Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Steven J. Gould"'
Autor:
Dong-Chan Oh, Andrew W. Schultz, William Fenical, John R. Carney, R. Thomas Williamson, Steven J Gould, Bradley S. Moore, Paul R. Jensen, Daniel W. Udwary
Publikováno v:
Journal of the American Chemical Society. 130:4507-4516
Two new diketopiperazine dipeptides, cyclomarazines A and B, were isolated and characterized along with the new cyclic heptapeptide cyclomarin D from the marine bacterium Salinispora arenicola CNS-205. These structurally related cyclic peptides each
Publikováno v:
Tetrahedron Letters. 41:5181-5185
The biosynthesis of 3-amino-4-hydroxybenzoic acid (3,4-AHBA), a precursor to several Streptomyces secondary metabolites, requires the condensation of a three-carbon compound with a four-carbon unit derived from the tricarboxylic acid cycle. Using the
Publikováno v:
Tetrahedron. 56:693-701
The final steps in the biosynthesis of the antifungal peptidyl-nucleoside blasticidin S ( 3 ) have been revised to include a novel self-resistance mechanism wherein the previously proposed final precursor, demethylblasticidin S ( 7 ), is modified wit
Publikováno v:
Journal of Bacteriology. 181:2166-2174
Ten genes ( plt ) required for the biosynthesis of pyoluteorin, an antifungal compound composed of a bichlorinated pyrrole linked to a resorcinol moiety, were identified within a 24-kb genomic region of Pseudomonas fluorescens Pf-5. The deduced amino
Publikováno v:
Journal of Natural Products. 61:648-651
The identification of new cytosine glycosides and intermediates in the biosynthetic pathway of the antifungal antibiotic blasticidin S (1) was investigated using in vivo enzyme inhibition. Fermentations of Streptomyces griseochromogenes, the organism
Publikováno v:
The Journal of Antibiotics. 51:570-578
Two small chromosomal DNA fragments (2.6 and 4.8 kb) from the blasticidin S producer Streptomyces griseochromogenes were cloned in the high copy number vector pIJ702 and shown to confer increased resistance to blasticidin S upon S. lividans TK24. The
Publikováno v:
The Journal of Antibiotics. 51:50-57
The genes for most of the biosynthesis of the kinamycin antibiotics have been cloned and heterologously expressed. Genomic DNA of Streptomyces murayamaensis was partially digested with MboI and a library of approximately 40 kb fragments in E. coli XL
Publikováno v:
Gene. 204:17-24
Pyoluteorin is a chlorinated antifungal metabolite of mixed polyketide/amino-acid origin produced by certain strains of Pseudomonas spp., including the soil bacterium Pseudomonas fluorescens Pf-5. Sequence analysis of a gene cluster required for pyol
Publikováno v:
Tetrahedron Letters. 38:3139-3142
Streptomyces lividans ZX7 transformed with a ∼40 KB fragment of S. murayamaensis DNA produces the kinamycin biosynthetic intermediates kinobscurinone (1) and stealthin C (2a), as well as seongomycin (3), which had been previously observed in S. mur
Autor:
Chris R. Melville, Steven J. Gould
Publikováno v:
Tetrahedron Letters. 38:1473-1476
Kinobscurinone, a benzo[b]fluorenone quinone previously reported to be “NMR silent”, affording neither 1H- nor 13C NMR spectra under a variety of conditions, has now been shown to exist in part as a free radical under ambient conditions. The g va