Detection of VEGF-A(xxx)b isoforms in human tissues.

Autor: David O Bates, Athina Mavrou, Yan Qiu, James G Carter, Maryam Hamdollah-Zadeh, Shaney Barratt, Melissa V Gammons, Ann B Millar, Andrew H J Salmon, Sebastian Oltean, Steven J Harper

Publikováno v: PLoS ONE, Vol 8, Iss 7, p e68399 (2013)

Vascular Endothelial Growth Factor-A (VEGF-A) can be generated as multiple isoforms by alternative splicing. Two families of isoforms have been described in humans, pro-angiogenic isoforms typified by VEGF-A165a, and anti-angiogenic isoforms typified

Externí odkaz: https://doaj.org/article/c5e11b23554f49f3992873cd602d0d0f

Reduced Glomerular Filtration in Diabetes Is Attributable to Loss of Density and Increased Resistance of Glomerular Endothelial Cell Fenestrations

Autor: Natalie C. Finch, Sarah S. Fawaz, Chris R. Neal, Matthew J. Butler, Vivian K. Lee, Andrew J. Salmon, Abigail C. Lay, Megan Stevens, Lusyan Dayalan, Hamid Band, Harry H. Mellor, Steven J. Harper, David T. Shima, Gavin I. Welsh, Rebecca R. Foster, Simon C. Satchell

Publikováno v: University of Bristol-PURE
J Am Soc Nephrol
Finch, N C, Fawaz, S, Neal, C R, Butler, M J, Salmon, A, Lay, A C, Stevens, M, Mellor, H H, Harper, S J, Welsh, G I, Foster, R & Satchell, S C 2022, ' Reduced glomerular filtration in diabetes is attributable to loss of density and increased resistance of glomerular endothelial cell fenestrations ', Journal of the American Society of Nephrology, vol. 33, no. 6, pp. 1120-1136 . https://doi.org/10.1681/ASN.2021030294

Background: Glomerular endothelial cell (GEnC) fenestrations are recognised as an essential component of the glomerular filtration barrier, yet little is known about how they are regulated and their role in disease.Methods: We comprehensively charact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8640d1b05cba480fd85861f51a3d378
https://doi.org/10.1681/asn.2021030294

Supplementary Table 1 from Association between VEGF Splice Isoforms and Progression-Free Survival in Metastatic Colorectal Cancer Patients Treated with Bevacizumab

Autor: Steven J. Harper, Al Bowen Benson, Neal J. Meropol, Bruce J. Giantonio, Peter J. O'Dwyer, Pramila Ramani, Alex H.R. Varey, Kirsty E. Symonds, Paul J. Catalano, David O. Bates

PDF file - 37K, Comparison of study cases and overall patient population

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::613a93b2cfc2385e5d153b0e59aad620
https://doi.org/10.1158/1078-0432.22446920

Cyclic Phosphopantothenic Acid Prodrugs for Treatment of Pantothenate Kinase-Associated Neurodegeneration

Autor: Daniel Elbaum, Daniel O. Cicero, Paola Fezzardi, Annalise Di Marco, Steven J. Harper, Savina Malancona, Elena Bracacel, Andrea Vecchi, Ilaria Rossetti, Edith Monteagudo, Alina Ciammaichella, Giulio Auciello, Odalys Gonzalez Paz, Maria G. Beconi

Publikováno v: Journal of Medicinal Chemistry. 63:15785-15801

Mutations in the human PANK2 gene are implicated in neurodegenerative diseases such as pantothenate kinase-associated neurodegeneration (PKAN) and result in low levels of coenzyme-A (CoA) in the CNS due to impaired production of phosphopantothenic ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c53c5a490a956c7c2db428b0dc609e43
https://doi.org/10.1021/acs.jmedchem.0c01531

5,6-Dihydroxypyrimidine Scaffold to Target HIV-1 Nucleocapsid Protein

Autor: Maria Rosaria Battista, Rajhans Sharma, Yves Mély, Marisabella Santoriello, Edith Monteagudo, Paola Fezzardi, Eleonore Real, Maurizio Zazzi, Vincenzo Summa, Mattia Mori, Maria Chiara Dasso Lang, Steven J. Harper, Savina Malancona, Antonella Cellucci, Manuel Pires, Martina Nibbio, Maurizio Botta, Roberto Speziale, Andreina Basta, Nadia Gennari, Francesco Saladini, Davide De Forni, Annalise Di Marco, Alessia Giannini, Lesia Kovalenko

Publikováno v: ACS Med Chem Lett

[Image: see text] The HIV-1 nucleocapsid (NC) protein is a small basic DNA and RNA binding protein that is absolutely necessary for viral replication and thus represents a target of great interest to develop new anti-HIV agents. Moreover, the highly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bca7f5ccee8b2fa882bee58c45c157f
https://doi.org/10.1021/acsmedchemlett.9b00608