Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Steven J. Traylor"'
Autor:
Soumitra Bhoyar, Max Foster, Young Hoon Oh, Xuankuo Xu, Steven J. Traylor, Jing Guo, Sanchayita Ghose, Abraham M. Lenhoff
Publikováno v:
Journal of Chromatography A. 1696:463962
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdd72fd6f40b213fa2ca220719beb872
https://doi.org/10.1016/j.chroma.2023.463962
https://doi.org/10.1016/j.chroma.2023.463962
Autor:
Xuankuo Xu, Nripen Singh, Zheng Jian Li, Steven J. Traylor, Ohnmar Khanal, Abraham M. Lenhoff, Sanchayita Ghose, Chao Huang
Publikováno v:
Journal of Membrane Science. :464-471
Depth filtration is a commonly-used bioprocessing unit operation for harvest clarification that reduces the levels of process- and product-related impurities such as cell debris, host-cell proteins, nucleic acids and protein aggregates. Since depth f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3348f85c44f9d2090fcb2f020c138f1
https://doi.org/10.1016/j.memsci.2018.10.058
https://doi.org/10.1016/j.memsci.2018.10.058
Autor:
Chase E. Herman, Xuankuo Xu, Steven J. Traylor, Sanchayita Ghose, Zheng Jian Li, Abraham M. Lenhoff
Publikováno v:
Journal of Chromatography A. 1664:462788
Flow-through ion-exchange chromatography is frequently used in polishing biotherapeutics, but the factors that contribute to impurity persistence are incompletely understood. A large number of dilute impurities may be encountered that exhibit physico
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c46799f60bd383536bc5915b5e4466a2
https://doi.org/10.1016/j.chroma.2021.462788
https://doi.org/10.1016/j.chroma.2021.462788
Publikováno v:
Biotechnology and Bioengineering. 115:423-432
Protein A chromatography has been identified as a potential bottleneck in the monoclonal antibody production platform, leading to increased interest in non-chromatographic capture technologies. Affinity precipitation using environmentally responsive,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25abd628a879e9d0ef68b0dc18ca52dc
https://doi.org/10.1002/bit.26467
https://doi.org/10.1002/bit.26467
Autor:
Fnu Namila, Tung Nguyen, Ranil Wickramasinghe, Steven J. Traylor, Da Zhang, Xianghong Qian, Nripen Singh
Publikováno v:
Biotechnology and bioengineering. 116(10)
A combined pore blockage and cake filtration model was applied to the virus filtration of an Fc-fusion protein using the three commercially available filters, F-1, F-2, and F-3 in a range of buffer conditions including sodium-phosphate and tris-aceta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::915299c046bf31323b087822b0e5df3d
https://pubmed.ncbi.nlm.nih.gov/31184371
https://pubmed.ncbi.nlm.nih.gov/31184371
Autor:
Steven J. Traylor, Zheng Jian Li, Xuankuo Xu, Ohnmar Khanal, Sanchayita Ghose, Nripen Singh, Abraham M. Lenhoff
Publikováno v:
Biotechnology and bioengineering. 115(8)
Depth filtration is widely used in downstream bioprocessing to remove particulate contaminants via depth straining and is therefore applied to harvest clarification and other processing steps. However, depth filtration also removes proteins via adsor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4796492152e366c53c9ad970cc804c7
https://pubmed.ncbi.nlm.nih.gov/29663326
https://pubmed.ncbi.nlm.nih.gov/29663326
Autor:
Zheng Jian Li, Norman J. Wagner, Sanchayita Ghose, Jing Guo, Xuankuo Xu, Nripen Singh, Kelvin H. Lee, Abraham M. Lenhoff, Leila H. Choe, Steven J. Traylor, Lye Lin Lock, Shannon Modla, Daniel G. Greene
Publikováno v:
Biotechnology and Bioengineering
Protein precipitates that arise during bioprocessing can cause manufacturing challenges, but they can also aid in clearance of host-cell protein (HCP) and DNA impurities. Such precipitates differ from many protein precipitates that have been studied
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d42f3b45f3b35a8e0cc3ecbfac4fdfa8
Publikováno v:
Chemical Engineering & Technology. 35:91-101
A diverse array of experimental techniques was used to compare protein sorption and transport on agarose-based resins with and without dextran extenders. Van 't Hoff plots indicated similar trends for lysozyme on the resins, with enthalpically domina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::053a5a1babb50246bf86ad3cf179b7d6
https://doi.org/10.1002/ceat.201100304
https://doi.org/10.1002/ceat.201100304
Autor:
Anthony P. Ammirati, Steven M. Timmick, Steven J. Traylor, Brian D. Bowes, Abraham M. Lenhoff
Publikováno v:
Journal of chromatography. A. 1340
A fully-mechanistic understanding of protein transport and sorption in chromatographic materials has remained elusive despite the application of modern continuum and molecular observation techniques. While measuring overall uptake rates in proteins i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1375f2cd14492d010ed0e0c72cbf2be9
https://pubmed.ncbi.nlm.nih.gov/24685162
https://pubmed.ncbi.nlm.nih.gov/24685162
Publikováno v:
Journal of chromatography. A. 1218(16)
Most chromatographic processes involve separation of two or more species, so development of a simple, accurate multicomponent chromatographic model can be valuable for improving process efficiency and yield. We consider the case of breakthrough chrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::554aaf0f3ed216f9fddc9e0d4ea43521
https://pubmed.ncbi.nlm.nih.gov/21411102
https://pubmed.ncbi.nlm.nih.gov/21411102