric D., Mahuran, Don J.
Publikováno v:
ChemBioChem; Nov2008, Vol. 9 Issue 16, p2549-2549, 2p