Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Steven J. Schrodi"'
Publikováno v:
Heliyon, Vol 10, Iss 11, Pp e32053- (2024)
With the recent expansion of structural variant identification in the human genome, understanding the role of these impactful variants in disease architecture is critically important. Currently, a large proportion of genome-wide-significant genome-wi
Externí odkaz:
https://doaj.org/article/7b69eb1475c1425d8d889d9bb6f2d8bd
Autor:
Kelsey M. Haas, Michael J. McGregor, Mehdi Bouhaddou, Benjamin J. Polacco, Eun-Young Kim, Thong T. Nguyen, Billy W. Newton, Matthew Urbanowski, Heejin Kim, Michael A. P. Williams, Veronica V. Rezelj, Alexandra Hardy, Andrea Fossati, Erica J. Stevenson, Ellie Sukerman, Tiffany Kim, Sudhir Penugonda, Elena Moreno, Hannes Braberg, Yuan Zhou, Giorgi Metreveli, Bhavya Harjai, Tia A. Tummino, James E. Melnyk, Margaret Soucheray, Jyoti Batra, Lars Pache, Laura Martin-Sancho, Jared Carlson-Stevermer, Alexander S. Jureka, Christopher F. Basler, Kevan M. Shokat, Brian K. Shoichet, Leah P. Shriver, Jeffrey R. Johnson, Megan L. Shaw, Sumit K. Chanda, Dan M. Roden, Tonia C. Carter, Leah C. Kottyan, Rex L. Chisholm, Jennifer A. Pacheco, Maureen E. Smith, Steven J. Schrodi, Randy A. Albrecht, Marco Vignuzzi, Lorena Zuliani-Alvarez, Danielle L. Swaney, Manon Eckhardt, Steven M. Wolinsky, Kris M. White, Judd F. Hultquist, Robyn M. Kaake, Adolfo García-Sastre, Nevan J. Krogan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-27 (2023)
Abstract Influenza A Virus (IAV) is a recurring respiratory virus with limited availability of antiviral therapies. Understanding host proteins essential for IAV infection can identify targets for alternative host-directed therapies (HDTs). Using aff
Externí odkaz:
https://doaj.org/article/6403bbe7a8b6480aacd27d46627e36f2
Autor:
Feifan Zhang, Xin Zhang, Haikun Zhang, Dongdong Lin, Hailang Fan, Shicheng Guo, Fang An, Yaqian Zhao, Jun Li, Steven J. Schrodi, Dake Zhang
Publikováno v:
Epigenetics, Vol 18, Iss 1 (2023)
DNA methylation (DNAme) alterations are known to initiate from the precancerous stage of tumorigenesis. Herein, we investigated the global and local patterns of DNAme perturbations in tumorigenesis by analysing the genome-wide DNAme profiles of the c
Externí odkaz:
https://doaj.org/article/347d015a23a249e09db6c25d8c27afa7
Autor:
Xiaoyan Li, Hailang Fan, Xiantao Song, Bangrong Song, Wenxian Liu, Ran Dong, Haikun Zhang, Shicheng Guo, Hao Liang, Steven J. Schrodi, Xuebin Fu, Sunjay Kaushal, Yanlong Ren, Dake Zhang
Publikováno v:
Epigenetics, Vol 18, Iss 1 (2023)
Hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease. However, a detailed DNA methylation (DNAme) landscape has not yet been elucidated. Our study combined DNAme and transcriptome profiles for HCM myocardium and identify aberr
Externí odkaz:
https://doaj.org/article/b19dc6c172ab42939e9337cc2b14a3f3
Autor:
Jianan Zhao, Kai Wei, Yiming Shi, Ping Jiang, Lingxia Xu, Cen Chang, Linshuai Xu, Yixin Zheng, Yu Shan, Jia Liu, Li Li, Shicheng Guo, Steven J. Schrodi, Rongsheng Wang, Dongyi He
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Objective: To investigate the potential association between Anoikis-related genes, which are responsible for preventing abnormal cellular proliferation, and rheumatoid arthritis (RA).Methods: Datasets GSE89408, GSE198520, and GSE97165 were obtained f
Externí odkaz:
https://doaj.org/article/81442de10ea8486985e5fb5e045128ab
Autor:
Yixin Zheng, Jianan Zhao, Mi Zhou, Kai Wei, Ping Jiang, Lingxia Xu, Cen Chang, Yu Shan, Linshuai Xu, Yiming Shi, Steven J. Schrodi, Shicheng Guo, Dongyi He
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and joint damage. The signaling lymphocytic activation molecule (SLAMF) family of receptors are expressed on various hematopoietic and non-hematopoietic cells an
Externí odkaz:
https://doaj.org/article/db04b390b7e84ad28f7a350b2bde60b1
Autor:
Yu Shan, Jianan Zhao, Kai Wei, Ping Jiang, Lingxia Xu, Cen Chang, Linshuai Xu, Yiming Shi, Yixin Zheng, Yanqin Bian, Mi Zhou, Steven J. Schrodi, Shicheng Guo, Dongyi He
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Rheumatic and autoimmune diseases are a group of immune system-related disorders wherein the immune system mistakenly attacks and damages the body’s tissues and organs. This excessive immune response leads to inflammation, tissue damage, and functi
Externí odkaz:
https://doaj.org/article/2ac8559555dc4376937a1923b8c8b5de
Publikováno v:
Cellular & Molecular Biology Letters, Vol 27, Iss 1, Pp 1-14 (2022)
Abstract Absent in melanoma 2 (AIM2), a member of the Pyrin and HIN domain protein family, is a cytoplasmic receptor that recognizes double-stranded DNA. AIM2 exhibits limited expression under physiological conditions but is widely expressed in many
Externí odkaz:
https://doaj.org/article/e49667969562442ea8288b0d4e19244e
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Rheumatoid arthritis (RA) is a complex autoimmune disease characterized by chronic inflammation that affects synovial tissues of multiple joints. Granzymes (Gzms) are serine proteases that are released into the immune synapse between cytotoxic lympho
Externí odkaz:
https://doaj.org/article/de118b7298ef4a44aab807db54941d8b
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Rheumatoid arthritis (RA) is a highly disabling chronic autoimmune disease. Multiple factors contribute to the complex pathological process of RA, in which an abnormal autoimmune response, high survival of inflammatory cells, and excessive release of
Externí odkaz:
https://doaj.org/article/5c799dbac9e047168accc8f773884baa