Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Steven J Coote"'
The 1-exo proton of tricarbonyl-4-exo-methyl- or tricarbonyl-4-exo-ethyl-2-methyl-1,2,3,4-tetrahydroisoquinolinechromium (6) and (7) can be regio- and stereo-selectively removed by t-butyl-lithium and replaced with a variety of electrophiles to give
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83448fb5a6fcf62c322af3eee32738f1
https://doi.org/10.1039/p19870000689
https://doi.org/10.1039/p19870000689
Autor:
Mark Whittaker, R. P. Beckett, Isabelle M. Dordor-Hedgecock, Steven J. Coote, John P. McNally, Craig L. Goodfellow, George Bashiardes, G. L. Gravatt, Stephen G. Davies
Stoichiometric reagents for the control of the absolute stereochemistry of new chiral centres produced during reactions involving carbon-carbon bond formation are described. Chiral iron acyl reagents act as chiral equivalents of a variety of carbonyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6eac7883dbdb243df6951c012b7240a
https://doi.org/10.1098/rsta.1988.0113
https://doi.org/10.1098/rsta.1988.0113
Acid-promoted cyclisation of (+)-(R)-N-(3,4-dimethoxybenzyl)halostachine tricarbonylchromium at –20 °C is highly stereoselective, proceeding with retention of configuration, to yield, after removal of the tricarbonylchromium unit, homochiral (+)-(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fdb07bf2d97bd4712eb2c4f0a0816e5
https://ora.ox.ac.uk/objects/uuid:87177752-f0a1-477f-8f67-6252ddd637ab
https://ora.ox.ac.uk/objects/uuid:87177752-f0a1-477f-8f67-6252ddd637ab
Autor:
Craig L. Goodfellow, Stephen G. Davies, Alan Naylor, Steven J. Coote, David Middlemiss, K. H. Sutton
(−)-(1 S ,2 S )-( N ,O-Dimethylephedrine)tricarbonyl chromium(0) (6) and (−)-(1 S ,2 R )-( N ,O-dimethylpseudoephedrine)tricarbonylchiromium(0) ( 22 ) undergo completely stereoselective ortho deprotonation upon treatment with alkyllithium base, f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3b2cf9c887daebd20ccb4efc7af5e4b
https://doi.org/10.1016/s0957-4166(00)80447-4
https://doi.org/10.1016/s0957-4166(00)80447-4
Autor:
Joann M. Um, Steven J. Coote, Nigel J. Reynolds, Christopher D. Bray, David M. Hodgson, Nicholas D. Kindon, K. N. Houk
Publikováno v:
The Journal of Organic Chemistry. 74:1019-1028
A new reactivity mode of hindered lithium amides with terminal epoxides is described whereby aldehyde enamines are produced via a previously unrecognized reaction pathway. Some of these aldehyde enamines display unprecedented C-alkylation reactivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4905d25a1c415a8220341db4e0993b34
https://doi.org/10.1021/jo802016t
https://doi.org/10.1021/jo802016t
Synthesis of trans-fused [5,5] bicyclic lactones/lactams as templates for serine protease inhibition
Autor:
Doreen Golding, Martin R. Owen, Mike Dowle, B.C. Ross, Jessica McLaren, Neil Anthony Pegg, Ulrich Conrad Dyer, J.G. Montana, Harry Finch, Andrew Lowdon, Steven J Coote, Henry A. Kelly, Richard Bolton, Stuart A. Brown, Rhian Thomas, Dawn Walker
Publikováno v:
Tetrahedron Letters. 39:6979-6982
Efficient routes have been developed for the synthesis of the trans-lactone2, the trans-lactam3 and their 3-substituted analogues based upon cyclisation strategies using Mukaiyama's reagent. 3β-Allyl, thiophenyl and propyl lactones 5 inhibit chymotr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7729d0be1f43ba91fcf9f0198da67e67
https://doi.org/10.1016/s0040-4039(98)01481-6
https://doi.org/10.1016/s0040-4039(98)01481-6
Publikováno v:
Tetrahedron: Asymmetry. 6:2535-2546
The palladium catalysed reaction between non-symmetrical allyl acetates and sodiodimethylmalonate proceeds in high yields and enantioselectivities (up to 99% ee) using a diphenylphosphinoaryl oxazoline ligand. The so-formed substitution products are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfd62dfcbec755931dd40331a396bfa6
https://doi.org/10.1016/0957-4166(95)00332-j
https://doi.org/10.1016/0957-4166(95)00332-j
Publikováno v:
Tetrahedron Letters. 43:7895-7897
Lithiation-in situ silylation of simple terminal epoxides using lithium 2,2,6,6-tetramethylpiperidide in combination with trimethylsilyl chloride provides a direct and experimentally convenient process for the synthesis of trans-α,β-epoxysilanes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7211e0722d70d9088ba00226e5a73ac
https://doi.org/10.1016/s0040-4039(02)01893-2
https://doi.org/10.1016/s0040-4039(02)01893-2
Autor:
Kenneth Lyle Clark, Steven J Coote, K.S. Cardwell, J.G. Montana, Steve P. Watson, G.C. Hirst, G.R.M. Manchee, J. Hamblett, M.J. Robertson, David Middlemiss, M. Donnelly, B.C. Ross, T.A. Panchal, E. Palmer, J.M.S. Paton, A. Hilditch, G.M. Drew, David I. C. Scopes, M. Pass, M.D. Dowle, J. Bradshaw, Torquil I. Jack, T. Hubbard, M.K. Bayliss, G. Stuart, P. Shah
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:589-594
A study of structure activity relationships based on the bromobenzofuran angiotensin II antagonist GR117289 is reported. This study led to the identification of compounds with potency in vitro enhanced by ca. 10 fold. Also reported is the enhancement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbaea88e6d2f5f5513c4ccd3cdac2b65
https://doi.org/10.1016/s0960-894x(01)81235-x
https://doi.org/10.1016/s0960-894x(01)81235-x
Autor:
Stephen G. Davies, Steven J. Coote, David Middlemiss, Craig L. Goodfellow, K. H. Sutton, Alan Naylor
Publikováno v:
ChemInform. 22
(−)-(1 S ,2 S )-( N ,O-Dimethylephedrine)tricarbonyl chromium(0) (6) and (−)-(1 S ,2 R )-( N ,O-dimethylpseudoephedrine)tricarbonylchiromium(0) ( 22 ) undergo completely stereoselective ortho deprotonation upon treatment with alkyllithium base, f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dae51d8f5225f93a543163a027e44401
https://doi.org/10.1002/chin.199113226
https://doi.org/10.1002/chin.199113226