Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Steven J. Hancock"'
Autor:
Nguyen Thi Khanh Nhu, M. Arifur Rahman, Kelvin G. K. Goh, Seung Jae Kim, Minh-Duy Phan, Kate M. Peters, Laura Alvarez-Fraga, Steven J. Hancock, Chitra Ravi, Timothy J. Kidd, Matthew J. Sullivan, Katharine M. Irvine, Scott A. Beatson, Matthew J. Sweet, Adam D. Irwin, Jana Vukovic, Glen C. Ulett, Sumaira Z. Hasnain, Mark A. Schembri
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Bacteria adapt to selective pressure in their immediate environment in multiple ways. One mechanism involves the acquisition of independent mutations that disable or modify a key pathway, providing a signature of adaptation via convergent ev
Externí odkaz:
https://doaj.org/article/0c835c379e9d49008c3aba49b38fd4c2
Autor:
Andre Mu, William P. Klare, Sarah L. Baines, C. N. Ignatius Pang, Romain Guérillot, Nichaela Harbison-Price, Nadia Keller, Jonathan Wilksch, Nguyen Thi Khanh Nhu, Minh-Duy Phan, Bernhard Keller, Brunda Nijagal, Dedreia Tull, Saravanan Dayalan, Hwa Huat Charlie Chua, Dominik Skoneczny, Jason Koval, Abderrahman Hachani, Anup D. Shah, Nitika Neha, Snehal Jadhav, Sally R. Partridge, Amanda J. Cork, Kate Peters, Olivia Bertolla, Stephan Brouwer, Steven J. Hancock, Laura Álvarez-Fraga, David M. P. De Oliveira, Brian Forde, Ashleigh Dale, Warasinee Mujchariyakul, Calum J. Walsh, Ian Monk, Anna Fitzgerald, Mabel Lum, Carolina Correa-Ospina, Piklu Roy Chowdhury, Robert G. Parton, James De Voss, James Beckett, Francois Monty, Jessica McKinnon, Xiaomin Song, John R. Stephen, Marie Everest, Matt I. Bellgard, Matthew Tinning, Michael Leeming, Dianna Hocking, Leila Jebeli, Nancy Wang, Nouri Ben Zakour, Serhat A. Yasar, Stefano Vecchiarelli, Tonia Russell, Thiri Zaw, Tyrone Chen, Don Teng, Zena Kassir, Trevor Lithgow, Adam Jenney, Jason N. Cole, Victor Nizet, Tania C. Sorrell, Anton Y. Peleg, David L. Paterson, Scott A. Beatson, Jemma Wu, Mark P. Molloy, Anna E. Syme, Robert J. A. Goode, Adam A. Hunter, Grahame Bowland, Nicholas P. West, Marc R. Wilkins, Steven P. Djordjevic, Mark R. Davies, Torsten Seemann, Benjamin P. Howden, Dana Pascovici, Sonika Tyagi, Ralf B. Schittenhelm, David P. De Souza, Malcolm J. McConville, Jonathan R. Iredell, Stuart J. Cordwell, Richard A. Strugnell, Timothy P. Stinear, Mark A. Schembri, Mark J. Walker
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Severe sepsis has a high mortality rate. Here, the authors provide genomic, transcriptomic, proteomic and metabolomic data across four sepsis-causing pathogens and identify a signature of global increase in fatty acid and lipid biosynthesis as well a
Externí odkaz:
https://doaj.org/article/6d65b18b91de403488fe5eca204df6be
Autor:
Zheng Jie Lian, Minh-Duy Phan, Steven J. Hancock, Nguyen Thi Khanh Nhu, David L. Paterson, Mark A. Schembri
Publikováno v:
PLoS Genetics, Vol 19, Iss 6 (2023)
Plasmids are major drivers of increasing antibiotic resistance, necessitating an urgent need to understand their biology. Here we describe a detailed dissection of the molecular components controlling the genetics of I-complex plasmids, a group of an
Externí odkaz:
https://doaj.org/article/1ac6e8a83b4a4fc9a619b53cc473b128
Autor:
Ricardo Calderon-Gonzalez, Alix Lee, Guillermo Lopez-Campos, Steven J. Hancock, Joana Sa-Pessoa, Amy Dumigan, Ronan McMullan, Eric L. Campbell, Jose A. Bengoechea
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT Klebsiella pneumoniae is a leading cause of nosocomial and community acquired infections, making K. pneumoniae the pathogen that is associated with the second largest number of deaths attributed to any antibiotic resistant infection. K. pneu
Externí odkaz:
https://doaj.org/article/8d74ee6a8a224fe895fcd318972ecd86
Autor:
