Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Steven J Chapin"'
Autor:
Edith A Perez, Andrew Luo, Anthony Lucas, Han K Kim, Paul D Ponath, Katelynn A McEachin, Karla A Henning, Shelley E Ackerman, Steven J Chapin, Michael N Alonso, Cecelia I Pearson, David Omstead
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/3dd5d80f575f46cfba2236317430d3dc
Autor:
Matthew Zhou, William Mallet, Romas Kudirka, Han K Kim, Justin Monnier, Chi-Ling Fu, Jennifer E Melrose, Hung Dao, Paul D Ponath, Katelynn A McEachin, David T Omstead, Cindy Kreder, Stefan Chun, Ying Yueh Lee, Rachel Grgich, Tracey J Lin, Joshua A Walker, Karla A Henning, Shelley E Ackerman, Diane Carrera, Steven J Chapin, Dowdy Jackson, Changshou Gao, Michael N Alonso
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 2 (2023)
Externí odkaz:
https://doaj.org/article/30e7900b97ae4dd8a324a8032d05c871
Autor:
Justin A. Kenkel, Fang Xiao, Po Y. Ho, Jess L. Nolin, Rishali K. Gadkari, Laughing Bear Torrez, David T. Omstead, Katelynn A. McEachin, Jason Ptacek, Rachel Grgich, Cecelia I. Pearson, Stefan Chun, Cindy L. Kreder, Karla A. Henning, Han K. Kim, Lu Xu, Steven J. Chapin, Michael N. Alonso, Shelley E. Ackerman
Publikováno v:
Cancer Research. 83:2964-2964
Tumor-associated macrophages (TAMs) are the largest immune cell population in many cancers and play a key role in establishing the immunosuppressive tumor microenvironment (TME) that enables tumor progression. However, TAMs are phenotypically plastic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5aeb383fd1922289f6d50589d9598bd
https://doi.org/10.1158/1538-7445.am2023-2964
https://doi.org/10.1158/1538-7445.am2023-2964
Autor:
Karla Henning, Yuyi Shen, Jennifer Melrose, David Dornan, AAngela Luondrew Luo, Rishali Gadkari, Michael N. Alonso, Laughing Bear Torrez Dulgeroff, Jess Nolin, Cecelia Pearson, Ganapathy Sarma, Brian Safina, Edith A. Perez, Shelley Erin Ackerman, Liz Bogaert, Arthur Lee, Romas Kudirka, William Mallet, Lisa Blum, Puneet Anand, Angela Luo, Amreen Husain, Steven J. Chapin, Marcin Kowanetz, Matthew Zhou
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundCEA (CEACAM5) is a well-validated cell-surface antigen that is highly expressed in multiple solid tumors. Bolt's immune-stimulating antibody conjugates (ISACs) direct a TLR7/8 agonist into tumors to activate tumor-infiltrating myeloid cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4083ed624d53c4e45a44ef917b504cf
https://doaj.org/article/fb2042523bb947d7be8150b8d9c85ab4
https://doaj.org/article/fb2042523bb947d7be8150b8d9c85ab4
Autor:
Lisa K. Blum, Cecelia I. Pearson, Laughing Bear Torrez Dulgeroff, Rishali Gadkari, Angela Luo, Andrew Luo, Jennifer E. Melrose, Jess L. Nolin, Hai Li, Arthur Lee, Matthew N. Zhou, Puneet Anand, Ganapathy Sarma, Karla A. Henning, Steven J. Chapin, Shelley E. Ackerman, Romas Kudirka, Yuyi Shen, Bruce Hug, Edith A. Perez, Marcin Kowanetz, Michael N. Alonso, Brian S. Safina, David Dornan, William G. Mallet
Publikováno v:
Cancer Research. 82:2911-2911
Introduction: Immune-stimulating antibody conjugates (ISACs) direct a TLR7/8 agonist into tumors through engagement of cell surface antigens to activate tumor-associated myeloid cells and initiate a broad innate and adaptive anti-tumor immune respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::050815ec20aebbbb637033acbc3a563a
https://doi.org/10.1158/1538-7445.am2022-2911
https://doi.org/10.1158/1538-7445.am2022-2911
Autor:
Justin A. Kenkel, Rishali Gadkari, Po Y. Ho, Lisa K. Blum, Romas Kudirka, Karla A. Henning, William G. Mallet, Jennifer E. Melrose, Ganapathy Sarma, Steven J. Chapin, Matthew Zhou, Suprit Deol, Cindy Kreder, Yuyi Shen, Bruce Hug, Puneet Anand, Arthur Lee, Hai Li, Shelley E. Ackerman, Brian S. Safina, David Dornan, Michael N. Alonso, Marcin Kowanetz
