Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Steven J. R. Twiddle"'
Publikováno v:
Organic Process Research & Development. 17:193-201
Tertiary carbinamine 5 is an isolated intermediate in the synthesis of a novel, inhaled β-2 adrenoreceptor agonist PF-610355. Process development for the key amide-formation and Ritter reactions, together with reaction understanding studies are disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff6ef98f8ca6e404d83b12bb608d3ee1
https://doi.org/10.1021/op300341n
https://doi.org/10.1021/op300341n
Autor:
Stéphane Content, Thomas Dupont, Nicolas M. Fédou, Radoslav Penchev, Julian D. Smith, Flavien Susanne, Christopher Stoneley, Steven J. R. Twiddle
Publikováno v:
Organic Process Research & Development. 17:202-212
PF-610355 is a novel inhaled β-2 adrenoreceptor agonist. Process development of the final intermediate and the API are discussed with emphasis on the control of physical properties and subsequent i...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07da42fe99aa526dad4c9b561279821b
https://doi.org/10.1021/op300342y
https://doi.org/10.1021/op300342y
Publikováno v:
Tetrahedron Letters. 52:1277-1280
The one-pot Darzens condensation of α,β-unsaturated aldehydes and ketones with enolates of an α-bromo ester or ketone is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3213e3f1cbca5207152466e199db5055
https://doi.org/10.1016/j.tetlet.2011.01.046
https://doi.org/10.1016/j.tetlet.2011.01.046
Autor:
Steven J. R. Twiddle, Andrew P. Lightfoot, Andrew Whiting, Judith A. K. Howard, Andrei S. Batsanov
Publikováno v:
European Journal of Organic Chemistry. 2005:1876-1883
A novel class of charge-transfer complexes based on iodine chloride and substituted pyridines, which possess a number of interesting and unique structural features, can be employed to bring about a stereocontrolled chloro-deboronation of certain viny
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d595cee3c9437f0279daa22f1063fcac
https://doi.org/10.1002/ejoc.200400855
https://doi.org/10.1002/ejoc.200400855
Publikováno v:
Tetrahedron Letters. 45:8557-8561
Conversion of hindered alkenyl boronate esters into the corresponding iodoalkene, or alkenyl chloride can be carried out stereoselectively using ICl. In the presence of NaOMe, direct reaction of ICl is favoured yielding the E -iodoalkene, however, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f571ca4fd6a162072cca8820a94ba37
https://doi.org/10.1016/j.tetlet.2004.09.096
https://doi.org/10.1016/j.tetlet.2004.09.096
Publikováno v:
Synlett. :529-531
An extremely simple and efficient palladium-catalyzed coupling procedure for the synthesis of functionalized styrenes and dienes is utilized to demonstrate how 4,4,6-trimethyl-2-vinyl-1,3,2-dioxaborinane can be employed to selectively undergo Suzuki-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff71e3483edeef95f254c5a5923e4af
https://doi.org/10.1055/s-2005-862354
https://doi.org/10.1055/s-2005-862354
Publikováno v:
ChemInform. 42
Enolates of α-bromo esters (I) or ketones (V) undergo one-pot Darzens condensation to give diastereomeric mixtures of epoxides.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c5cc27bd861895cca77e88681ba3f5c
https://doi.org/10.1002/chin.201123088
https://doi.org/10.1002/chin.201123088
Autor:
Carl Thirsk, Andrei S. Batsanov, and Steven J. R. Twiddle, Andrew P. Lightfoot, Jonathan P. Knowles, Andrew Whiting, Maw Graham Nigel
Publikováno v:
Organic letters. 9(26)
A strategy has been developed for a rapid seven-step construction of a chiral, nonracemic vinyl cyclopentanone building block as part of a synthetic approach to viridenomycin, using a diastereo- and enantioselective Mukaiyama aldol and intramolecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc2832680ef50d2019601b04778bef72
https://pubmed.ncbi.nlm.nih.gov/18020354
https://pubmed.ncbi.nlm.nih.gov/18020354
Publikováno v:
ResearcherID
A number of 1,6-diphenyl-1,3,5-hexatrienes of varying alkene geometries were stereoselectively prepared from just two starting materials: iodobenzene and 4,4,6-trimethyl-2-vinyl-1,3,2-dioxaborinane via a series of Heck, Suzuki-Miyaura and stereocontr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e09b2de26ebd0aedb040f7a97f107273
https://pubmed.ncbi.nlm.nih.gov/16106297
https://pubmed.ncbi.nlm.nih.gov/16106297
Publikováno v:
ChemInform. 35
4,4,6-Trimethyl-2-vinyl-1,3,2-dioxaborinane is a superior reagent in terms of stability and reactivity in comparison to the vinylboronate pinacol ester, giving improved selectivity for Heck versus Suzuki coupling with both aryl iodides and bromides,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed12bb16b85b159316badbd5fcb1f474
https://doi.org/10.1002/chin.200402172
https://doi.org/10.1002/chin.200402172