Výsledky vyhledávání - "Steven J. Feinmark"

TASK-1 current is inhibited by phosphorylation during human and canine chronic atrial fibrillation

Autor: Steven J. Feinmark, Tove S. Rosen, Erin Harleton, Peter Danilo, Richard B. Robinson, Michael Argenziano, Michael R. Rosen, Alessandra Besana, Parag Chandra

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 308:H126-H134

Atrial fibrillation (AF) is a common arrhythmia with significant morbidities and only partially adequate therapeutic options. AF is associated with atrial remodeling processes, including changes in the expression and function of ion channels and sign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ae17ca4b270472400564798a009df09
https://doi.org/10.1152/ajpheart.00614.2014

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Increased late sodium current contributes to the electrophysiological effects of chronic, but not acute, dofetilide administration

Autor: Tobias Opthof, Xiaoliang Qiu, Tove S. Rosen, Steven J. Feinmark, Ira S. Cohen, Evgeny P. Anyukhovsky, Richard Z. Lin, Erin Harleton, Tania Rahim, Samuel Chauveau, Ruben Coronel, Michael R. Rosen, Michiel J. Janse, Ya Ping Jiang

Publikováno v: Circulation. Arrhythmia and Electrophysiology, 9(4). Lippincott Williams and Wilkins
Circulation. Arrhythmia and electrophysiology, 9(4). Lippincott Williams and Wilkins

Background— Drugs are screened for delayed rectifier potassium current ( I Kr ) blockade to predict long QT syndrome prolongation and arrhythmogenesis. However, single-cell studies have shown that chronic (hours) exposure to some I Kr blockers (eg,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47fa30e21f01bca54a955cf6e76544e5
https://dspace.library.uu.nl/handle/1874/345845

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Phorbol 12-Myristate 13-Acetate-dependent Protein Kinase Cδ-Tyr311 Phosphorylation in Cardiomyocyte Caveolae

Autor: Vitalyi O. Rybin, Zoya Gertsberg, Jianfen Guo, Susan F. Steinberg, Steven J. Feinmark

Publikováno v: Journal of Biological Chemistry. 283:17777-17788

Protein kinase Cdelta (PKCdelta) activation is generally attributed to lipid cofactor-dependent allosteric activation mechanisms at membranes. However, recent studies indicate that PKCdelta also is dynamically regulated through tyrosine phosphorylati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a4509a60d6e8b7850efd7d26d8abc47
https://doi.org/10.1074/jbc.m800333200

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TREK-1 Is a Novel Molecular Target in Prostate Cancer

Autor: I. Bernard Weinstein, Iryna Voloshyna, Mireia Castillo, Richard B. Robinson, Alessandra Besana, Steven J. Feinmark, Tulio Matos, Carlos Cordon-Cardo, Mahesh Mansukhani

Publikováno v: Cancer Research. 68:1197-1203

TREK-1 is a two-pore domain (K2P) potassium channel that carries a leak current that is time- and voltage-independent. Recently, potassium channels have been related to cell proliferation and some K2P family channels, such as TASK-3, have been shown

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cac08caaf8817ec10d2aa4674ae1674d
https://doi.org/10.1158/0008-5472.can-07-5163

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Platelet particle formation by anti–GPIIIa49-66 Ab, Ca2+ ionophore A23187, and phorbol myristate acetate is induced by reactive oxygen species and inhibited by dexamethasone blockade of platelet phospholipase A2, 12-lipoxygenase, and NADPH oxidase

Autor: Simon Karpatkin, Yelena Gor, Michael A. Nardi, Fang Xu, Steven J. Feinmark

Publikováno v: Blood. 110:1989-1996

An HIV antibody (Ab) against platelet integrin GPIIIa49-66 induces complement-independent platelet particle formation by the elaboration of reactive oxygen species (ROS) downstream of the activation of the platelet NADPH oxidase by the 12-lipoxygenas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc7b96ebd8647b6b91f01181302af878
https://doi.org/10.1182/blood-2006-10-054064

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Lipids and two-pore domain K+ channels in excitable cells

Autor: Steven J. Feinmark, Alessandra Besana, Richard B. Robinson

Publikováno v: Prostaglandins & Other Lipid Mediators. 77:103-110

Two-pore domain potassium channels (2PK) make up the newest branch of the potassium channel super-family. The channels are time- and voltage-independent and carry leak or “background” currents that are regulated by many different signaling molecu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c468c897a29ee977a2f5c6767a80a10
https://doi.org/10.1016/j.prostaglandins.2004.10.005

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Complement-independent Ab-induced peroxide lysis of platelets requires 12-lipoxygenase and a platelet NADPH oxidase pathway

Autor: Steven J. Feinmark, Michael A. Nardi, Simon Karpatkin, Zongdong Li, Liang Hu

Publikováno v: Journal of Clinical Investigation. 113:973-980

Antiplatelet GPIIIa49–66 Ab of HIV-related thrombocytopenic patients induces thrombocytopenia and platelet fragmentation by the generation of peroxide and other reactive oxygen species (ROS). Here we report the presence of a functional platelet NAD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe44ee445ad52d3cd9204d77c252299
https://doi.org/10.1172/jci20726

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Role of L-Type Calcium Channels in Pacing-Induced Short-Term and Long-Term Cardiac Memory in Canine Heart

Autor: Michael R. Rosen, Peter Danilo, Alexei N. Plotnikov, J. Christoph Geller, Ravil Z. Gainullin, Ira S. Cohen, Parag Chandra, Kornelis W. Patberg, Steven J. Feinmark, Steven Friezema, Han-Gang Yu

Publikováno v: Circulation. 107:2844-2849

Background— We tested the hypothesis that I Ca,L is important to the development of cardiac memory. Methods and Results— The effects of L-type Ca 2+ channel blockade and β-blockade were tested on acutely anesthetized and on chronically instrumen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee80fafaa96e9f6631a0b03831382021
https://doi.org/10.1161/01.cir.0000068376.88600.41

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Interactions between antiarrhythmic drugs and cardiac memory

Autor: W. Xiong, Michael R. Rosen, L. Rosenshtraukh, Alexei N. Plotnikov, Peter Danilo, J.R. (Joris) de Groot, Steven J. Feinmark, Alexei Shvilkin, Ravil Z. Gainullin

Publikováno v: Cardiovascular research, 50(2), 335-344. Oxford University Press

Objective: Ventricular pacing or arrhythmias can induce cardiac memory (CM). We hypothesized that clinically administered antiarrhythmic drugs alter the expression of CM, and that the repolarization changes characteristic of CM can modulate the effec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4a40a4d5df313db8adad1c0c00c71ab
https://doi.org/10.1016/s0008-6363(01)00233-4

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Alteration of human leukotriene A4 hydrolase activity after site-directed mutagenesis: serine-415 is a regulatory residue

Autor: Irina V. Rybina, Steven J. Feinmark

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1438:199-203

Leukotriene A4 hydrolase (LTA-H) is a bifunctional protein that has aminopeptidase activity, but also contains an epoxide hydrolase activity that converts leukotriene (LT)A4 to LTB4. The lipid metabolic activity of this enzyme plays a central role in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::951878f34227b92768dd4b3e68244ff6
https://doi.org/10.1016/s1388-1981(99)00046-3

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