Publikováno v:
Cancer Research. 82:4252-4252
INTRODUCTION: Immune-stimulating antibody conjugates (ISACs) consist of tumor-targeting antibodies conjugated to immune stimulants and are designed to activate the innate and adaptive immune systems against tumor cells following systemic administrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1dbf4f693cc6d47982df7afbd2d099b5
https://doi.org/10.1158/1538-7445.am2022-4252
https://doi.org/10.1158/1538-7445.am2022-4252
Autor:
Justin A. Kenkel, Po Y. Ho, Karla A. Henning, Cindy L. Kreder, Jess L. Nolin, Sameera Kongara, Steven J. Chapin, Amreen Husain, Marcin Kowanetz, Edgar G. Engleman, Michael N. Alonso, David Dornan, Shelley E. Ackerman
Publikováno v:
Cancer Research. 82:2883-2883
Tumor-associated macrophages (TAMs), an abundant immune cell population in most cancers, support tumor progression through their immunosuppressive effects. We discovered that TAMs express the pattern recognition receptor Dectin-2 (Clec4n/CLEC6A), an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6f397056d127fdaa4a49a36634f5b3f
https://doi.org/10.1158/1538-7445.am2022-2883
https://doi.org/10.1158/1538-7445.am2022-2883
Autor:
Hai Li, Andrew Luo, Steven J. Chapin, Shelley Erin Ackerman, Marcin Kowanetz, Michael N. Alonso, Po Y. Ho, Arthur Lee, Karla Henning, Samuel C. Kimmey, Benjamin Ackerman, Joshua D. Gregorio, Brian Safina, Vishnu C. Ramani, David Dornan, Lauren Y. Sheu, Jennifer Melrose, Cecelia Pearson, Richard P. Laura, Bruce H. Devens, Justin A. Kenkel, Edgar G. Engleman, Lisa Blum, David Y. Jackson, Heidi N. Leblanc, Joseph C. Gonzalez, Grant Yonehiro, Yaron Carmi, Felix J. Hartmann, Sean C. Bendall, Murray L. Nguyen, Angela Luo, Jason C. Paik
Publikováno v:
Nat Cancer
Innate pattern recognition receptor agonists, including Toll-like receptors (TLRs), alter the tumor microenvironment and prime adaptive antitumor immunity. However, TLR agonists present toxicities associated with widespread immune activation after sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::436acc59b100dcb9f23295f5a324b4fb
https://europepmc.org/articles/PMC9012298/
https://europepmc.org/articles/PMC9012298/
Autor:
Andrew Luo, Joseph C. Gonzalez, Richard P. Laura, Michael N. Alonso, Samuel C. Kimmey, David Y. Jackson, Shelley Erin Ackerman, David Dornan, Benjamin Ackerman, Edgar G. Engleman, Po Yi Ho, Felix J. Hartmann, Bruce H. Devens, Jason C. Paik, Sean C. Bendall, Arthur Lee, Steven J. Chapin, Cecelia Pearson, Karla Henning
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Immune stimulating antibody conjugates (ISACs) covalently attach TLR7/8 immune stimulants to tumor-targeting antibodies. ISACs can be delivered systemically and act locally in the tumor microenvironment by requiring the following biologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18731c6e9988ac6872dda1adb861d3c2
https://doaj.org/article/f5d7558c062d476da010b826729b37c4
https://doaj.org/article/f5d7558c062d476da010b826729b37c4
Autor:
Rishali Gadkari, Puneet Anand, Shelley Erin Ackerman, Jennifer Melrose, Romas Kudirka, Karla Henning, Ganapathy Sarma, Steven J. Chapin, Matthew Zhou, Arthur Lee, Suprit Deol, Cindy Kreder, Justin A. Kenkel, David Dornan, Marcin Kowanetz, William Mallet, Michael N. Alonso, Brian Safina, Liz Bogaert, Po Ho, Hai Li, Yuyi Shen
Publikováno v:
Journal for ImmunoTherapy of Cancer. 9:A817-A817
BackgroundPD-L1 is an immune checkpoint that regulates anti-tumor T cell responses and is expressed on tumor cells as well as tumor-infiltrating immune cells across many tumor types. Immune-stimulating antibody conjugates (ISACs) consist of tumor-tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05bd860258c49f32d9032ebdfbb9671d
https://doi.org/10.1136/jitc-2021-sitc2021.782
https://doi.org/10.1136/jitc-2021-sitc2021.782