Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Steven J. Darnell"'
Autor:
Michelle M Schiro, Sara E Stauber, Tami L Peterson, Chateen Krueger, Steven J Darnell, Kenneth A Satyshur, Norman R Drinkwater, Michael A Newton, F Michael Hoffmann
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e25021 (2011)
Hub proteins are connected through binding interactions to many other proteins. Smad3, a mediator of signal transduction induced by transforming growth factor beta (TGF-β), serves as a hub protein for over 50 protein-protein interactions. Different
Externí odkaz:
https://doaj.org/article/b017b6a5fd0045dd99b713cb37f62e65
Publikováno v:
Nucleic Acids Research
The KFC Server is a web-based implementation of the KFC (Knowledge-based FADE and Contacts) model—a machine learning approach for the prediction of binding hot spots, or the subset of residues that account for most of a protein interface's; binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a61805f3da2346a8e023bc5c3b73ca90
https://doi.org/10.1093/nar/gkn346
https://doi.org/10.1093/nar/gkn346
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 68:813-823
Protein–protein interactions can be altered by mutating one or more “hot spots,” the subset of residues that account for most of the interface's binding free energy. The identification of hot spots requires a significant experimental effort, hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea8704abb974b27c6c54a0a86eb973e8
https://doi.org/10.1002/prot.21474
https://doi.org/10.1002/prot.21474
Publikováno v:
Biophysical Journal. 106(2)
Monoclonal antibodies specific to unique antigens are invaluable biotechnological tools for diagnosing and treating human diseases. Their laborious production process creates a clear pharmaceutical and research need for tools that guide experiments t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a9a96bcf8d90652ea778d7775d85f1e
Autor:
F. Michael Hoffmann, Chateen Krueger, Sara E. Stauber, Michael A. Newton, Steven J. Darnell, Kenneth A. Satyshur, Norman R. Drinkwater, Tami L. Peterson, Michelle M. Schiro
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e25021 (2011)
PLoS ONE
PLoS ONE
Background Hub proteins are connected through binding interactions to many other proteins. Smad3, a mediator of signal transduction induced by transforming growth factor beta (TGF-β), serves as a hub protein for over 50 protein-protein interactions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e4c4205b2e28463eb82eb298ef650c6
http://europepmc.org/articles/PMC3176292?pdf=render
http://europepmc.org/articles/PMC3176292?pdf=render
Autor:
Steven J. Darnell, Julie C. Mitchell, Rajendra Kedlaya, Vijayasaradhi Setaluri, Kumar M.R. Bhat
PDZ proteins coordinate assembly of protein complexes that participate in diverse biological processes. GIPC is a multifunctional PDZ protein that interacts with several soluble and membrane proteins. Unlike most PDZ proteins, GIPC contains single PD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed241f8c82e9ef8ed317e5821e7eb22
https://europepmc.org/articles/PMC2877380/
https://europepmc.org/articles/PMC2877380/
