Výsledky vyhledávání - "Steven J Culliford"

Synthesis, evaluation and incorporation into liposomes of 4-functionalised-2,5-diphenyloxazole derivatives for application in scintillation proximity assays

Autor: Andrew J. Sutherland, Mark C. McCairn, Steven J Culliford, Roland Z. Kozlowski

Publikováno v: Tetrahedron Letters. 45:2163-2166

The preparation of a series of 4-functionalised-2,5-diphenyloxazoles is described. The scintillating efficiency of each of these ‘scintilipid’ molecules has been evaluated in the presence of ionising radiation. Each ‘scintilipid’ has been ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63eda2fe80028053ddc775e261d0b0ee
https://doi.org/10.1016/j.tetlet.2004.01.034

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Newly identified structurally disparate modulators of osmosensitive taurine efflux inhibit cell cycle progression

Autor: Roland Z. Kozlowski, Harry J. Witchel, Steven J Culliford, Richard M. Morley, Mark J. Belsey

Publikováno v: European Journal of Pharmacology. 474:185-193

FACS analysis and [14C]-taurine efflux were used to determine whether activation of the volume-sensitive organic osmolyte/anion channel plays a role in cell cycle progression. This was achieved by examining the effects of a collection of (i) H(1) ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34ceaec1c2b2739bda25dd114b8eeb26
https://doi.org/10.1016/s0014-2999(03)02073-9

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A novel cell-based scintillation proximity assay for studying protein function and activity in vitro using membrane-soluble scintillants

Autor: John D. Sutherland, Roland Z. Kozlowski, Steven J Culliford, Andrew J. Sutherland, Jonathan M. Blackburn, Patrick McCauley, Mark C. McCairn

Publikováno v: Biochemical and Biophysical Research Communications. 296:857-863

Here we describe for the first time a cell-based scintillation proximity assay using membrane soluble scintillants (MSS). MSS have a scintillant `head' group (2,5-diphenyloxazole) attached to a lipophilic `tail.' MSS do not scintillate in an aqueous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdf0fc3ecb840211cf3fd1bbbe934c56
https://doi.org/10.1016/s0006-291x(02)00944-0

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Cardiac chloride channels: physiology, pharmacology and approaches for identifying novel modulators of activity

Autor: John Joseph Borg, Stephen G. Davies, Andrew W. Mulvaney, Steven J Culliford, C. Ian Spencer, Roland Z. Kozlowski

Publikováno v: Drug Discovery Today. 5:492-505

Drugs that block cardiac cation channels have been marketed as the therapeutic answer to cardiac arrhythmia. However, such molecules have been only moderately successful at improving the survival of cardiac patients, and so new targets have been need

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec81df4963e705b60739816e6c4480ea
https://doi.org/10.1016/s1359-6446(00)01561-0

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