Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation

Autor: Lars Plate, Christina B Cooley, John J Chen, Ryan J Paxman, Ciara M Gallagher, Franck Madoux, Joseph C Genereux, Wesley Dobbs, Dan Garza, Timothy P Spicer, Louis Scampavia, Steven J Brown, Hugh Rosen, Evan T Powers, Peter Walter, Peter Hodder, R Luke Wiseman, Jeffery W Kelly

Publikováno v: eLife, Vol 5 (2016)

Imbalances in endoplasmic reticulum (ER) proteostasis are associated with etiologically-diverse degenerative diseases linked to excessive extracellular protein misfolding and aggregation. Reprogramming of the ER proteostasis environment through genet

Externí odkaz: https://doaj.org/article/42f2f67790644b3da9a9b3bdc96ee5c4

The gait profile score characterises walking performance impairments in young stroke survivors

Autor: Claire Butterworth, Louisa Walker, Karl Jackson, Renee Groenevelt, Michelle A. Price, Abigail Clayton, Steven J. Brown, Neil D. Reeves, Hannah L. Jarvis, Nia Rees

Publikováno v: Gait & Posture. 91:229-234

Background: The Gait Profile Score (GPS) provides a composite measure of the quality of joint movement during walking, but the relationship between this measure and metabolic cost, temporal (e.g. walking speed) and spatial (e.g. stride length) parame

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1046c716b7dd229ec8f7378dc4754ae8
https://doi.org/10.1016/j.gaitpost.2021.10.037

Transgenerational impacts of herbivory and inbreeding on reproductive output in Solanum carolinense

Autor: Consuelo M. De Moraes, William S. Walker, Chad T. Nihranz, Andrew G. Stephenson, Steven J. Brown, Mark C. Mescher

Publikováno v: American Journal of Botany
American Journal of Botany, 107 (2)

Premise Plant maternal effects on offspring phenotypes are well documented. However, little is known about how herbivory on maternal plants affects offspring fitness. Furthermore, while inbreeding is known to reduce plant reproductive output, previou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b789884c160eddf04a36e78e359d20f
https://doi.org/10.1002/ajb2.1402

Maternal thiopurine metabolism during pregnancy in inflammatory bowel disease and clearance of thiopurine metabolites and outcomes in exposed neonates

Autor: Emma, Flanagan, Emily K, Wright, Winita, Hardikar, Miles P, Sparrow, William R, Connell, Michael A, Kamm, Peter, De Cruz, Steven J, Brown, Alexander, Thompson, Anthea, Greenway, Ian, Westley, Murray, Barclay, Alyson L, Ross, Katerina V, Kiburg, Sally J, Bell

Publikováno v: Alimentary pharmacologytherapeuticsREFERENCES. 53(7)

Azathioprine and mercaptopurine are considered safe during pregnancy. However, the pharmacokinetic effects of pregnancy on thiopurine metabolism are undefined.To characterise thiopurine metabolism in pregnancy and measure infant metabolite levels and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6284d98f6960f01cfbfc87124852d1d0
https://pubmed.ncbi.nlm.nih.gov/34109665

Anti-TNF Therapy in Pregnant Women With Inflammatory Bowel Disease:Effects of Therapeutic Strategies on Disease Behavior and Birth Outcomes

Autor: William Connell, Kavitha Subramaniam, Mille Baekdal, Peter R. Gibson, Peter A. Bampton, Gregory T. Moore, Nanna M. Jensen, Michael A. Kamm, Ian C. Lawrance, Jane M. Andrews, Trine Boysen, K. Ellard, Graham L. Radford-Smith, Miles P. Sparrow, Alissa Walsh, Lise Svenningsen, Mette Julsgaard, Signe Wildt, Jan Fallingborg, Lisbet Ambrosius Christensen, Susan J. Connor, Sally Bell, Thea Vestergaard, Steven J. Brown, Jens Kjeldsen, Christian Lodberg Hvas, Bo Martin Bibby, Richard B. Gearry, Heidi Kammerlander, Benedicte Vibjerg Wilson

Publikováno v: Julsgaard, M, Hvas, C L, Gearry, R B, Gibson, P R, Fallingborg, J, Sparrow, M P, Bibby, B M, Connell, W R, Brown, S J, Kamm, M A, Lawrance, I C, Vestergaard, T, Svenningsen, L, Baekdal, M, Kammerlander, H, Walsh, A, Boysen, T, Bampton, P, Radford-Smith, G, Kjeldsen, J, Andrews, J M, Subramaniam, K, Moore, G T, Jensen, N M, Connor, S J, Wildt, S, Wilson, B, Ellard, K, Christensen, L A & Bell, S J 2020, ' Anti-TNF Therapy in Pregnant Women With Inflammatory Bowel Disease : Effects of Therapeutic Strategies on Disease Behavior and Birth Outcomes ', Inflammatory Bowel Diseases, vol. 26, no. 1, pp. 93-102 . https://doi.org/10.1093/ibd/izz110
Julsgaard, M, Hvas, C L, Gearry, R B, Gibson, P R, Fallingborg, J, Sparrow, M P, Bibby, B M, Connell, W R, Brown, S J, Kamm, M A, Lawrance, I C, Vestergaard, T, Svenningsen, L, Baekdal, M, Kammerlander, H, Walsh, A, Boysen, T, Bampton, P, Radford-Smith, G, Kjeldsen, J, Andrews, J M, Subramaniam, K, Moore, G T, Jensen, N M, Connor, S J, Wildt, S, Wilson, B, Ellard, K, Christensen, L A & Bell, S J 2020, ' Anti-TNF therapy in pregnant women with inflammatory bowel disease : Effects of therapeutic strategies on disease behavior and birth outcomes ', Inflammatory Bowel Diseases, vol. 26, no. 1, pp. 93-102 . https://doi.org/10.1093/ibd/izz110

BACKGROUND: Active inflammatory bowel disease (IBD) adversely affects pregnancy outcomes. Little is known about the risk of relapse after stopping anti-tumor necrosis factor (anti-TNF) treatment during pregnancy. We assessed the risk of relapse befor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ffdf673f00119b1f26185c365a56072
https://portal.findresearcher.sdu.dk/da/publications/bd6a3c6a-e835-44df-b40e-1b569aea2b16