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pro vyhledávání: '"Steven J. Kolvek"'
Autor:
Asuncion Martinez, Kara Brown, Ian Macneil, Marcia S. Osburne, Choi Lai Tiong Yip, Joern Hopke, Steven J. Kolvek
Publikováno v:
Applied and Environmental Microbiology. 70:2452-2463
The enormous diversity of uncultured microorganisms in soil and other environments provides a potentially rich source of novel natural products, which is critically important for drug discovery efforts. Our investigators reported previously on the cr
Autor:
Asuncion Martinez, Joern Hopke, Philippe Normand, Pascale Jeannin, Michel Guerineau, Renaud Nalin, Jean-Luc Pernodet, Paul R. August, Marcia S. Osburne, François Francou, Steven J. Kolvek, Pascal Simonet, Maria M. Ball, Sophie Courtois, Gerard Helynck, Carmela Cappellano
Publikováno v:
Applied and Environmental Microbiology
Applied and Environmental Microbiology, American Society for Microbiology, 2003, 69 (1), pp.49-55. ⟨10.1128/AEM.69.1.49-55.2003⟩
Applied and Environmental Microbiology, American Society for Microbiology, 2003, 69 (1), pp.49-55. ⟨10.1128/AEM.69.1.49-55.2003⟩
To further explore possible avenues for accessing microbial biodiversity for drug discovery from natural products, we constructed and screened a 5,000-clone “shotgun” environmental DNA library by using an Escherichia coli-Streptomyces lividans sh
Publikováno v:
Applied and environmental microbiology. 71(3)
Here we describe the rep gene, isolated from an environmental DNA library, which when transformed into Streptomyces species resulted in increased production of secondary metabolites and accelerated sporulation. We show that Streptomyces lividans stra