Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Steven J Fliesler"'
Autor:
David M Sherry, Yogita Kanan, Robert Hamilton, Adam Hoffhines, Kelsey L Arbogast, Steven J Fliesler, Muna I Naash, Kevin L Moore, Muayyad R Al-Ubaidi
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39702 (2012)
To investigate the role(s) of protein-tyrosine sulfation in the retina and to determine the differential role(s) of tyrosylprotein sulfotransferases (TPST) 1 and 2 in vision, retinal function and structure were examined in mice lacking TPST-1 or TPST
Externí odkaz:
https://doaj.org/article/90340cc836e9408d8752f1973d5e283e
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5290 (2009)
Previously we have shown that compacted DNA nanoparticles can drive high levels of transgene expression after subretinal injection in the mouse eye. Here we delivered compacted DNA nanoparticles containing a therapeutic gene to the retinas of a mouse
Externí odkaz:
https://doaj.org/article/ca011eb9110643069edecc239df41407
Autor:
Steven J Fliesler
Publikováno v:
Journal of Ophthalmic & Vision Research, Vol 8, Iss 1, Pp 72-73 (2013)
Externí odkaz:
https://doaj.org/article/2e547218661c47ebb811d19a6d343e0c
Autor:
Houjian Zhang, Yuli Guo, Yaqiong Yang, Yuqian Wang, Youwen Zhang, Jingbin Zhuang, Yuting Zhang, Mei Shen, Jiankai Zhao, Rongrong Zhang, Yan Qiu, Shiying Li, Jiaoyue Hu, Wei Li, Jianfeng Wu, Haiwei Xu, Steven J. Fliesler, Yi Liao, Zuguo Liu
Publikováno v:
npj Regenerative Medicine, Vol 8, Iss 1, Pp 1-17 (2023)
Abstract Mammalian Müller glia (MG) possess limited regenerative capacities. However, the intrinsic capacity of mammalian MG to transdifferentiate to generate mature neurons without transgenic manipulations remains speculative. Here we show that MAP
Externí odkaz:
https://doaj.org/article/16a9a42bb2c64dc6838ca2613fdffc50
Autor:
Mai N. Nguyen, Dibyendu Chakraborty, Sriganesh Ramachandra Rao, Agnieszka Onysk, Mariusz Radkiewicz, Liliana Surmacz, Ewa Swiezewska, Eric Soubeyrand, Tariq A. Akhtar, Timothy W. Kraft, David M. Sherry, Steven J. Fliesler, Steven J. Pittler
Publikováno v:
Cell Death and Disease, Vol 14, Iss 7, Pp 1-10 (2023)
Abstract Retinitis pigmentosa (RP) defines a group of hereditary progressive rod-cone degenerations that exhibit a common phenotype caused by variants in over 70 genes. While most variants in the dehydrodolichyl diphosphate synthase (DHDDS) gene resu
Externí odkaz:
https://doaj.org/article/fee4e4b88da74e74bbf913af60ede5b9
Autor:
Steven J. Fliesler, Robert D. Steiner
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 8, Pp 100421- (2023)
Externí odkaz:
https://doaj.org/article/b193092c4de14f709bdee26330d31807
Publikováno v:
Biomolecules, Vol 14, Iss 3, p 341 (2024)
Sterol homeostasis in mammalian cells and tissues involves balancing three fundamental processes: de novo sterol biosynthesis; sterol import (e.g., from blood-borne lipoproteins); and sterol export. In complex tissues, composed of multiple different
Externí odkaz:
https://doaj.org/article/1c1651ead25c432d9821b5d4aa8a7e97
Autor:
Steven J. Pittler, Steven J. Fliesler
Publikováno v:
Cells, Vol 12, Iss 15, p 1933 (2023)
The recent success in the treatment of hereditary retinal disease caused by defects in the RPE65 gene and the FDA approval of this treatment has established the importance of the study of animal models and the translational impact of these research f
Externí odkaz:
https://doaj.org/article/933b0421850146ce9b6aef3b48722162
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 2, Pp 129-132 (2020)
Externí odkaz:
https://doaj.org/article/6f83d94b774047a6b5dc038b3957ed67
Autor:
Elliot H. Choi, Susie Suh, David E. Einstein, Henri Leinonen, Zhiqian Dong, Sriganesh Ramachandra Rao, Steven J. Fliesler, Seth Blackshaw, Minzhong Yu, Neal S. Peachey, Krzysztof Palczewski, Philip D. Kiser
Publikováno v:
JCI Insight, Vol 6, Iss 9 (2021)
The retinal pigment epithelium (RPE) provides vital metabolic support for retinal photoreceptor cells and is an important player in numerous retinal diseases. Gene manipulation in mice using the Cre-LoxP system is an invaluable tool for studying the
Externí odkaz:
https://doaj.org/article/9bd5b7f2aed546ab8d29ac38a52ecb52