Julieanne L. Vo, Gabriela C. Martínez Ortiz, Makrina Totsika, Alvin W. Lo, Steven J. Hancock, Andrew E. Whitten, Lilian Hor, Kate M. Peters, Valentin Ageorges, Nelly Caccia, Mickaël Desvaux, Mark A. Schembri, Jason J. Paxman, Begoña Heras
Publikováno v:
npj Biofilms and Microbiomes, Vol 8, Iss 1, Pp 1-12 (2022)
Abstract The formation of aggregates and biofilms enhances bacterial colonisation and infection progression by affording protection from antibiotics and host immune factors. Despite these advantages there is a trade-off, whereby bacterial disseminati
Externí odkaz:
https://doaj.org/article/349e75192df143f99a4bfd28d161e466
Autor:
Laura Alvarez-Fraga, Minh-Duy Phan, Kelvin G. K. Goh, Nguyen Thi Khanh Nhu, Steven J. Hancock, Luke P. Allsopp, Kate M. Peters, Brian M. Forde, Leah W. Roberts, Matthew J. Sullivan, Makrina Totsika, Scott A. Beatson, Glen C. Ulett, Mark A. Schembri
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT Many antibiotic resistant uropathogenic Escherichia coli (UPEC) strains belong to clones defined by their multilocus sequence type (ST), with ST131 being the most dominant. Although we have a good understanding of resistance development to f
Externí odkaz:
https://doaj.org/article/604971ebb7e74b8980f09a7b03594636
Publikováno v:
mSphere, Vol 4, Iss 4 (2019)
ABSTRACT Proteins secreted by the type V secretion system possess multiple functions, including the capacity to mediate adhesion, aggregation, and biolfilm formation. The type V secretion system can be divided into five subclasses, one of which is th
Externí odkaz:
https://doaj.org/article/5a2bce43cc6740758735a697a788792f
Autor:
Ricardo Calderon-Gonzalez, Alix Lee, Guillermo Lopez-Campos, Steven J. Hancock, Joana Sa-Pessoa, Amy Dumigan, Ronan McMullan, Eric L. Campbell, Jose A. Bengoechea
Klebsiella pneumoniae is a leading cause of nosocomial and community acquired infections, making K. pneumoniae the second pathogen associated with the most deaths attributed to any antibiotic resistant infection. K. pneumoniae colonises the nasophary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d10a718a07518732d50c71bbe1a0d71
https://doi.org/10.1101/2022.10.03.510744
https://doi.org/10.1101/2022.10.03.510744
Autor:
Mohammad K. Manik, Yun Shi, Sulin Li, Mark A. Zaydman, Neha Damaraju, Samuel Eastman, Thomas G. Smith, Weixi Gu, Veronika Masic, Tamim Mosaiab, James S. Weagley, Steven J. Hancock, Eduardo Vasquez, Lauren Hartley-Tassell, Nestoras Kargios, Natsumi Maruta, Bryan Y. J. Lim, Hayden Burdett, Michael J. Landsberg, Mark A. Schembri, Ivan Prokes, Lijiang Song, Murray Grant, Aaron DiAntonio, Jeffrey D. Nanson, Ming Guo, Jeffrey Milbrandt, Thomas Ve, Bostjan Kobe
Publikováno v:
Science (New York, N.Y.). 377(6614)
Cyclic adenosine diphosphate (ADP)–ribose (cADPR) isomers are signaling molecules produced by bacterial and plant Toll/interleukin-1 receptor (TIR) domains via nicotinamide adenine dinucleotide (oxidized form) (NAD + ) hydrolysis. We show that v-cA
Autor:
Mohammad K. Manik, Yun Shi, Sulin Li, Mark A. Zaydman, Neha Damaraju, Samuel Eastman, Thomas G. Smith, Weixi Gu, Veronika Masic, Tamim Mosaiab, James S. Weagley, Steven J. Hancock, Eduardo Vasquez, Lauren Hartley-Tassell, Natsumi Maruta, Bryan Y. J. Lim, Hayden Burdett, Michael J. Lansdberg, Mark A. Schembri, Ivan Prokes, Lijiang Song, Murray Grant, Aaron DiAntonio, Jeffrey D. Nanson, Ming Guo, Jeffrey Milbrandt, Thomas Ve, Bostjan Kobe
Cyclic ADP ribose (cADPR) isomers are important signaling molecules produced by bacterial and plant Toll/interleukin-1 receptor (TIR) domains via NAD+ hydrolysis, yet their chemical structures are unknown. We show that v-cADPR (2’cADPR) and v2-cADP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb91a6ed2fc24e49f5ddcc0ff8b6a0f7
https://doi.org/10.1101/2022.05.07.491051
https://doi.org/10.1101/2022.05.07.491051